Coffee and Dementia: Can Your Morning Cup Protect Your Brain? In today's episode we're exploring a landmark study of over 130,000 people to reveal the powerful link between Coffee and Dementia. We discuss how moderate coffee consumption - about one to two and a half cups daily—is associated with a 19% reduction in dementia risk. You will discover why caffeine is essential for these benefits, how it potentially blocks amyloid plaque formation, and why decaf coffee doesn't offer the same protection. We also share practical tips on the best time to drink your coffee to support long-term brain health. References: https://jamanetwork.com/journals/jama/article-abstract/2844764 https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.70235 Support our work. Make a small donation. Support our work. Make a small donation. This removes any advertisements and help us continue bringing more interesting topics and confronting mainstream narrative on health. Click the Link to support us: https://www.spreaker.com/podcast/foodnourish-deep-dives--6602003/support

📣 New Podcast! "Coffee and Dementia: Can Your Morning Cup Protect Your Brain?" on @Spreaker #adenosine #alzheimers #antioxidants #brain #caffeine #coffee #cognitive #dementia #health #inflammation #longevity #memory #neuroprotection #nutrition #plaque #prevention #science #study #tea #wellness

This morning, @egorxen.bsky.social @utu.fi #adenosine modulates sensation mappings and subjective #emotion ratings, providing a first look at their total-body #PET analyses! ⭐️

#neuroskyence #neuroscience #MindBrainBody #interoception

#MBBS2026 #MBB

What if during a traumatic event, the brain's inner narrator becomes overwhelmed with the sensory and emotional data, shutting down?

What if later processing of the scattered data fragments trigger meltdowns because it is genuinely the first time the PFC has interacted with them?

#Adenosine

#Paniekaanval OF #Cardiovasculair ?

🫀 #INOCA #ANOCA #MINOCA 🫀
#CMD #CAS #MVA #VSA
#Endothelial #Dysfunction
#Coronary #Vasospasm
#MicrovascularDysfunction
#NOCAD
#coronary #FUNCTION #TESTING ❗️
#Acetylcholine #Adenosine

#Hormoonschommelingen
#MenstrueleCyclus
#Perimenopause

#ANOCA 🫀

#Endotypes #Prevalence ❗
#Diagnosis #Treatment

#CAS #VSA #CMD #MVA ❤️‍🩹
#EndothelialDysfunction
#MixedEndotypes

#CoronaryFUNCTIONtesting
#Adenosine #Acetylcholine

2/2

https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf839/8320199?login=false

#ANOCA 🫀
= Angina (pectoris) with Non-Obstructive Coronary Arteries ❤️‍🩹

#Endotypes #Prevalence❗
#Diagnosis #Treatment

#CAS #VSA #CMD #MVA ❤️‍🩹
#EndothelialDysfunction
#MixedEndotypes

#CoronaryFUNCTIONtesting
#Adenosine #Acetylcholine

t.co/xJskm7u0Od

#ANOCA #INOCA #MINOCA #NOCAD 🫀

#Diagnosis #Endotypes #Treatment

#CAS #VSA #CMD #MVA ❤️‍🩹
#EndothelialDysfunction #MyocardialBridging

#MixedEndotypes

#CoronaryFUNCTIONtesting
#Adenosine #Acetylcholine

1/2

Gerald M. Herrera from uvmlarnermed.bsky.social et al. observed that #adenosine and acute low oxygen conditions suppress #urinary bladder contractility through the activation of adenosine 2B receptors and large-conductance BKCa channels 🔎 ⤵️

📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

What if our brains were like running a car in the garage with just a window open?

What if doing hard tasks brains aren't optimized for was revving the engine more than the exhaust can breathe out the window?

Can you complete tasks before your brain blacks out?

#ASD #AutisticBurnout #Adenosine

A Promising Path Forward in Obesity Pharmacotherapy: Ecnoglutide and the Evolution of GLP-1R Agonist Design Announcing a new article publication for BIO Integration journal.  This article reviews robust evidence from a large, multicenter, randomized, placebo-controlled study in Chinese adults with overweigh...

A randomized clinical trial exploring the efficacy of #ecnoglutide, a novel cyclic #adenosine #monophosphate (cAMP)-biased #GLP-1RA, in #obesity without diabetes.

#OpenAccess: bio-integration.org/glp1ra-ecnog...

📢 Save the date! 3rd European Purine Meeting
🗓️ 1–3 July 2026 |
📍 Bordeaux, France (Univ. Bordeaux, Campus Victoire)

Preceded by the final PRESTO meeting: 30 June–1 July 2026
🌐 Call for Symposia now open: live.eventtia.com/en/european-...

#P1 #P2X#P2Y #ATP #adenosine #purinergic #signalling

Caffeine blocks adenosine, the same pathway used by fast-acting depression treatments Perhaps the most intriguing implication of recent breakthrough research lies in an unexpected connection: the most rigorous mechanistic dissection of rapid antidepressant action identifies adenosine a...

🫘 Caffeine blocks adenosine, the same pathway used by fast-acting depression treatments

medicalxpress.com/news/2025-11...

#caffeine #brain #neuroscience #depression #antidepressants #pharmacology #adenosine

Adenosine in the Brain: Recent Progress on Detection, Function, and Translation Although adenosine was identified in the brain many decades ago, our understanding of when, where, and how it functions has expanded rapidly in recent years, driven in part by innovative technological...

At #SfN25 in San Diego this week? #Adenosine fans, this one is for you! Catch Dr. Kathryn Todd at MIN40 | Room 6CR on Wednesday at 2:30 pm PST!

Want more? Dive deeper with the must-read review by the full group of speakers and chairs!

@stephcragg.bsky.social

Caffeine blocks #Adenosine (the chemical that makes you feel sleepy). A brief nap helps clear adenosine first, so when you wake up, the caffeine has more open receptors to bind to, yielding a cleaner, stronger lift.

CD39 and CD73: biological functions, diseases and therapy - Molecular Biomedicine Cluster of differentiation 39 (CD39) and CD73 are ectonucleotidases that play pivotal roles in purinergic signaling. CD39 catalyzes the hydrolysis of adenosine triphosphate (ATP) to adenosine diphosph...

#Review
#CD39 and #CD73: biological functions, diseases and therapy doi.org/10.1186/s435...

#Adenosine #Function #Disease #Therapy

Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.

💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF

Online now - the Spotlight " #SAMcycle and #adenosine at the heart of immune conversations" from Tina Mukherjee and colleagues.

#macrophages #infection #immunometabolism #SAMtransmethylation

authors.elsevier.com/a/1lHcd3S6Gf...

Cortiswole (1/2)

A guide on how to max your adenosine and cortisol. Get your brain jacked 'n' swole.

#wellness #routine #huberman #cortisol #adenosine #coffee #morningcoffee #comic #webcomic #influencer

Introducing HypnoS—A high-performance fluorescent sensor spatiotemporally reveals cell-type specific regulation of intracellular adenosine in vivo

🔗 Insight into the Nature Communications article：
www.ebraincase.com/support/lite...

#Neuroscience #Adenosine #LiveImaging #Sleep #Seizure #HypnoS

Research seminar in #Sheffield
Tues 13th May

Come and learn about #astrocytes #adenosine #metabolism

Shefeeq Theparambil is a stunning scientist and definitely one to watch 💫

Adénosine de la chatte

L'adénosine est un nucléoside formé d'une molécule de ribose liée à une base azotée, la purine adénine, jouant un rôle crucial dans le métabolisme cellulaire et la signalisation cellulaire. #Adenosine #Ribose #Metabolisme #Signalisation #Nucléoside

Adenosine acts as a signaling molecule, influencing heart function, nerve transmission, and blood vessel dilation. It's antithetical to caffeine. It's used medically to treat irregular heart rhythms and in cardiac stress tests.

#adenosine #caffeine #sleep #rest #molecule

9/ #Adenosine reminds us how deeply connected our energy, #sleep, and habits are.

It’s the molecular maestro orchestrating our need for rest. And while #caffeine can offer a temporary boost, there’s no substitute for the real, restorative power of sleep.

8/ This #adaptation is why you might need more #caffeine over time to feel the same buzz.

It’s also why skipping your daily dose can leave you feeling even #sleepier than before—those extra #adenosine receptors are now unoccupied and signaling for #rest.

7/ When #adenosine can’t bind to its receptors, your #neurons fire faster, your alertness skyrockets, and #adrenaline kicks in, keeping you awake and energized.

But there’s a catch: as you consume #caffeine regularly, your brain adapts by creating more adenosine receptors.

6/ Now, let’s talk #caffeine! Ever wonder how your favorite coffee or tea keeps you alert?

Caffeine works by blocking #adenosine receptors, preventing molecule from signaling your #brain to slow down.

Essentially, caffeine hijacks adenosine's seat & keeps the #energy flowing.

3/ The longer you stay awake, the more #adenosine accumulates in your #brain.

This rising level acts like a gentle nudge toward rest, interacting with A1 and A2A receptors to inhibit #wakefulness.

It’s your body’s way of saying, “Hey, it’s time to recharge!”

2/ This fascinating molecule is a byproduct of ATP, the #energy currency in your cells.

As your #brain works hard, ATP breaks down, and #adenosine builds up, creating "#sleep pressure".