Integrative Mechanisms of Osteoprotegerin in Cardiovascular Pathophysiology Summarizing the molecular and clinical insights on the multifaceted role of Osteoprotegerin in cardiovascular diseases.

This #CVIA review describes osteoprotegerin as a key regulator of #VascularHomeostasis and #Inflammation, demonstrating that dysregulation of the OPG/RANKL/TRAIL axis drives #ArterialCalcification and adverse #CardiacRemodeling.

#OpenAccess: cvia-journal.org/osteoprotege...

Research Advances in the Mechanisms of Pannexin-1 Channels in Cardiovascular Diseases Exploring the structural and functional landscape of Panx1, detailing its regulation and its role in the pathophysiology of cardiovascular diseases.

This #CVIA review highlights the critical role of Pannexin-1 channels in modulating #Cardiovascular pathologies, emphasizing how regulated ATP release influences #CardiacRemodeling and #IschemiaReperfusionInjury.

#OpenAccess: cvia-journal.org/pannexin1-ca...

This review delineates the regulatory roles of the #CardiacTroponin subunits within the cTnC complex, detailing how molecular alterations in troponin subunits drive myofilament dysfunction and pathological #CardiacRemodeling.

#OpenAccess: doi.org/10.1016/j.ge...

Inflammation-Related Factors S100A9 and TLR2 in Cardiomyocyte Hypertrophy

A pathogenic S100A9–TLR2 feedback loop amplifies #hypertrophic and #InflammatorySignaling in mechanically stressed #cardiomyocytes, linking immune dysregulation to maladaptive #CardiacRemodeling and highlighting a therapeutic target in #HeartFailure.

Read: doi.org/10.1007/s115...

Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences | Circulation BACKGROUND: Vascular aging is an important phenotype characterized by structural and geometric remodeling. Some individuals exhibit supernormal vascular aging, associated with improved cardiovascular ...

Penn Medicine #BioBank growing its impact: Discerning early aortic #aging from imaging data with links to adverse #CardiacRemodeling and poor #CardiovascularOutcomes www.ahajournals.org/doi/10.1161/... @ThePMBioBank #PMBB #TranslationalScience

Mitophagy deficiency activates stimulator of interferon genes activation and aggravates pathogenetic cardiac remodeling

In this study, researchers show that #StimulatorofInterferonGenes (STING) contributes to #CardiacFibrosis, promotes adverse remodeling, and highlights STING as a potential therapeutic target for the prevention of #CardiacRemodeling induced by pressure overload. #medsky

#OpenAccess: buff.ly/CN3Dykn