🐁 Most sperm (around 80%) from knockout mice had a stiff midpiece, leading to restricted tail movement. This limited the sperm’s propulsive power, impairing their ability to swim effectively and reducing #fertilisation success.

#reproductivehealth  #spermatogenesis

- Medications targeting MAPK1 & MAPK14 are proposed as potential therapies to reduce COVID induced damage to #spermatogenesis
MAPK Pathway and Immune Dysregulation
- The MAPK pathway is an early responder in the innate immune response, likely activated

#Article in #MedComm
Longitudinal Analysis of Male Fertility Using an Acr-Luc Knock-In Mouse Model: A Preclinical Platform for Reproductive Toxicity Testing doi.org/10.1002/mco2...

#BioluminescenceImaging #MaleFertility #RReproductiveToxicity #Spermatogenesis

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat-stressed spermatogonial cells in vitro

👉 buff.ly/ZBKlHhu

#ERstress #Spermatogenesis #Salubrinal

Bitter taste signaling pathway is required for spermatogenesis and maintenance of male fertility in mice Abstract. Recently, the expression of bitter taste receptors and their downstream taste signaling cascade has been widely found outside the gustatory syste

📣”#BitterTaste signaling pathway is required for #spermatogenesis and maintenance of male #fertility in mice”

📚🔗Don’t miss this interesting article!
academic.oup.com/molehr/artic...

New research in #RESInsectMolecBio

ζTrypsin is required for spermatid elongation and individualization in #Drosophila #spermatogenesis
doi.org/10.1111/imb.70014

#Trypsin
@sassanasgari.bsky.social @gulianusslab.bsky.social @wiley.com

🪱The protein tyrosine phosphatase PPH-7 is required for fertility and embryonic development in C. elegans at elevated temperatures

🔗https://buff.ly/3HWEtDM

@spanglab.bsky.social

#Celegans #Phosphatases #Spermatogenesis #PTMs

Discover how the spermatid manchette, beyond its structural role, is vital as a transport scaffold in sperm development, shaping nuclear remodeling and cargo delivery in spermiogenesis. #CellBiology #Spermatogenesis @reviewcommons.org
www.life-science-alliance.org/content/8/10...

This study demonstrates that #Chlorpyrifos exposure compromises the #BloodTestisBarrier integrity via #clockophagy-mediated #ferroptosis, leading to abnormal #spermatogenesis. #maleinfertility #sertolicells #medsky

#OpenAccess:
www.sciencedirect.com/science/arti...

Sphingolipids and Male Reproductive Health: A Narrative Review of Their Roles in Spermatogenesis, Fertility, and Dysfunction - Reproductive Sciences Sphingolipids are bioactive lipids involved in cellular signaling and structural processes. Recent studies highlight their critical role in spermatogenesis, sperm functionality, and male infertility.…

Los esfingolípidos son unos lípidos de membrana muy especiales y con funciones indispensables para la reproducción masculina. Si quieres saber más, un revisión actualizada:
link.springer.com/article/10.1...
#bianorbiotech #MaleReproduction #Sphingolipids #spermatogenesis #fertility

DEHP induces a ROS-mediated imbalance in #pyroptosis and #mitophagy in immature rat testes via XBP1, suggesting that XBP1 might be the key target in DEHP-related testis dysfunction. #ERstress #spermatogenesis #medsky

#OpenAccess:
www.sciencedirect.com/science/arti...

Don’t miss next week’s Fragile Nucleosome seminar featuring @juliecocquet.bsky.social ⭐️ cool discussion about #DOT1L, #chromatin dynamics & #spermatogenesis guaranteed!

Excited to share my first first-author publication!
We mapped human CRISP2 during spermatogenesis and revealed its molecular organization in sperm.
Read here: doi.org/10.1093/biol...
#BiolReprod #ReproductiveBiology #Andrology #MaleFertility #Spermatogenesis #CRISP2 #SpermBiology

Graphical abstract of: Depletion of Gtsf1L impairs development of eupyrene sperm and ovary in Bombyx mori

New research published in #RESInsectMolecBio shows depletion of Gtsf1L impairs development of eupyrene sperm and ovary in #BombyMori🧬

Read the article now🔽
doi.org/10.1111/imb.12988

@sassanasgari.bsky.social @gulianusslab.bsky.social @wiley.com
#oogenesis #SexDetermination #spermatogenesis

Prenatal bisphenol A exposure causes sperm quality and functional defects via Leydig cell impairment and meiosis arrest in mice offspring - Scientific Reports Scientific Reports - Prenatal bisphenol A exposure causes sperm quality and functional defects via Leydig cell impairment and meiosis arrest in mice offspring

Bisfenol A y fertilidad. La exposición prenatal en un modelo de ratón provoca alteraciones en las células de Leydig y la espermatogénesis, con peor calidad seminal al llegar a la madurez sexual.
www.nature.com/articles/s41...
#bianorbiotech #BPA #MaleFertility #LeydigCells #spermatogenesis

New #spermatogenesis research from Penn Vet shows conserved gene regulatory networks in mouse & rat and chromatin accessibility changes with germ cell differentiation. ow.ly/kRHN50Vin6N
@isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social

An aberrant protamine ratio is associated with decreased H4ac levels in murine and human sperm Abstract. Protamine 2 (Prm2/PRM2), together with Protamine 1 (Prm1/PRM1), constitute the two protamines found in both murine and human sperm. During spermi

The findings reveal that PRM2 is necessary for maintaining specific histone post-translational modifications, such as #acetylation, essential for proper #spermatogenesis and particularly for proper chromatin #remodelling.

#EditorChoice
🔗📚👇
academic.oup.com/molehr/artic...

Meet the NYRA Board—Superheroes Edition!

Next up: Álvaro Pascual (aka Dr. Synapse) - 🧬⚡—decoding the secret choreography of homologous chromosomes during early spermatogenesis! 🔍✨
#Genetics #Spermatogenesis #SuperheroScience #NYRA

Empezamos la semana con ciencia básica sobre plásticos y fertilidad. En un modelo de ratón, la presencia de nanoplásticos de poliestireno afecta a la espermatogénesis alterando la expresión génica.
https://pubs.acs.org/doi/10.1021/acsnano.4c10701
#bianorbiotech #nanoplastics #spermatogenesis #Male…

Transcriptómica, espermatogénesis e infertilidad: una revisión sobre los ARN en el espermatozoide e influencia de la espermatogénesis y maduración.
https://buff.ly/4foTv3s
#bianorbiotech #MaleFertility #transcriptomics #RNA #epididymosomes #spermatogenesis

Los micro y nanoplásticos son un problema para la salud y la reproducción. Un artículo sobre transcriptómica en modelo de ratón:
https://buff.ly/4gbKADV
#bianorbiotetch #MaleFertility #spermatogenesis #nanoplastics #polystyrene

So proud that my research was published on Genes & Development! And we also got the cover 🎉🎉🎉

Check out our paper if you are curious about how differential mRNA processing is developmentally regulated as cells differentiate!

#germcells #drosophila #spermatogenesis #mRNA #stemcells

The newest threat to #fertility may be #microplastics in our #testicles lowering #spermatogenesis.

The consequences of #SARSCoV2 infection on the testis injury & function both during the acute stage of the disease . Most of the testicular impairments except testosterone levels were resolved within 4 wks, which is almost one #spermatogenesis cycle

www.biorxiv.org/content/10.1...

Redirecting

New publication: Longitudinal covariation of #testosterone and sperm quality across reproductive stages in the #zebrafinch. #bodycondition #bird #incubation #parentalcare #reproductivesuccess #spermatogenesis
https://doi.org/10.1016/j.yhbeh.2023.105388