FK506 binding protein 12.6-mediated inhibition of sperm-specific calcineurin is essential for FK506-induced male infertility by disturbing the homeostasis of calcium and mitochondria - Molecular Biome... Impaired sperm motility is a leading cause of male infertility. Studies indicated that FK506, an immunosuppressive drug, resulted in male mouse infertility or an overall decline in the fertilization c...

#Researh
#FK506 binding protein 12.6-mediated inhibition of sperm-specific calcineurin is essential for FK506-induced male infertility by disturbing the #homeostasis of #calcium and #mitochondria
doi.org/10.1186/s435...

#MaleiInfertility #FKBP #Calcineurin #CalciumRelease

Smooth muscle cell calcineurin is required for angiotensin-II-induced abdominal aortic aneurysm formation. Representative images of hematoxylin–eosin (top row), Masson trichrome (middle row), and Van Gieson (bottom row) staining on abdominal aorta sections from calcineurin control mice (left), mice conditionally lacking calcineurin in endothelial cells (middle), and mice conditionally lacking calcineurin in smooth muscle cells (right), with and without angiotensin-II treatment.

Calcineurin is a phosphatase implicated in AngII-induced abdominal aortic #aneurysm (AAA). This study reveals a novel, phosphatase-independent mechanism by which #Calcineurin contributes to AAA, dependent on transcriptional reprogramming of #SmoothMuscleCells @plosbiology.org 🧪 plos.io/4kfnT3L

Smooth muscle cell calcineurin is required for angiotensin-II-induced abdominal aortic aneurysm formation. Representative images of hematoxylin–eosin (top row), Masson trichrome (middle row), and Van Gieson (bottom row) staining on abdominal aorta sections from calcineurin control mice (left), mice conditionally lacking calcineurin in endothelial cells (middle), and mice conditionally lacking calcineurin in smooth muscle cells (right), with and without angiotensin-II treatment.

Calcineurin is a phosphatase implicated in AngII-induced abdominal aortic #aneurysm (AAA). This study reveals a novel, phosphatase-independent mechanism by which #Calcineurin contributes to AAA, dependent on transcriptional reprogramming of #SmoothMuscleCells @plosbiology.org 🧪 plos.io/4kfnT3L

Smooth muscle cell calcineurin is required for angiotensin-II-induced abdominal aortic aneurysm formation. Representative images of hematoxylin–eosin (top row), Masson trichrome (middle row), and Van Gieson (bottom row) staining on abdominal aorta sections from calcineurin control mice (left), mice conditionally lacking calcineurin in endothelial cells (middle), and mice conditionally lacking calcineurin in smooth muscle cells (right), with and without angiotensin-II treatment.

Calcineurin is a phosphatase implicated in AngII-induced abdominal aortic #aneurysm (AAA). This study reveals a novel, phosphatase-independent mechanism by which #Calcineurin contributes to AAA, dependent on transcriptional reprogramming of #SmoothMuscleCells @plosbiology.org 🧪 plos.io/4kfnT3L

“Indications and Long-Term Outcomes of Using Mycophenolate Mofetil Monotherapy in Substitution for Calcineurin Inhibitors in Liver Transplantation”

Read more here: www.frontierspartnerships.org/journals/tra...

#mycophenolate #therapy #calcineurin #inhibitor #longterm #outcome #liver #transplant

Calcineurin inhibitors promote chronic alloimmunity via propagation of central memory T cell subsets Calcineurin inhibitors (CNIs) are a cornerstone of immunosuppression following solid organ transplantation (SOT).1 Originally derived from the fungus Tolypocladium inflatum in the late 1970s, cyclospo...

#Calcineurin inhibitors promote chronic alloimmunity via propagation of central memory T cell subsets
www.amjtransplant.org/article/S160...

Our new paper describing an unexpected role of #calcineurin signaling in #RNAi-mediated small RNA production is now out in GENETICS - implying a way to quickly adapt to external conditions by altering gene expression levels. #Fungi #Cryptococcus
academic.oup.com/genetics/adv...