Fast execution - 5 mins runtime for 200 samples using combined segmentation (versus 40 mins runtime for established algorithms conumee and conumee 2)

#DNAmethylation #EPICv2 #bioinformatics #braintumor #neurooncology #neuropathology #ukeHamburg #zmnh #diagnostics

High performance data integration for large-scale analyses of incomplete Omic profiles using Batch-Effect Reduction Trees (BERT) - Nature Communications This study presents BERT, an algorithm for high-performance integration of incomplete omics data with robustness to unequal phenotype distribution. It validates the method on simulated and experimenta...

** High performance #dataintegration for large-scale analyses of incomplete Omic profiles **
Meet BERT (our new algorithm Batch-Effect Reduction Trees) - details in #naturecommunications :
www.nature.com/articles/s41...
#transcriptomics #proteomics #metabolomics #dataanalysis #zmnh #ukeHamburg

Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes - Acta Neuropathologica Communications Atypical teratoid rhabdoid tumors (ATRTs) are aggressive central nervous system tumors mainly affecting young children. Extensive molecular characterization based on gene expression and DNA methylatio...

I** Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes **
Now out in Acta Neuropathol Commun: actaneurocomms.biomedcentral.com/articles/10....
Special thanks to the Roggenbuck Foundation for funding!
#Neurooncology #Neuropathology #zmnh #ukeHamburg

Jelenas work on #spatialproteomics of the developing brain has now been published in Molecular md Cellular Proteomics (www.mcponline.org/article/S153... )

#neurooncology #neurodevelopment #proteomics #Neuropathology #zmnh #ukeHamburg

Antonia Gocke representing our group at #SNOPeds2025 !

She shows our data on LIN28A in atypical teratoid rhabdoid tumors and proteome data on a large cohort of #ependymoma. Fantastic job Antonia!
#atrt #braintumor #pediatriccancer #kinderkrebs #proteomics #neurooncology #Neuropathology #zmnh

Dear Jelena, now you successfully defended your PhD ‐ congratulations! We are very happy to have you in the team!

#proteomics #etmr #spatialproteomics #zmnh #ukeHamburg #neurooncology #neurodevelopment #neuropathology