Calciprotein particle-activated endothelial cells aggravate smooth muscle cell calcification via paracrine signalling - Cellular and Molecular Life Sciences Background Vascular calcification is highly prevalent in Chronic Kidney Disease (CKD) and is associated with markedly increased cardiovascular risk. High serum phosphate in CKD increases calcification...

Our latest collaborative effort to improve our knowledge
🔬 One name:
#Calciprotein particle
🧪 One pathway:
#Calcification and #secretome
🥇 The place:
From the #Endothelium to vascular #muscle

It's in Cellular and Molecular Life Sciences @springernature.com
link.springer.com/article/10.1...

Calciprotein particle‐induced calcium overload triggers mitochondrial dysfunction in endothelial cells Abstract figure legend Calciprotein particles (CPPs) are small calcium- and phosphate-containing nanoaggregates associated with the development of vascular disease (CVD) in chronic kidney disease (CK....

I am thrilled to have participated in this fruitful collaboration which has just been published ... new discovery linking #nanoparticle, #mitochondria and #calcium ! #calcification #cardiovascular disease #hypercalcemia #kidney #calciprotein physoc.onlinelibrary.wiley.com/doi/10.1113/...