M-cadherin regulates the formation of adherens junctions and secondary myofibers during fetal myogenesis to determine adult myofiber number and muscle mass Golann and colleagues found that predicted loss-of-function variants in the CDH15 gene (encoding M-cadherin) were associated with reduced lean mass. Similarly, CDH15KO mice displayed reduced muscle ma...

New #stemcellreports paper: M-cadherin regulates the formation of adherens junctions and secondary myofibers during fetal myogenesis to determine adult myofiber number and muscle mass. #Myoblue tinyurl.com/mubht234

¿Cómo el estómago humano puede fabricar insulina? Un avance que suena a terapia: células del estómago reprogramadas producen insulina en ratones y mejoran la glucosa. Detalles y datos clave. El avance es nítido y de alto calado biomédico: un equipo d...

¿Cómo el estómago humano puede fabricar insulina? #8denoviembre #felizsabado #DiabetesTipo1 #Insulina #Organoides #Ciencia #Salud #Investigación #Harvard #WeillCornell #Pekín #TerapiaCelular #MedicinaRegenerativa #StemCellReports

donporque.com/estomago-hum...

Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells In this manuscript, Sacco, Caputo, and colleagues demonstrate that modulation of the JAK2/STAT3 signaling pathway during in vitro myogenic differentiation promotes expansion of PAX7+ SMPCs in multiple...

New #stemcellreports paper: Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells. #Myoblue tinyurl.com/yyjhn94p

Delineating transcriptomic signatures of in vitro human skeletal muscle models in comparison to in vivo references In this article, Yilmaz and colleagues perform a large-scale transcriptomics metaanalysis with over 400 samples comparing established in vitro skeletal muscle models to in vivo skeletal muscle samples...

New #stemcellreports paper: Delineating transcriptomic signatures of in vitro human skeletal muscle models in comparison to in vivo references. #Myoblue tinyurl.com/mphh5u6j

Unraveling the matrisome signatures of quiescent and activated muscle stem cells The extracellular matrix (ECM) niche regulates skeletal muscle stem cell (MuSC) behavior. Using transcriptomic data and 3D imaging, they show that quiescent MuSCs express unique ECM markers, including...

New #stemcellreports paper: Unraveling the matrisome signatures of quiescent and activated muscle stem cells. #Myoblue tinyurl.com/ycyy3nw5

🔬 🧪The International Society for Stem Cell Research @isscr.org, in partnership with #StemCellReports @stemcellreports.bsky.social invites you to Athens, Greece, on 3-4 April 2025 for a unique symposium to explore the latest neural #StemCell research.

▶️ www.isscr.org/upcoming-pro...

Effect of Notch1 signaling on muscle engraftment and maturation from pluripotent stem cells In this report, Yamashita and colleagues investigate Notch1 signaling in PSC-derived iPax3 myogenic progenitors during muscle regeneration. Notch1 overexpression enhances myofiber maturation, while it...

New #stemcellreports paper: Effect of Notch1 signaling on muscle engraftment and maturation from pluripotent stem cells. #MyoBlue tinyurl.com/yn7fzafj

3D #BloodBrainBarrier #OrganOnAChip

#Microfluidic Fibrin

#hiPSC-#EndothelialCell
👤🧠Brain vascular #Pericyte (no apparent wrapping)
Primary or hiPSC-Astrocyte

Astrocyte⏫#VascularPermeability & Vascular length density, ⬇️by cAMP or flow

#StemCellReports 2024
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