#Autophagy defect (Atg5 KO) & #ERStress in #SmoothMuscleCell⏫#AorticDissection #AorticRupture in🐭+Angiotensin II

Both features (LC3B, p62, GRP78/BiP) also⏫in👤#ThoracicAorticDissection

#ClonalExpansion of SMC in dissecting🐭aorta🤠
#ATVB 2019
www.ahajournals.org/doi/full/10....

#Aging+#TCell▶️#Atherosclerosis

An Aging Atlas of CD8+ T cells in🐭Spleen+Sorta (AAV-PCSK9+#WesternDiet)

#ClonalExpansion of GranZymeK+CD8+ #EffectorMemory T Cell in aged atherosclerotic plaque

Beautiful work🤩

Dan Tyrrell lab #NatureAging 2023
rdcu.be/drRn7

#SmoothMuscleCell #ClonalExpansion in Human #Atherosclerosis
♀️
X-linked inactiv. SMC-enriched BGN 3'UTR variant▶️clonal tracking

Clonality
Intimal 42%
Medial 18%

#Visium #SpatialTranscriptomics DEGs in clonal vs non-clonal SMCs🤠

Aloke Finn lab #ATVB 2023
www.ahajournals.org/doi/10.1161/...