❓Did you know that...?

Covid can damage the endothelium, the inner layer of blood vessels, promoting circulatory problems and cardiac fatigue.

#LongCovidAwareness #LongCovidHeartBeats #Endothelium
#ApresJ20 @lcawarenessint.bsky.social

Assessment of seasonal variation in #cutaneous #microvasculature function in healthy adults shows lower #nitricoxide mediated cutaneous #vasodilation in winter/early-spring compared to summer/early-fall.

doi.org/10.14814/phy...
#Endothelium

Presentation

Poster session embl

Day 3 of #EMBLCardioBiology 2026 in Heidelberg with more outstanding talks such as the one on #endothelium in #adipose by Joanna Kalucka, a great poster session and a tour of the city to wrap it up!

Client Challenge

#Apresj20 #LongCovid #MECFS #EM #PostViral #Endothelium #MPE #Recherche

www.nature.com/articles/s41...

Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human - Nature Communications Deciphering body-brain communication pathways is key to a deeper understanding of brain physiology and pathology. Here, the authors define the astrocyte endfoot proteome and show dynamic vascular-to-a...

#astrocytes #endothelium #cerebrovascular 😱🤩🤩

Very proud of this work that is now out on JCI describing a new #signaling pathway downstream of the #cytokine IL-6 in the #endothelium with implications in #sepsis and #shock. Short thread with a summary coming later today.
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!

🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...

🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...

Soluble guanylyl cyclase, the NO receptor, drives vasorelaxation via endothelial S-nitrosation | PNAS We previously demonstrated that the NO-stimulated soluble guanylyl cyclase (GC1), which produces cGMP, also has the ability to transfer S-nitrosoth...

An important advance in vascular biology!! #endothelium #vascular

Dr. Liz Kiernan talks us through "Endothelium in Kidney Health and Disease," by reviewing #kidney vasculature #physiology and eGFR, structure and function of #endothelium, #pathophysiology and signaling, #biomarkers and #therapeutics. @uwmedicine.bsky.social #nephsky

Watch: youtu.be/b1Nr0QRcVeQ

Coronary microvascular disease in women: epidemiology, mechanisms, evaluation, and treatment Coronary microvascular dysfunction (CMD) involves functional or structural abnormalities of the coronary microvasculature resulting in dysregulation of coronary blood flow (CBF) in response to myocard...

#Coronary #microvascular #disease in #women:

Epidemiology, mechanisms, evaluation and treatment

#CMD #MVS #MVA 🫀
#Vasomotor #dysfunction
#Endothelium #dependent #independent
#CFR #IMR #MPRI
#ACh #provocation #testing
#INOCA #MINOCA #ANOCA #NOCAD

cdnsciencepub.com/doi/10.1139/...

CXCR3-CXCL11 signaling restricts angiogenesis and promotes pericyte recruitment Endothelial cell (EC)-pericyte interactions are known to remodel in response to hemodynamic forces, yet there is a lack of mechanistic understanding of the signaling pathways that underlie these event...

#Pericyte #Endothelium #Angiogenesis

The Role of Capillary Health in Long COVID Recovery Long COVID affects many individuals, with symptoms linked to microclots that hinder oxygen delivery. However, new research indicates vascular injuries, such as capillary rarefaction and endothelial…

Everyone’s chasing clots, but the real damage might be hiding in plain sight inside your capillaries.

Impaired perfusion, endothelial stress, mitochondrial fallout… all in vessels you need a microscope to see.

More on longcovidjourney.com/2025/07/23/t...

#LongCovid #Microvascular #Endothelium

Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling Vasodilatory signals are rapidly communicated across long distances by endothelial-endothelial gap junctions, enabling coordinated dilation of the arterial network during neurovascular coupling.

Very cool new paper by @thegulab.bsky.social published in Cell, showing that arterial endothelial coupling via gap junctions determines the speed and spread of vasodilation induced by neuronal activity ! #cerebrovascular #bloodflow #endothelium

🧠 “It’s anxiety.”
🩸 Meanwhile:
– Impaired flow
– Platelet chaos
– Endothelial distress

Long COVID isn’t in your head.
It’s in your vessels.

More on longcovidjourney.com

#LongCOVID #Microvascular #PASC #MedTwitter #microclot
#endothelium

Red blood cells drive blood vessel damage in diabetes by exporting toxic vesicles Red blood cell-derived extracellular vesicles in type 2 diabetes are actively taken up by the endothelium, transferring the enzyme arginase-1 and triggering oxidative stress. This mechanism helps expl...

Red blood cells drive blood vessel damage in diabetes by exporting toxic vesicles www.news-medical.net/news/2025051... #diabetes #vascularhealth #redbloodcells #oxidativestress #endothelium #cardiovascular #medical #biomarkers #therapeutics

Calciprotein particle-activated endothelial cells aggravate smooth muscle cell calcification via paracrine signalling - Cellular and Molecular Life Sciences Background Vascular calcification is highly prevalent in Chronic Kidney Disease (CKD) and is associated with markedly increased cardiovascular risk. High serum phosphate in CKD increases calcification...

Our latest collaborative effort to improve our knowledge
🔬 One name:
#Calciprotein particle
🧪 One pathway:
#Calcification and #secretome
🥇 The place:
From the #Endothelium to vascular #muscle

It's in Cellular and Molecular Life Sciences @springernature.com
link.springer.com/article/10.1...

ENDOTHELIAL-SPECIFIC KNOCKOUT OF THE SCRAMBLASE TMEM16F IMPAIRS IN VIVO CLOT FORMATION - PubMed Objective: Loss of function of the phospholipid scramblase (PLS) TMEM16F results in Scott syndrome, a hereditary bleeding disorder generally attributed to intrinsic platelet dysfunction. The role of T...

👀 New paper alert! @devdoot.bsky.social.

The #endothelial cell scramblase TMEM16f is critical for #hemostasis, independent of platelets. This explains bleeding in Scott's syndrome.

#ionchannels #endothelium #bloodvessel #hemostasis #NIGMS #NHLBI #scicomm

1/n

pubmed.ncbi.nlm.nih.gov/39874534/

Work performed at CRBS - Centre de recherche en biomédecine de Strasbourg @unistra.fr @inserm.fr
#zebrafish #metastasis #imaging #tumor #vascular #endothelium

Changes in endothelial cell large conductance calcium-activated potassium channels (BKCa) after #hypoxia may explain the altered myogenic tone which impacts blood flow following ischemic #stroke.

#ionchannels #vascularbiology #physiology #cerebrovascular #endothelium #neurosky #emedsky #medsky

How do endothelial cells in #liver become leaky, while those in #brain tissue form an impermeable barrier? Because transcriptional regulators drive endothelial cells towards organ-specific specialization.

#endothelium #bloodvessel #ImmunoSky#MedSky 🧪

🚨 Publication alert!🚨 Our new study (onlinelibrary.wiley.com/doi/full/10....) in Acta Physiologica shows that #stroke/#hypoxia induces the expression of BK-Ca channels in the #cerebrovascular #endothelium across species 🧔🏻‍♂️🐭🐷🐀. These channels, absent in normoxia, regulate post-stroke arterial tone.

Endothelial integrin acetylation regulates vascular barrier function. This suggests new therapeutic possibilities for controlling vascular permeability in disease states.

#Endothelium #VascularBiology #ImmunoSky #MedSky 🧪

Activity and function of the endothelial sodium channel is regulated by the effector domain of MARCKS-like protein 1 in mouse aortic endothelial cells | American Journal of Physiology-Cell Physiology ... Enhanced endothelial sodium channel (EnNaC) functioning causes an increase in vessel stiffness. Here, we investigated the regulation of EnNaC in mouse aortic endothelial cells (mAoECs) by the actin cy...

Amiloride-sensitive sodium channels in vascular endothelial cells are regulated by the PIP2 / lipid rafts and act to increase aortic stiffness.

journals.physiology.org/doi/full/10....

#NIH #ionchannels #endothelium #bloodvessel #MedSky 🧪

Joanna on vasculopathies and endothelial cells

Magda on surprising endothelial to mesothelioma transitions

Jakob on the smooth muscle cells in the wall of vessels with atherosclerosis

Anita and the axolotl heart - the influence of the extracellular matrix

With talks on ❤️ #atherosclerosis, #endothelium #retina #cerebral #capillaries in humans, 🐦, 🦎, axolotls, 🐀

🚨 🆕 NIH-funded 🔬 byYu et al reveal how MARCKS-like protein 1 (MLP1) modifies endothelial sodium channel (EnNaC) activity🧬-Phosphorylation of MLP1 decreases EnNaC function👉 journals.physiology.org/doi/abs/10.1...
#IonChannels #Endothelium #Physiology #Science #NIH 🧪

Exploring Endothelial Cell Dysfunction’s Impact on the Brain-Retina Microenvironment Connection: Molecular Mechanisms and Implications - Molecular Neurobiology The intricate linking between the health of blood vessels and the functioning of neurons has attracted growing attention in the context of disorders that affect the neurological environment. Endotheli...

New review exploring bidirectional communication between the brain and the retina #Brain #Endothelium

This work builds on our earlier work and validates the strong and active contribution of the #endothelium to key steps of metastasis...