OICR Drug Discovery is teaming up with Dr. Sheila Singh at McMaster University to develop a potentially game-changing treatment option for the most aggressive form of #medulloblastoma. This research could offer less toxic treatment to stop deadly childhood #braincancer https://bit.ly/4tGQL90

New organoids offer deeper insights into pediatric brain cancer Researchers from the University of Trento, in collaboration with Bambino Gesù Children's Hospital in Rome, are using biopsy-derived organoids to search for new drugs.

Patient-derived #organoids (PDOs), or tumoroids, for pediatric #braincancer show promise in helping researchers find new drugs and better understand the different responses of #ependymoma and #medulloblastoma tumors.

✅️ Recognize key histologic and immunohistochemical features supporting diagnosis
✅️ Identify evidence-based systemic therapy strategies across pediatric and adult medulloblastoma

#Medulloblastoma #NeuroOncology #Oncology #OncoIQ #MedicalEducation #CancerCare #OncologyTraining #CancerEducation

Advocacy works! After helping pass two pediatric bills, the Rubensteins are pushing for the #BRAINAct to improve survivorship care.

Get inspired by Libby’s story and join us at #Head2Hill this May to make your voice heard: https://bit.ly/4kWBr50

#medulloblastoma

Posterior Fossa Syndrome Linked to Long-Term Neurocognitive Deficits in Medulloblastoma Survivors Investigators evaluated the long-term neurological, neurocognitive, social, and quality of life outcomes associated with posterior fossa syndrome among survivors of medulloblastoma.

Survivors of childhood #medulloblastoma who also had a history of posterior fossa syndrome experienced long-term neurocognitive and physical impairments. Published in @jamanetworkopen.com.

https://bit.ly/4bhJxlE

#PediatricCancer

Australian trial of personalised vaccines to treat children with deadly brain cancers A world-first clinical trial will test cancer vaccines designed specifically for children with advanced or treatment-resistant brain tumours, following a $2.578 million investment from the Australian ...

Australian trial of personalised vaccines to treat children with deadly brain cancers. news.uq.edu.au/2026-02-aust...

#Cancer #Brain #Paediatric #Pediatric #Australia #Medulloblastoma #Ependymoma #Glioma #Oncology #mRNA #Genome #Genetics #DNA #AcademicSky #AcademicChatter #ClinicalTrial #Vaccine

Confocal images of Drosophila wing imaginal discs showing the effects of cohesin and PARP depletion. Panels display GFP‑marked regions of the wing pouch with staining for DNA (DAPI), DNA‑damage foci (γH2Av), and apoptosis (cleaved Caspase‑3). Quantification plots show increased γH2Av‑positive and cCas3‑positive cells in specific depletion conditions, with statistical comparisons indicating significant elevations in DNA damage and apoptosis relative to controls.

Simona Totaro, Valentina Massa, @vaccarilab.bsky.social & co showed that somatic STAG2 variants occur in #glioblastoma and #medulloblastoma, and that reducing SA1 during fly brain development disrupts neural stem cell differentiation and drives tumorigenesis.

Read doi.org/10.1242/dmm....

Four graphs show cumulative incidence over time in years, comparing "Yes" and "No" groups. The graphs are titled: A) Incidence for cerebellar dysfunction, B) Incidence for cranial nerve disorder, C) Incidence for peripheral motor neuropathy, D) Incidence for peripheral sensory neuropathy.

#PosteriorFossaSyndrome in survivors of #Medulloblastoma was associated with lasting neurocognitive and physical impairments, highlighting the need for ongoing support and interventions in long-term survivorship.

ja.ma/4b0Dvpm

Are you a patient or caregiver impacted by #acousticneuroma, #ependymoma, #medulloblastoma, or #primaryCNSlymphoma?

We’d love to hear from you in the comments and amplify the unique challenges and experiences that came with your #braintumor diagnosis: https://bit.ly/4azxmjF

Epigenetics Update - Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma bit.ly/49AgeZu

#Epigenetics #Multiomics #Medulloblastoma
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Discover the breakthrough at epigenometech.com

That’s me telling our story for The Kids Cancer Project.
Fred is a 10yr survivor of #medulloblastoma and we have participated in a number of research studies funded by TKCP I hate that we need charities to do this work but am thankful for everything they do youtu.be/HzdRCm9fRgE

Kids with brain cancer were already in a life and death struggle. Then came Trump The US president vowed to ‘end childhood cancer’. But his administration is dismantling the search for a cure and sending families scrambling for treatment

#ChildhoodCancer advocates-
This is a powerful piece on the negative impact of Trump administration policies on children with brain cancer, written by a spouse who lived this horror.

#DMG/DIPG
#ETMR
#Medulloblastoma
#PEDCAN

www.theguardian.com/us-news/ng-i...

Congrats Daniel Heller and team on another potential game changer in the field of drug delivery!!!!
These nanoPROTACs get even more exciting in the brain space for CNS disorders! Stay tuned!
#medulloblastoma #DMG #DIPG #GBM #Ependymoma #SelectinTherapeutics
#EndPediatricBrainCancer

News/Opinion: ISABELLA STRAHAN SHVASHIANS WHAT IT’S LIKE TO RETURN TO COLLEGE LIFE AFTER CANCER TREATMENT. Isabella Strahan’s Journey Back to College Life: A Personal ReflectionThe journey back to college life after cancer treatment is one of profound reflection and resilience. Isabella Strahan, a 21-year-old student reflecting on her return, shares how it has rejuvenated her spirit and brought hope into an otherwise challenging time. As the link provided highlights, she’s taken significant steps toward rebuilding her life, showcasing both joy and a renewed sense of purpose.Joy and Resilience in TransitionThe first paragraph sets the scene, acknowledging that cancer has deeply impacted Isabella’s life. She chose to return to college with the strength of hope, recognizing that it was an opportunity to rekindle her passion for learning and community. The transition back from her oncology treatment home to campus has been a humbling yet transformative experience.Support from Friends and FamilyIsabella’s immediate comfort came from strong support systems within her community. Her friends and family have provided emotional and mental comfort, helping her navigate the emotional rollercoaster of cancer treatment. This support not only uplifted Isabella but also reinforced her commitment to college life, emphasizing the importance of resilience in rebuilding her identity.Transitioning Back to CampusThe second section delves into her transition back to campus, highlighting both the physical and mental adjustments. Despite challenges like moving back into a new home, she found her voice and energy. Social interactions expanded beyond the classroom, leading to deeper connections with peers and faculty, fostering a sense of belonging.Financial Challenges and AdaptationThe article also touches on the financial pressures that came with cancer treatment, particularly for students. Isabella’s ability to adapt has been key, allowing her to balance her studies with personal responsibilities. This experience has taught her valuable lessons about resilience and the importance of planning for the future.Overall Impact and HopeIn reflecting on the past year, Isabella embodies a testament to hope amidst challenges. She sees cancer treatment as an opportunity to face new life with greater perspective. Her story serves as a reminder that cancer doesn’t define one’s identity but can instead redefine it by teaching resilience and adaptability in the face of adversity.As she moves forward, Isabella looks forward to continuing her journey of learning and embracing college life, knowing that each step is an opportunity to grow and find meaning in their purpose. The world continues to heal, much like Isabella’s journey, showing that healing takes time but also finds beauty in the effort itself.------#NEWS #F.A.S.T.Haircare #IsabellaStrahan #medulloblastoma #MichaelStrahan #USC

News/Opinion: ISABELLA STRAHAN SHVASHIANS WHAT IT’S LIKE TO RETURN TO COLLEGE LIFE AFTER CANCER TREATMENT.: Isabella Strahan’s Journey Back to College Life: A Personal ReflectionThe journey back to college life after cancer treatment is one… #SummerWalker #NEWS #F #IsabellaStrahan #medulloblastoma

Data-Driven Risk Stratification Guides Childhood Brain Tumor Treatment, Reducing Side Effects | Newswise Scientists at St. Jude analyzed medulloblastoma data to better understand treatment needs, lowering treatment intensity and toxicity and sharing the approach in an online portal.

Data-Driven Risk Stratification Guides Childhood Brain Tumor Treatment, Reducing Side Effects
www.newswise.com/articles/dat...
#medulloblastoma #treatmenttoxicities #treatmentintensity #NeuroOncology

Data-driven risk stratification guides childhood brain tumor treatment, reducing side effects Find how St. Jude researchers discovered a new way to group patients with medulloblastoma, which could lead to major reduction in treatment-related toxicity.

Scientists at St. Jude published the largest analysis of #medulloblastoma treatment from ~900 patients. By harmonizing clinical & molecular data, they identified new risk groups—enabling more precise, less toxic therapies for kids. ow.ly/XtYs50Xn8cF 🧠✨

🎉🎉
I couldn’t be prouder of my amazing former supervisor. I’m really looking forward to collaborating with you again on this exciting project!

#medulloblastoma #metabolism

Cross‑Platform DNA Methylation Classifier for Medulloblastoma Subtypes

Classifier identifies all eight Group 3/4 medulloblastoma subtypes on Illumina HM450 and EPIC arrays, achieving a weighted F1‑score of 0.95. Read more: getnews.me/cross-platform-dna-methy... #medulloblastoma #dnamethylation

News/Opinion: Isabella Strahans has always loved life, yet cancer at first seemed like a burden. It made the path to a more fulfilling life feel like an uphill battle she couldn’t easily overcome. Yet, it also offered her a sense of meaning—perhaps even some solace—and an opportunity for a deeper understanding of what truly makes life meaningful. Through this journey, she has learned that cancer isn’t just a diagnosis but a lesson in resilience and perseverance. Isabella Strahana: Embracing Cancer as A Journey Rather Than A LabelIn an interview shared online earlier, Isabella Strahana, the 20-year-old daughter of a former NFL star, opened up about her experience with cancer. The simple act of running down a trail or laughing with friends feels like a victory, she stated, capturing her perspective as one where resilience and peace are paramount. This quote encapsulates her journey, one that transcends the stigma of cancer by offering a positive outlook.Background and Early LifeIsabellas life began in her hometown of Los Angeles, a place she cherished throughout her childhood. From sports to volunteering, she found fulfillment in her past endeavors. However, as her body developed cancer, it wasnt just one more disease; it became an unavoidable part of her identity. She recalled, I felt like I was walking on eggshells at times, vividly illustrating the emotional toll.Pride in Her JourneyDespite the journey, Isabella remained proud of her transformation. When she shared her story with others, especially those who were cancer survivors, it brought strength. She emphasized that the cancer isnt a label but a part of who she is. Its okay to laugh with people I never knew before, she admitted, reiterating resilience.Achievements and TransformationsIsabellas transformation was marked by her involvement in cancer awareness campaigns. She led efforts for the American Cancer Society, advocating for accessible resources. This not only supported her own health but also inspired others. Her participation in NFL training further enriched her life, showing how cancer doesnt limit opportunities.Challenges and ResilienceThough journey-oriented, Isabella faced challenges. She learned that perseverance is key. Its hard when you have to face what you dont want, she mentioned, expressing determination in finding strength. Her support system, including friends and family, played a crucial role, offering both encouragement and reassurance.Future optimismIsabellas future is bright, with the promise of new adventures. She appreciates the time she has spent with those who now face cancer—showing that hope extends beyond cancer. Finding peace without labels like cancer warrior feels so much more real, she stressed, highlighting resilience and strength.Emotional SupportBeyond her own journey, Isabella found emotional support from others. Her friends and family were there to offer encouragement, acknowledging the weight of cancer but valuing their help. This provided a sense of purpose in an otherwise overwhelming time.In conclusion, Isabella Strahanas story underscores that cancer isnt a fixed entity but a part of life. It teaches resilience, finding strength, and embracing ones journey. As she faces new challenges, she remains hopeful, knowing she has support and strength to overcome. Her message is one of unwavering hope and found beauty in her battles.------#NEWS #IsabellaStrahan #medulloblastoma #MichaelStrahan

News/Opinion: Isabella Strahans has always loved life, yet cancer at first seemed like a burden. It made the path to a more fulfilling life feel like an uphill battle she couldn’t easily overcome. Yet, it also offered her a sense of… #HBCU #NEWS #IsabellaStrahan #medulloblastoma #MichaelStrahan

Please reach out if you'd like to learn more or help us amplify this important resource for patients and their care teams.

#cancerresearch #clinicaltrials #cancer #braincancer #GBM #gliomas #meningioma #medulloblastoma

📣 Don't miss our new Commentary

Only the strong survive: therapeutic selective pressure drives medulloblastoma leptomeningeal metastasis

🖊️ @MSKCancerCenter @adrienne_boire

#Leptomeningeal #Metastasis #Medulloblastoma

Image from article in Radiology: Artificial Intelligence

#ThrowbackThursday – Two automated nn-Unet-based models for segmentation of pediatric #medulloblastoma tumors demonstrated high performance & agreement with expert neuroradiologists (Sep 2024) https://doi.org/10.1148/ryai.230115 #AI #ML #Radiomics

🚨New work from the #NUCancer Paediatric Brain Tumour Group shows not all MYC/MYCN-amplified medulloblastomas are the same.

🔹 Some patients face near-incurable disease & need new therapies
🔹 Others can survive long-term with current treatment

#ChildhoodCancer #Medulloblastoma

Medulloblastoma Welcome to our brand new website MEDULLABLASTOMA

medulloblastoma.webnode.page/
#MEDULLOBLASTOMA
#BRAIN
#CANCER

Study in mice finds drug that could improve childhood brain cancer treatment Researchers in Canada have discovered why a group of childhood brain cancers are resistant to radiation therapy in a study using mice.

Researchers at the Hospital for Sick Children
@sickkidsto.bsky.social & EARA member University of Toronto
@utoronto.ca have discovered why a group of childhood #brain cancers are resistant to radiation therapy in a study using #mice. #AnimalResearch #medulloblastoma

🔗 www.eara.eu/post/study-i...

Genome-wide cfDNA fragmentation patterns in cerebrospinal fluid reflect medulloblastoma groups - npj Precision Oncology npj Precision Oncology - Genome-wide cfDNA fragmentation patterns in cerebrospinal fluid reflect medulloblastoma groups

Excited to share our new paper: "Genome-wide cfDNA fragmentation patterns in cerebrospinal fluid reflect medulloblastoma groups."

nature.com/articles/s41...

#Medulloblastoma #Fragmentomics #LiquidBiopsy #cfDNA #CerebrospinalFluid

This #NationalScienceWeek we're celebrating the future leaders of childhood cancer research - our Future Leader Fellows who are advancing research in the hardest-to-treat childhood cancers. #ScienceWeek #medulloblastoma #braincancer @monashuniversity.bsky.social @hudsonresearch.bsky.social

The St. Baldrick’s Foundation has awarded Seattle Children’s Rebecca Ronsley MD, FRCPC, a $330k Scholar Grant to support the development of an innovative clinical trial evaluating a potential therapy for pediatric #medulloblastoma.

After surgery following a #medulloblastoma diagnosis at 25, Gavin developed #posteriorfossasyndrome, which left him nonverbal for six weeks and required rehabilitation that is still ongoing.

Read his story and learn about the progress he's making: braintumor.org/news/the-sur...

🏆 #NUCancer Conference 2025: Prize Winner Spotlight

Congratulations to Louisa Taylor, PhD, winner of a Flash Talk Award for her cutting-edge work on high-risk MYC-amplified #medulloblastoma. 🔬💡

#childhoodcancer #childhoodcancerawareness #pediatriccancer #cancerresearch