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Our latest preprint describing a new source for lymphatic endothelial cells is now out!

www.biorxiv.org/content/10.6...

We show that a Csf1r lineage gives rise to a large subset of dermal #lymphatics in the embryo that persist into adulthood and are essential for normal development.

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ICYMI: this collection highlights the latest JEM studies in lymphatic biology, incl. studies on lymphatic vessels in the skin, skull, intestine, and lung, novel imaging techniques, and the role of lymphatic vessels in various pathologies. rupress.org/jem/collecti...

#Lymphatics

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Convergent evolution of scavenger cell development at brain borders - Nature Transcription factor osr2 is identified as a specific marker and regulator of mural lymphatic endothelial cell (muLEC) differentiation and maintenance, and muLECs and border-associated macrophages sha...

As ever, the #Lymphatics GRC meeting has been wonderful! Really high quality talks and posters, and it's been great to see so many @jem.org studies highlighted! ✨ For #JEMjc I'd like to share recent work from @benjhogan.bsky.social - fascinating stuff! www.nature.com/articles/s41...

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The cribriform plate: A dynamic central nervous system immune hub. Review from Collin J. Laaker, Zsuzsanna Fabry and colleagues: rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

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Amyloidosis of bridging veins is a pathologic feature of #Alzheimers disease, from @leonsmyth.bsky.social, Rupal Mehta, @jonykipnis.bsky.social et al. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

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Xin Geng, Michael Davis, Sathish Srinivasan and colleagues show that S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

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I was honoured to be one of the two presenters awarded for the best scientific talk at the GRS Lymphatics 2026!
I must say I'm as grateful as I'm still stunned!
Glad to share our work from Ruhrberg lab at this GRS/GRC showing a Csf1r lineage contribution to dermal #lymphatics

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@simoncleary.bsky.social, Longhui Qiu, Mark Looney et al. developed a new #intravital technique for imaging pulmonary lymphatics. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

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Intestinal lymphatic vasculature is functionally adapted to different drainage regions and is altered by #helminth infection. From Jorden Lane, Daria Esterházy and colleagues: rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

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A novel #zebrafish model from @karinayaniv.bsky.social et al. provides a powerful platform to dissect kaposiform lymphangiomatosis (KLA) pathogenesis and identify new therapeutic avenues. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

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Qing Chang, Jian-Fu Chen et al. show lymphatic vessels are present in the skull periosteum but absent in bone marrow, with channel and bone marrow heterogeneity varying by skull region and age. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

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Bauer et al. @halinlab.bsky.social reveal how the structure and cellular morphology of human dermal afferent lymphatic vessels differ from the current, primarily mouse tissue–based textbook description. rupress.org/jem/article/...

📘 In our #Lymphatics collection: rupress.org/jem/collecti...

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Are you attending the GRC meeting on #Lymphatics in Italy and interested in discussing your work with a JEM editor? Get in touch with JEM's Senior Editor Lucie Van Emmenis (@lucie-jexpmed.bsky.social) who will be there!
📩 Email Lucie: rupress.org/jem/pages/ed...

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Explore the latest discoveries @jem.org in lymphatic biology, incl. studies on lymphatic vessels in the skin, skull, intestine & lung, novel imaging techniques, & the role of lymphatic vessels in various pathologies. New research to accompany the GRC #Lymphatics meeting: rupress.org/jem/collecti...

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Explore the latest discoveries in lymphatic biology, incl. studies on lymphatic vessels in the skin, skull, intestine & lung, novel imaging techniques, & the role of lymphatic vessels in various pathologies. New research to accompany the upcoming GRC #Lymphatics meeting: rupress.org/jem/collecti...

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Ahead of the upcoming #Lymphatics GRC meeting, for #JEM_Spotlight this month I would like to highlight this 2025 study from Jian-Fu Chen @ccmb.usc.edu where his lab identifies lymphatic vessels in the skull periosteum 🧠 Take a look here: doi.org/10.1084/jem....

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The physiology of thoracic duct pressure and flow: A review of the literature The thoracic duct (TD) is the largest vessel of the lymphatic system, transporting interstitial fluid, macromolecules, and immune cells into the venous circulation via the lymphovenous junction.…

This systematic #review on the effects of #respiration and #circulation on #thoracic duct #lymph flow and pressure in #humans and non-human #mammals highlights needs for modern #imaging and standardised physiological #protocols.
doi.org/10.14814/phy...
#Lymphatics

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Identification of lymphatic vessels in skull periosteum but not bone marrow reveals skull channel heterogeneity, from Qing Chang, Jian-Fu Chen and colleagues 👉 rupress.org/jem/article/...

📘 Part of 2025: The Year in Experimental Medicine: rupress.org/jem/collecti...

#Lymphatics

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New findings from Kurz, Lütge, Ludewig et al. indicate that CCL19-expressing perivascular progenitors are capable of generating the fibroblastic and mural cell infrastructure of murine lymph nodes. rupress.org/jem/article/...

#LymphocyteBiology #Lymphatics

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ICYMI: Read the latest #neuroscience research in JEM! The collection highlights the latest discoveries in meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...

#SfN25

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New findings from Bauer, Halin et al. @ethz.ch reveal key differences between human and murine dermal afferent #lymphatics and provide a deeper understanding of human lymphatic-related (patho)physiological processes: rupress.org/jem/article/...

#CardiovascularBiology #InnateImmunity #inflammation

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It was a great pleasure to be a part of this new study from @halinlab.bsky.social focusing on the #Lymphatics in human skin!

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Check out our new study in @jem.org on #Lymphatics using #SingleCell and #3DImaging in human skin, revealing new features of the lymphatic vascular system in #HumanBiology!

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Transcriptomics- and 3D imaging–based characterization of the lymphatic vasculature in human skin | Journal of Experimental Medicine | Rockefeller University Press This study reveals how the structure and cellular morphology of human dermal afferent lymphatic vessels differ from the current, primarily mouse tissue–bas

We are so excited to announce that our latest paper is out in @jem.org

By combining single-cell RNA sequencing and 3D imaging, we reveal striking structural and molecular differences between human and mouse dermal lymphatic vasculature, opening up new perspectives on #Lymphatics and #HumanBiology

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🧠 Read our new #Neuroscience collection of research articles and reviews to accompany #SfN25 @sfn.org! Explore the latest discoveries in #neuroscience, including meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...

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🧠 Read @jem.org's #Neuroscience collection of research articles and reviews to accompany #SfN25 @sfn.org! Explore the latest discoveries in #neuroscience, including meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...

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Transcriptomics- and 3D imaging-based characterization of the lymphatic vasculature in human skin. New study from Aline Bauer, Cornelia Halin and colleagues @ethz.ch: rupress.org/jem/article/...

#CardiovascularBiology #InnateImmunity #inflammation #Lymphatics

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New @jem.org study from Bauer, Halin et al. @ethz.ch reveals how the structure and cellular morphology of human dermal afferent lymphatic vessels differ from the current, primarily mouse tissue–based textbook description. rupress.org/jem/article/...

#Lymphatics

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New study from Bauer, Halin et al. @ethz.ch reveals how the structure and cellular morphology of human dermal afferent lymphatic vessels differ from the current, primarily mouse tissue–based textbook description. rupress.org/jem/article/...

#Lymphatics

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Vascular and Lymphatic Dysregulation via Non-EndoMT Col2a1 Signaling in Bisphosphonate-Related Osteonecrosis of the Jaw Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the most severe complications of antiresorptive therapy. Although impaired angiogenesis is commonly observed in BRONJ, the underlying ...

www.biorxiv.org/cgi/content/...
#bonehealth #osteonecrosis #BRONJ #vascularbiology #lymphatics

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