Appreciate the peer review invitation by #FrontCVMedicine
Hope that I am not Reviewer 2 this time☺️

I-domain of LFA1 (binding to ICAM1)-PAMAM dendrimer nanocarrier-coated #MesenchymalStromalCell targets Apoe-/- mouse atherosclerotic lesion (also liver, bladder, but not lung)

#FrontCVMedicine 2025
www.frontiersin.org/journals/car...

Serum #YAP (+WBC, D-dimer) differentiates acute type A #AorticDissection (N=60) from #AcuteConronarySyndrome (N=50) in👤chest pain
Also ➕corr. post-op #MajorAdverseEvents

Dissection➡️Not only⏫ 1.5-fold YAP, but also⏫WBC, CRP, D-dimer

#AortaEd
#FrontCVMedicine 2024
www.frontiersin.org/journals/car...

ATACseq #Aorta #BicuspidAorticValve
2 Case + 2 heart transplant Ctrl

Re-analysis 4 Bulk RNAseq (BAV aorta or aortic SMC) + 1 scRNAseq (TAV)

6 Mesenchymal cell genes
⏫BAV
CD9
FHL1y (??)
HSP90AA1
⏬BAV
GAS6
PALLD
ACTA2

#FrontCVMedicine 2024
www.frontiersin.org/articles/10....

Methotrexate (#FolicAcid analog, anti-tumor drug) for 🐭#MarfanSyndrome (mgΔloxPneo, 129/sv)
i.p. with #LipidCoreNanoparticle, weekly

This🐭model features the most severe dilation at #AorticArch
1/3🐭dissect
Where #AorticDissection occurs?🧐

#FrontCVMedicine 2024
www.frontiersin.org/articles/10....