#Bcl6 inhibition destabilizes #TregCells by reducing H3K4me3, enhancing #AntiTumor immunity, delaying #HeadandNeckSquamousCellCarcinoma progression, and synergizing with immune checkpoint therapy, highlighting Bcl6 as a promising target.
#OpenAccess: doi.org/10.1016/j.ge...
Intestinal #TregCells promote epithelial repair by combining #IFNγ and #IL10 signaling to drive #organoid growth, preserve #IntestinalStemCells, and enable #gut regeneration.
@tum.de @univparissaclay.bsky.social
#OpenAccess in #STTT: doi.org/10.1038/s413...
Bcl6 controls the stability and suppressive function of regulatory T cells in head and neck squamous cell carcinoma
Specific abrogation of Bcl6 in #TregCells delays the malignant transformation in the 4NQO-induced HNSCC model by impairing the lineage stability of Treg cells via down-regulating #histone H3K4 #trimethylation. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
Researchers identified a substantial presence of peripherally induced Treg cells in TME - John Gordon
oncodaily.com/science/239794
#Cancer #JournalOfExperimentalMedicine #OncoDaily #Oncology #RegulatoryTCells #TregCells #Medicine #Health #TumorMicroenvironment
