Intestinal #TregCells promote epithelial repair by combining #IFNγ and #IL10 signaling to drive #organoid growth, preserve #IntestinalStemCells, and enable #gut regeneration.
@tum.de @univparissaclay.bsky.social

#OpenAccess in #STTT: doi.org/10.1038/s413...

🔥Hot Off the Press | #Cell: #Mucosal viral infection induces gut-resident #IgA+ #LLPCs
🔹#Antigen presentation on B cell induces virus-specific #TFH1 cells via #IFNγ- and #CXCR3-dependent mechanisms
👉TFH1 cells facilitate IgA responses to mucosal viral infections

Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii Author summary Coxiella burnetii is a mammalian pathogen that can cause a predominantly zoonotic disease called Q-fever. In humans, Q-fever manifests as an acute or chronic illness especially in immun...

journals.plos.org/plospathogen...

"Effector mechanisms induced by the pro-inflammatory cytokine Interferon-gamma ( #IFNγ) can promote the delivery of pathogen-occupied vacuoles to lysosomes for proteolytic degradation and are therefore important for host defense against intracellular pathogens."

Drs Png Loke & Oyebola Oyesola highlight Irah King & colleagues’ @cp-cell.bsky.social‬ article on type 1 #immune-#stromal cell network during #helminth infections. #IFNγ #Microbiota @niaidnews.bsky.social‬ ‪@rimuhc.bsky.social‬ @mcgill-microbiome.bsky.social‬

authors.elsevier.com/a/1lCE95Eb1x...

Further Therapies to Enhance #IFNγ Production and #MHC I Expression in #cancer besides IL-2 mRNA
#science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky
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