CXCR4hi #CARTcells boost #TumorTracking, #BoneMarrow homing, and persistence, enhancing #Antitumor activity; early trial data in B cell malignancies show multiple complete responses, supporting #CXCR4 modification.
#OpenAccess in #STTT: doi.org/10.1038/s413...
Scientists show that engineering #CARTcells to overexpress #CXCR4 restores #CXCL12-guided migration, enhances #tumortracking and #BoneMarrow homing, promotes memory persistence, and improves #antitumor efficacy in #BcellLymphoma and #myeloma.
#STTT: doi.org/10.1038/s413...
AI Maps Tumor Cells, Blood Filter Saves Child #Science #HealthandMedicine #Oncology #TumorTracking #MedicalInnovation #ChildHealth
