Our video section got a glow-up—plus, anatomy is here, with new videos dropping weekly🫀
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Just so the 🧵 is completed 😀
the paper is now available @bmj.com -Open & downloadable as PDF
🔗https://bmjopen.bmj.com/content/15/3/e095777
And, maybe some more to add to the 🧵 soon 😉
@lancasteruni.bsky.social @ljmuofficial.bsky.social et al 👇
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MHC Expression and the Effectivenes of mRNA Vaccines in Cancer Therapy
Part 2
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MHC Expression and the Effectivenes of mRNA Vaccines in Cancer Therapy
Part 1
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Tumor Mutational Burden and the Effectivenes of mRNA Vaccines in Cancer Therapy
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Tumor Mutation Rate and the Effectivenes of mRNA Vaccines in Cancer Therapy
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Tumor Microenvironment (TME) and the Effectivenes of mRNA Vaccines in Cancer Therapy
Part 2
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Tumor Microenvironment (TME) and the Effectivenes of mRNA Vaccines in Cancer Therapy
Part 1
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Synthetic Spore Husk-Encased Lipid bilayer (SSHELs) mimic bacterial spores and deliver peptides to dendritic cells, showing efficient tumor regression and improved survival in mice. SSHELs require complex synthesis but avoid cell culture use, unlike VLPs. #MedSky #MedEd #medschoolsky #immunosky
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Further Therapies to Enhance #IFNγ Production and #MHC I Expression in #cancer besides IL-2 mRNA
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Overcoming #MHC Downregulation in #Cancer Therapy by Modifying #mRNA #Vaccination
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#Immunescape mechanisms to alternative immune activation pathways in #MHC deficient #cancer
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Alternative immune activation pathways in #MHC deficient #cancer
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Consequences of #MHC downregulation in #cancer therapy
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Causes of #MHC downregulation in #cancer
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DNA damage activates ATM-dependent apoptosis in B cells. ATM and Bcl-2 defects promote lymphomas, inhibit apoptosis, and worsen prognosis. APO-1 mutations block TNFα-induced cell destruction.
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The liver produces proteins, stores vitamins, makes bile, regulates carbs, and detoxifies. Fatty liver disease, often from alcohol, can cause organ failure, cirrhosis, liver cancer, and esophageal varices.
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The production of personalized #mRNA #vaccines in #cancer therapy
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#histology: pancreas in HEstaining
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The detection of immunogenic neoantigens for personalized #mRNA #vaccines in #cancer therapy
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Comparison: Mass Spectrometry Imaging (MALDI MSI) vs Gene expression analysis
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Burkitt lymphoma: In the blood smear, vacuolated blasts with very basophilic plasma, as well as round, sometimes multiple cell nuclei alongside bright macrophages can be seen.
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Comparison: Mass Spectrometry Imaging (MALDI MSI) vs Immunohistochemistry
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Uses of Mass Spectrometry Imaging (MALDI MSI) Part 3
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Uses of Mass Spectrometry Imaging (MALDI MSI) Part 2
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Uses of Mass Spectrometry Imaging (MALDI MSI) Part 1
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Multiple enlarged plasma cells in bood smear indicating a multiple myeloma.
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Method of Mass Spectrometry Imaging (MALDI MSI) Part 2
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