Mesenchymal stromal cells induce neutrophil aggregation and extracellular vesicle storms for systemic lupus erythematosus - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Mesenchymal stromal cells induce neutrophil aggregation and extracellular vesicle storms for systemic lupus erythematosus

Scientists reveal that #MesenchymalStromalCell transplantation induces #BoneMarrow neutrophil aggregation to generate #ExtracellularVesicle storms, which balance Th17/Treg cells, drive immune tolerance, and predict therapeutic efficacy in #SLE.

#STTT: doi.org/10.1038/s413...

Demonstration of the safety and tolerability of #MesenchymalStromalCell therapy in patients with #DecompensatedLiverCirrhosis, providing the first human-based evidence on the dose‒effect relationship & optimal administration regimens.

#STTT #OpenAccess: doi.org/10.1038/s413...

Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis

MSC Therapy for DLC!

This Phase 1 clinical trial demonstrates the safety and tolerability of #MesenchymalStromalCell therapy in patients with decompensated liver cirrhosis, offering insights into its #immunomodulatory effects. #medsky

Read this #STTT #OpenAccess: www.nature.com/articles/s41...

I-domain of LFA1 (binding to ICAM1)-PAMAM dendrimer nanocarrier-coated #MesenchymalStromalCell targets Apoe-/- mouse atherosclerotic lesion (also liver, bladder, but not lung)

#FrontCVMedicine 2025
www.frontiersin.org/journals/car...

APOE as a destabilizer of Heterochromatin & driver of #Senescence in #MesenchymalStromalCell & Fibroblast

Nuclear ApoE directly binds & disintegrates #NuclearEnvelope via promoting autophagic-lysosomal degradation of NE/Heterochromatin proteins

#NatureAging 2022
www.nature.com/articles/s43...