#Cystatin C Confirms the #Canagliflozin eGFR Slope Benefit in #CANPIONE

#VisualAbstract by Edgar V. Lerma 🇵🇭

www.kireports.org/article/S2468-0249(26)02...

Canagliflozin Tied to Reduction in HbA1c in Children, Adolescents With T2D A greater proportion of participants achieved HbA1c levels below 6.5% with canagliflozin than with placebo.

#Canagliflozin is associated with a clinically meaningful reduction in #HbA1c for children and adolescents with #T2DM.

Read More: https://bit.ly/3KBT8sI

💊 Canagliflozin is a synthetic SGLT2i, it is the latest approved class of #medicine used in the treatment of type 2 #diabetes.

💊 This #Review article contains information about the #pharmacokinetics, #drug safety, and #efficacy profile of #canagliflozin.

💻 www.thieme-connect.com/products/ejo...

Cardiovascular outcomes of SGLT-2 inhibitors’ subtypes in type 2 diabetes; an updated systematic review and meta-analysis of randomized controlled trials - Journal of Diabetes & Metabolic Disorders Introduction The effects of Sodium-glucose cotransporter-2 (SGLT-2) inhibitors on cardiac outcomes, cardiovascular mortality (CVM), and all-cause mortality (ACM) in type 2 diabetes mellitus (T2DM) pat...

SGLT-2 inhibitors lower #death, #HeartAttacks, and #HeartFailure hospitalizations in type 2 #diabetes, with no effect on #stroke risk.
Key drugs: #Empagliflozin, #Canagliflozin, #Dapagliflozin.
#SGLT2 #HeartHealth #MetaAnalysis link.springer.com/article/10.1...

SGLT2i as #Senolytics
#Aging

#Canagliflozin restored the immune clearance (at least T cell) of senescent cells in HFD🐭#WhiteAdiposeTissue ▶️ improved glucose metabolism

Not a direct seno-killing effect
Instead, ⬆️AICAR-AMPK▶️ ⬇️PD-L1 in senescent cell

#NatureAging 2024
www.nature.com/articles/s43...

#SGLT2 #credence #canagliflozin Reduction Im hard endpoints. No increased #fracture nor #amputation @P_Rossing #nephroupdate19

#canagliflozin is safe 👏🏻👍🏽@ynptweets @eraedta #eraedta19

Picky, picky, picky.

#canagliflozin