Integrative Mechanisms of Osteoprotegerin in Cardiovascular Pathophysiology Summarizing the molecular and clinical insights on the multifaceted role of Osteoprotegerin in cardiovascular diseases.

This #CVIA review describes osteoprotegerin as a key regulator of #VascularHomeostasis and #Inflammation, demonstrating that dysregulation of the OPG/RANKL/TRAIL axis drives #ArterialCalcification and adverse #CardiacRemodeling.

#OpenAccess: cvia-journal.org/osteoprotege...

Metabolo-Epigenetic coupling #SmoothMuscleCell #ArterialCalcification

NR4A3 (⏫in calcified👤🐭aortas ) as a direct transcriptional activator of Glycolysis (ALDOA PFKL)

🤓Lactate ▶️Histone Lactylation H3K18la of PHOSPHO1 gene promoter▶️Calcification

#CircRes 2024
www.ahajournals.org/doi/10.1161/...

mTOR #ArterialCalcification
#Rapamycin almost Doubles lifespan 🤠 (T50 35->61 days) of Mgp KO🐭
An ectopic arterial calcification model with premature death
🤓WITHOUT impacting Aortic
1⃣Calcification
2⃣Elastin
3⃣Osteogenic vs Contractile phenotype
4⃣Autophagy

bioRxiv 2024
www.biorxiv.org/content/10.1...

#SmoothMuscleCell MMP3 mediates #ArterialCalcification in mice+Vitamin D3 (How?🧐)

MMP3 is the only MMP upregulated in calcifying rat aortic SMCs (Pi/Ca2+)

Raul Guzman lab #CardiovascRes 2024
academic.oup.com/cardiovascre...