Vascular smooth muscle cells are the underrated shapeshifters driving plaque evolution. Our new review unpacks how mechanics, molecular signals, and RNA regulation push vSMCs toward phenotypes that fuel plaque growth and vulnerability.
#Atherosclerosis #VascularBiology #SmoothMuscleCells
Hormonal influence: unraveling the impact of sex hormones (Estrogen Androgen Progesterone) on vascular #SmoothMuscleCells
Vascular aging
Atherosclerosis
Abdominal aortic aneurysm
Pulmonary arterial hypertension
Vascular calcification
#BioRes 2024
biolres.biomedcentral.com/articles/10....
This review highlights how #HDACs regulate endothelial and #SmoothMuscleCells and contribute to #Vascular #Pathogenesis. It also explores the therapeutic promise of HDAC inhibitors in #VascularDiseases. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
Smooth muscle cell calcineurin is required for angiotensin-II-induced abdominal aortic aneurysm formation. Representative images of hematoxylin–eosin (top row), Masson trichrome (middle row), and Van Gieson (bottom row) staining on abdominal aorta sections from calcineurin control mice (left), mice conditionally lacking calcineurin in endothelial cells (middle), and mice conditionally lacking calcineurin in smooth muscle cells (right), with and without angiotensin-II treatment.
Calcineurin is a phosphatase implicated in AngII-induced abdominal aortic #aneurysm (AAA). This study reveals a novel, phosphatase-independent mechanism by which #Calcineurin contributes to AAA, dependent on transcriptional reprogramming of #SmoothMuscleCells @plosbiology.org 🧪 plos.io/4kfnT3L
Smooth muscle cell calcineurin is required for angiotensin-II-induced abdominal aortic aneurysm formation. Representative images of hematoxylin–eosin (top row), Masson trichrome (middle row), and Van Gieson (bottom row) staining on abdominal aorta sections from calcineurin control mice (left), mice conditionally lacking calcineurin in endothelial cells (middle), and mice conditionally lacking calcineurin in smooth muscle cells (right), with and without angiotensin-II treatment.
Calcineurin is a phosphatase implicated in AngII-induced abdominal aortic #aneurysm (AAA). This study reveals a novel, phosphatase-independent mechanism by which #Calcineurin contributes to AAA, dependent on transcriptional reprogramming of #SmoothMuscleCells @plosbiology.org 🧪 plos.io/4kfnT3L
Smooth muscle cell calcineurin is required for angiotensin-II-induced abdominal aortic aneurysm formation. Representative images of hematoxylin–eosin (top row), Masson trichrome (middle row), and Van Gieson (bottom row) staining on abdominal aorta sections from calcineurin control mice (left), mice conditionally lacking calcineurin in endothelial cells (middle), and mice conditionally lacking calcineurin in smooth muscle cells (right), with and without angiotensin-II treatment.
Calcineurin is a phosphatase implicated in AngII-induced abdominal aortic #aneurysm (AAA). This study reveals a novel, phosphatase-independent mechanism by which #Calcineurin contributes to AAA, dependent on transcriptional reprogramming of #SmoothMuscleCells @plosbiology.org 🧪 plos.io/4kfnT3L
Aortic Smooth Muscle-On-A-Chip
18-well
#SmoothMuscleCells stretched on PDMS membrane + Vacuum pressure
6 Mitochondrial endpoints simultaneously
NADH/NAD+
Succinate
Cytochrome C
ATP
ROS
Membrane potential
Biosens Bioelectron 2024
www.sciencedirect.com/science/arti...
#AgilleSyndrome #CaseReport
Infant
Bilateral Pulmonary Artery Stenosis (⏬diameter, wall thickness)
Near complete dedifferentiation of medial #SmoothMuscleCells (or replaced by ACTA2-neg cells?😬) but seemingly supernumerary elastic lamina
#CVpathol 2024
www.sciencedirect.com/science/arti...
#Piezo1 drives Mechano-Aging of #SmoothMuscleCells
🐭Aortic SMC 3 mo vs 1 yr
Single-cell spatiotemporal force measurement by
#UltrasoundTweezer PDMS #MicropillarArray
#InstantaneousFrequencySpectrumAnalysis #HilbertHuangTransform
#AgingCell 2023
onlinelibrary.wiley.com/doi/10.1111/...
Exuberant contractile-to-synthetic phenotypic switch of #SmoothMuscleCells in #SpiralArtery in #PreEclampsia patients
+Excess #MitochondriaFission, not fusion
+Dysregulated mito Ca2+
Xiyuan Lu lab bioRxiv 2023
www.biorxiv.org/content/10.1...
Phenotypic Switching of Vascular #SmoothMuscleCells in #Atherosclerosis
Now we have 9 SMC phenotypes!?🤪
A nice synthesis of recent single-cell omics & SMC lineage tracing+KO mouse studies
Shu Ye lab #JAHA 2023
www.ahajournals.org/doi/10.1161/...
