New organoids offer deeper insights into pediatric brain cancer Researchers from the University of Trento, in collaboration with Bambino Gesù Children's Hospital in Rome, are using biopsy-derived organoids to search for new drugs.

Patient-derived #organoids (PDOs), or tumoroids, for pediatric #braincancer show promise in helping researchers find new drugs and better understand the different responses of #ependymoma and #medulloblastoma tumors.

Metabolic vulnerability in fusion-driven ependymoma - Nature Reviews Cancer In a recent study published in Nature, Natarajan et al. uncover a metabolic–epigenetic circuit in which glutamine-derived itaconate functions as an oncometabolite to sustain oncogenic ZFTA–RELA expression in ependymoma. Disrupting this pathway lowers ZFTA–RELA levels and suppresses tumour growth in preclinical models, revealing a promising therapeutic vulnerability in this aggressive cancer.

#ResearchHighlight
In a recent study published in Nature, Natarajan et al. uncover a metabolic–epigenetic circuit in which glutamine-derived itaconate functions as an #oncometabolite to sustain oncogenic ZFTA–RELA expression in #ependymoma.
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ZR fusion protein sways normal brain cell development toward cancer growth A team of researchers at Baylor College of Medicine, St. Jude Children’s Research Hospital, Texas Children’s Hospital and collaborating institutions...

Team at @bcmhouston.bsky.social, @stjuderesearch.bsky.social et al reveals driver of the third most common pediatric #brainTumor. #ependymoma B Deneen, @alishakardian.bsky.social S. Mack @bcmneurosurgery.bsky.social #BCMGradSchool #BCMCancerCenter #TexasChildrens www.bcm.edu/news/zr-fusi...

Epigenetic News – Ependymoma fusion protein locks cells in developmental limbo

News - bit.ly/4c6cL7q Nature - go.nature.com/3NWYnVQ

alishakardian.bsky.social /Hua Sun & and Kelsey Bertrand/Benjamin Deneen/Stephen C. Mack

#Epigenetics #Ependymoma
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Gain deeper insight; epigenometech.com

We’re proud to announce a new NBTS-funded research project through the CERN Foundation to advance understanding of spinal #ependymoma — a rare and understudied CNS tumor affecting children & adults.

Learn more: https://bit.ly/4sbGL72

Australian trial of personalised vaccines to treat children with deadly brain cancers A world-first clinical trial will test cancer vaccines designed specifically for children with advanced or treatment-resistant brain tumours, following a $2.578 million investment from the Australian ...

Australian trial of personalised vaccines to treat children with deadly brain cancers. news.uq.edu.au/2026-02-aust...

#Cancer #Brain #Paediatric #Pediatric #Australia #Medulloblastoma #Ependymoma #Glioma #Oncology #mRNA #Genome #Genetics #DNA #AcademicSky #AcademicChatter #ClinicalTrial #Vaccine

Are you a patient or caregiver impacted by #acousticneuroma, #ependymoma, #medulloblastoma, or #primaryCNSlymphoma?

We’d love to hear from you in the comments and amplify the unique challenges and experiences that came with your #braintumor diagnosis: https://bit.ly/4azxmjF

Epigenetics Update - ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression go.nature.com/49Ydk2b

Sriram Venneti (University of Michigan) reporting in Nature

#Epigenetics #Ependymoma #Itaconate
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Discover the breakthrough at epigenometech.com

Proud to support early-career talent: Dr. Siri Ippagunta (Mack Lab, St. Jude Children’s Research Hospital) is the 2026 CERN & Robert Connor Dawes Fellow.

Together, we’re building momentum against #ependymoma.

Learn more: https://bit.ly/4aaQ27U

Congrats Daniel Heller and team on another potential game changer in the field of drug delivery!!!!
These nanoPROTACs get even more exciting in the brain space for CNS disorders! Stay tuned!
#medulloblastoma #DMG #DIPG #GBM #Ependymoma #SelectinTherapeutics
#EndPediatricBrainCancer

Developing an advanced risk stratification model for pediatric intracranial ependymoma based on the prospective trial E-HIT2000 and subsequent registries AbstractBackground. Current treatment strategies for pediatric intracranial ependymoma do not consider molecular heterogeneity. Here, we evaluated molecula

Our study presenting the results of the E-HIT2000 trial and a new clinical-molecular stratification model for paediatric #ependymoma is finally online in Neuro-Oncology! 🎉 1/3

share.google/6h9yoFqhaFtQ...

Two-year-old Kevin was diagnosed with an #ependymoma after experiencing sudden and severe symptoms.

With strong community support and treatment, Kevin is now four years cancer-free. braintumor.org/news/pediatric-ependymom...

#GoldforCCAM #CCAM

We are heartbroken to share that Kai, whose love for music inspired us all, has passed away at 12 from #ependymoma.

This Childhood Cancer Awareness Month, we honor his remarkable life.

Read Kai’s story: braintumor.org/news/notes-of-courage-ka...

#GoldforCCAM #CCAM

Join us and the CERN Foundation tomorrow, June 10, on International Ependymoma Awareness Day for a webinar at 12 p.m. (noon) ET.

Register now to hear stories from #ependymoma survivors, learn from experts, & participate in community polls: braintumor.org/research/ini...

As you heard from Liz & Julio, finding community can make all the difference while navigating an #ependymoma diagnosis.

Join us for the International Ependymoma Awareness Day webinar on June 10, 2025, at noon ET: braintumor.org/research/ini...

Antonia Gocke representing our group at #SNOPeds2025 !

She shows our data on LIN28A in atypical teratoid rhabdoid tumors and proteome data on a large cohort of #ependymoma. Fantastic job Antonia!
#atrt #braintumor #pediatriccancer #kinderkrebs #proteomics #neurooncology #Neuropathology #zmnh

The ITCC Scientific Days in Newcastle have been a great meeting - thank you to the organisers! It was a pleasure to contribute to the excellent programme by presening our latest approach to #ependymoma stratification! #cancer #neurooncology

Living beyond diagnosis: Angela’s 30-year journey with ependymoma cancer! #TCSC #ependymoma #cancertreatment #cancer #cancercare

newsnetwork.mayoclinic.org/discussion/l...

The Center of Excellence in Neuro-Oncology Sciences at St Jude uses innovative strategies to advance knowledge, enhance treatment, and improve outcomes for children affected by #braincancer, including #medulloblastoma #ependymoma #glioma.