Epigenetics Update - DOT1L provides transcriptional memory through PRC1.1 antagonism go.nature.com/4qh5aXB

Chen Davidovich and Omer Gilan (Monash University) reporting in Nat Cell Biol

#Epigenetics #DOT1L #PolyComb
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Gain deeper insights into gene regulation; epigenometech.com

Looking forward to speaking next week @fnucleosome.bsky.social seminar! #FragileNucleosome #chromatin #DOT1L #germcells

Don’t miss next week’s Fragile Nucleosome seminar featuring @juliecocquet.bsky.social ⭐️ cool discussion about #DOT1L, #chromatin dynamics & #spermatogenesis guaranteed!

Chromatin environment-dependent effects of DOT1L on gene expression in male germ cells - Communications Biology Epigenomic and transcriptomic analyses reveal that, during mouse spermatogenesis, the H3K79 methyltransferase DOT1L has opposite effects on autosomal and X-linked gene expression depending on local ch...

Super happy to see our latest work on the opposite effects of DOT1L on gene expression published !
#chromatin #DOT1L #sexchromosomes #malegermcells

www.nature.com/articles/s42...