Inhibitory receptor agonists: Emerging strategies in immune modulation. New review form Kieran R. Adam, Aamir Suhail, Vijay K. Kuchroo @harvardmed.bsky.social, and
Dario A.A. Vignali (University of Pittsburgh School of Medicine):
rupress.org/jem/article/...
#Autoimmunity #LymphocyteBiology
In this review @jem.org, Adam, Suhail, Kuchroo, and Vignali highlight the challenges and novel approaches to developing agonistic inhibitory receptor (IR)-targeted therapies to treat #autoimmunity and inflammatory disorders.
rupress.org/jem/article/...
#CancerFocus #LymphocyteBiology
In this review, Adam, Suhail, Kuchroo, and Vignali highlight the challenges and novel approaches to developing agonistic inhibitory receptor (IR)-targeted therapies to treat #autoimmunity and inflammatory disorders.
rupress.org/jem/article/...
#CancerFocus #LymphocyteBiology
Allergic airway reactions rewired by PI3Kδ mutation. Lawrence Kane discusses new study from Golec et al. (rupress.org/jem/article/...), in Insights: rupress.org/jem/article/...
#Immunodeficiency #LymphocyteBiology
A PI3Kd-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation. New study from Dominic P. Golec, Pamela L. Schwartzberg and colleagues @niaidnews.bsky.social: rupress.org/jem/article/...
#Immunodeficiency #LymphocyteBiology
Next-generation #CRISPR screens enable causal systems #immunology. New Perspective from Hao Shi and Hongbo Chi @stjuderesearch.bsky.social: rupress.org/jem/article/...
#LymphocyteBiology #TumorImmunology
Insights @jem.org: Kane provides commentary on a new study from Golec et al. (rupress.org/jem/article/...), which reports that a mutation of PI-3 kinase underlying APDS impairs type 2 immunity. rupress.org/jem/article/...
#Immunodeficiency #LymphocyteBiology
Insights: Kane provides commentary on a new study from Golec et al. (rupress.org/jem/article/...), which reports that a mutation of PI-3 kinase underlying APDS impairs type 2 immunity. rupress.org/jem/article/...
#Immunodeficiency #LymphocyteBiology
A PI3Kd-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation. New study in @jem.org from Dominic P. Golec, Pamela L. Schwartzberg and colleagues @niaidnews.bsky.social: rupress.org/jem/article/...
#Immunodeficiency #LymphocyteBiology
Nasal germinal centers and IgA class switch recombination depend on CCR6 and B cell receptor affinity. New study from Jingjing Liu, Liat Stoler-Barak, and Ziv Shulman @zivshulman.bsky.social (Weizmann Institute): rupress.org/jem/article/...
#LymphocyteBiology
DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. New study from Emily Siniscalco, Courtney Fisher, Meng-Ping Lu, Stephanie Eisenbarth @yaleschoolofmed.bsky.social, Uthaman Gowthaman @umasschan.bsky.social and colleagues: rupress.org/jem/article/...
#LymphocyteBiology
Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers, say Yuliang Wang, Xinyi Yang, Yunli Wang, Xiaoming Wang, Jingjing Chen (Nanjing Medical University) and colleagues: rupress.org/jem/article/...
#LymphocyteBiology #Epigenetics #Metabolism
Siniscalco, Fisher, Lu, Eisenbarth, Gowthaman et al. reveal that DOCK8 and STAT3 cooperate in CD4⁺ T cells to restrain Tfh13 differentiation and prevent food-specific IgE. rupress.org/jem/article/...
#LymphocyteBiology #MucosalImmunology #HumanDiseaseGenetics
In @jem.org, Yuliang Wang, Xinyi Yang, Jingjing Chen et al. demonstrate CD205 is upregulated in pre-plasma cells. The H3K27 demethylase Kdm6b, not Kdm6a, allows prePCs to become bona fide PCs by removing H3K27me3 marks at the Irf4 locus. rupress.org/jem/article/...
#LymphocyteBiology #Epigenetics
Yuliang Wang, Xinyi Yang, Jingjing Chen et al. demonstrate CD205 is upregulated in pre-plasma cells. The H3K27 demethylase Kdm6b, not Kdm6a, allows prePCs to become bona fide PCs by removing H3K27me3 marks at the Irf4 locus. rupress.org/jem/article/...
#LymphocyteBiology #Epigenetics #Metabolism
FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells, say Carlota Farré Díaz, Eleni Kabrani, Klaus Rajewsky and colleagues @mdc-berlin.bsky.social: rupress.org/jem/article/...
#LymphocyteBiology
FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis. New study from Liling Xu, Facundo D. Batista and colleagues @ragoninstitute.bsky.social: rupress.org/jem/article/...
#LymphocyteBiology #Metabolism #Autophagy #Mitophagy
Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood, say Gabrielle LeBlanc, Adam Sobel, Michael Constantinides (@mikerobe.bsky.social) and colleagues @scripps.edu: rupress.org/jem/article/...
#InfectiousDisease #HostDefense #MucosalImmunology #LymphocyteBiology #Microbiome
New study from the Ye Zheng lab @salkinstitute.bsky.social and colleagues uncovers an essential role of REV-ERB in the regulation of colonic RORγt⁺Foxp3⁺ Treg cell differentiation and function. rupress.org/jem/article/...
#Tolerance #Autoimmunity #LymphocyteBiology
Rhodehouse, Siliciano @jhu.edu and colleagues show that, in a nonhuman primate (NHP) model, natural control can be nearly as effective as antiretroviral therapy in controlling viral replication. rupress.org/jem/article/...
#Virology #LymphocyteBiology #InfectiousDisease #HostDefense
Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect. New study from Kyle Rhodehouse, Robert F. Siliciano @jhu.edu and colleagues: rupress.org/jem/article/...
#Virology #LymphocyteBiology #InfectiousDisease #HostDefense
#Notch interaction with RUNX factors regulates initiation of the T-lineage program, say Yuichi Kama, Tomoaki Tanaka (Chiba University), Hiroyuki Hosokawa (Tokai University) and colleagues: rupress.org/jem/article/...
#LymphocyteBiology #Hematopoiesis #Immunology
New findings from Kurz, Lütge, Ludewig et al. indicate that CCL19-expressing perivascular progenitors are capable of generating the fibroblastic and mural cell infrastructure of murine lymph nodes. rupress.org/jem/article/...
#LymphocyteBiology #Lymphatics
Rhodehouse, Siliciano @jhu.edu and colleagues characterize a nonhuman primate model of natural control of SIV infection in which the immune system blocks new infection events with an efficiency approaching that of antiretroviral therapy. rupress.org/jem/article/...
#Virology #LymphocyteBiology
Kama, Tanaka, Hosokawa et al. show that #Notch-mediated reorganization of Runt-related transcription (RUNX) complexes and redeployment of RUNX-binding genomic regions are crucial for triggering the T-lineage program. rupress.org/jem/article/...
#Hematopoiesis #LymphocyteBiology #Immunology
In @jem.org, Kama, Tanaka, Hosokawa et al. show that #Notch-mediated reorganization of Runt-related transcription (RUNX) complexes and redeployment of RUNX-binding genomic regions are crucial for triggering the T-lineage program. rupress.org/jem/article/...
#Hematopoiesis #LymphocyteBiology
A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes, say Lisa Kurz, Mechthild Lütge, Burkhard Ludewig and colleagues (Cantonal Hospital St. Gallen): rupress.org/jem/article/...
#LymphocyteBiology
Vobořil, Hogquist @cfi-umn.bsky.social and colleagues reveal the #thymus as a niche for diverse, developmentally distinct #myeloid cells and elucidate their specific requirements for development and maturation. rupress.org/jem/article/...
#Hematopoiesis #Tolerance #LymphocyteBiology
New study from Bianchi, Foli, Mostanfar, Monticelli and colleagues establishes FCRL3 as a functional immunoregulatory receptor that restrains the activation of highly specialized human memory T cells. rupress.org/jem/article/...
#LymphocyteBiology
Thymic myeloid cells are heterogenous and include a novel population of transitional #DendriticCells, say Matouš Vobořil, Kristin A. Hogquist @cfi-umn.bsky.social and colleagues: rupress.org/jem/article/...
#Hematopoiesis #Tolerance #LymphocyteBiology
