Winner of the 2025 Creager Prize: "Pilot study to evaluate the safety & effectiveness of etidronate treatment for arterial calcification due to deficiency of #CD73 (#ACDC)" by Ferrante et al.
doi.org/10.1177/1358...
#12DaysofVascularMedicine #rarediseases

CD39 and CD73: biological functions, diseases and therapy - Molecular Biomedicine Cluster of differentiation 39 (CD39) and CD73 are ectonucleotidases that play pivotal roles in purinergic signaling. CD39 catalyzes the hydrolysis of adenosine triphosphate (ATP) to adenosine diphosph...

#Review
#CD39 and #CD73: biological functions, diseases and therapy doi.org/10.1186/s435...

#Adenosine #Function #Disease #Therapy

Kristýna Blažková se společně s kolegy z vědeckých skupin Jana Konvalinky a @hoceklab.bsky.social zaměřila na enzym #CD73, který využívají nádorové buňky k útlumu imunitního systému tak, aby nebyl schopný bránit rakovinnému bujení. 3/7

A recent study found that women undergoing cardiac surgery show reduced CD39/CD73 expression and greater #fibrosis. Using a #CD39 mimetic and #CD73 enhancer improved cardiac function and reduced fibrosis in an ovariectomy + high-fat diet mouse model.

Read more: www.sciencedirect.com/science/arti...

Dr. Seems Aceves shared a beautiful and complex story about eosinophilic esophagitis in the lab and the clinic!

Her deep dive story included the markers #CD73 and #YAP, muscular rigidity, and the possibility that there’s more the #EoE than previously thought 🧐