From DNA Repair to Redox Signaling: The Multifaceted Role of APEX1 (Apurinic/Apyrimidinic Endonuclease 1) in Cardiovascular Health & Disease

Appreciate my PhD supervisor, Dr. Xi-Long Zheng, for inviting me to write this review😁

#IJMS_MDPI 2025
www.mdpi.com/1422-0067/26...

Endothelial-to-Mesenchymal Transition in Cardiovascular Pathophysiology
#EndMT

#Atherosclerosis
#VascularCalcification
#PeripheralArteryDisease
#PulmonaryHypertension
#ValvularHeartDisease
#MyocardialInfarction
#CardiacFibrosis

Krishna Singh lab #IJMS_MDPI 2024
www.mdpi.com/1422-0067/25...

Non-Hepatic #PCSK9 #Obesity

Higher PCSK9 in aortic #SmoothMuscleCell from Obese (vs Lean) Zucker rats
Depending on ERK1/2, PKC & NAPDH oxidase

Any secreted PCSK9 from SMCs? How SMC-derived PCSK9 impacts atherogenesis?

#IJMS_MDPI 2025
www.mdpi.com/1422-0067/26...

Immune System-Related Plasma Pathogenic Extracellular Vesicle Subpopulations Predict Osteoarthritis Progression Certain molecules found on the surface or within the cargo of extracellular vesicles (EVs) are linked to osteoarthritis (OA) severity and progression. We aimed to identify plasma pathogenic EV subpopu...

Congratulations to #DukeMGC Lead Bioinformatician VJ
for his authorship on 'Immune System-Related Plasma Pathogenic Extracellular Vesicle Subpopulations Predict #Osteoarthritis Progression' w/ Virginia Krauss' lab

mdpi.com/3051878 #mdpiijms via #IJMS_MDPI

#EndMT #Aortopathy #MarfanSyndrome

A cascade of TGFβ-miR-632-DNAJB6 (#LimbGirdleMuscularDystrophy 1E)-βCatenin in both #EndothelialCell & #SmoothMuscleCell

miR-632 mimics delivery (lipofectamine) to cultured human aortic fragments

#IJMS_MDPI 2023
www.mdpi.com/1422-0067/24...

Scoring histopathologies of human ascending aortic dissection (n=52, 32 mortality) vs aneurysm (n=56, 9 mortality)

#CysticMedialDegeneration
Elastin loss
#SmoothMuscleCell loss
Lamellar medial collapse (?)

#AortaEd
Simona Gurzu lab #IJMS_MDPI 2023
www.mdpi.com/1422-0067/24...

Is There Enough Evidence to Support the Role of Glycosaminoglycans and Proteoglycans in Thoracic Aortic Aneurysm & Dissection?—A Systematic Review

Nice ref resource, though our #JACCIMG paper not cited🥹👇
www.jacc.org/doi/full/10....

Jillian Madine lab #IJMS_MDPI 2024
www.mdpi.com/1422-0067/23...

Defective biomechanics of #hiPSC-cardiomyocyte with Filamin C truncated variant

"Mutant FLNC disrupts the diastolic relaxation phase in hiPSC-CMs"

PDGFRα inhibitor (Crenolanib) partially recovers adhesion but minimally affects cell stiffness

#IJMS_MDPI 2024
www.mdpi.com/1422-0067/25...