Convergent evolution of scavenger cell development at brain borders - Nature Transcription factor osr2 is identified as a specific marker and regulator of mural lymphatic endothelial cell (muLEC) differentiation and maintenance, and muLECs and border-associated macrophages sha...

As ever, the #Lymphatics GRC meeting has been wonderful! Really high quality talks and posters, and it's been great to see so many @jem.org studies highlighted! ✨ For #JEMjc I'd like to share recent work from @benjhogan.bsky.social - fascinating stuff! www.nature.com/articles/s41...

IgA-driven neutrophil activation underlies severe dengue disease after primary Zika virus infection in humans - Nature Immunology This study reveals that anti-NS1 IgA antibodies in plasma, induced by prior Zika virus infection, activate neutrophils, underlying severe dengue disease upon a subsequent DENV2 infection, uncovering a...

For this month #JEMjc we would like to highlight this study from Eva Harris lab linking anti-NS1 IgA antibodies in plasma from a primary ZIKV infection, to drive neutrophil activation and correlate with increased risk of subsequent severe DENV2 disease. More here:
www.nature.com/articles/s41...

Neutrophils preserve energy storage in sympathetically activated adipocytes - Nature Neutrophil-derived IL-1β has a role in preserving lipid stores during metabolic stress.

Today’s #JEMjc @jem.org highlights the work of Alan Saltiel & colleagues @nature.com reporting the role of neutrophil-derived IL-1β in preserving lipid stores during metabolic stress.

www.nature.com/articles/s41...

Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential Tissue macrophages reside in anatomically distinct subtissular niches that shape their identity and function. In white adipose tissue (WAT), we identified three macrophage populations with distinct lo...

For September’s #JEMjc we would like to highlight the recent description of septal macrophages controlling adipocyte tissue plasticity www.science.org/doi/10.1126/...

The gut microbiota promotes pain in fibromyalgia Cai et al. revealed that transplanting gut microbiota from women with fibromyalgia—a chronic widespread pain condition of unknown etiology—into mice induces pain. It also induces phenotypes commonly o...

For #JEMjc this month, @jem.org would like to highlight the recent work from Dr. Arkady Akhoutorsky @mcgill.ca and colleagues who identified a role for gut microbiota in mediating pain in fibromyalgia. Check it out here 👉 www.cell.com/neuron/fullt...

At today’s #JEMjc, we discussed three interesting studies about #Treg differentiation as well as function during #inflammation, #homeostasis and #regeneration.
@cp-immunity.bsky.social
www.nature.com/articles/s41...
www.cell.com/immunity/ful...
www.science.org/doi/10.1126/...