Metabolic vulnerability in fusion-driven ependymoma - Nature Reviews Cancer In a recent study published in Nature, Natarajan et al. uncover a metabolic–epigenetic circuit in which glutamine-derived itaconate functions as an oncometabolite to sustain oncogenic ZFTA–RELA expression in ependymoma. Disrupting this pathway lowers ZFTA–RELA levels and suppresses tumour growth in preclinical models, revealing a promising therapeutic vulnerability in this aggressive cancer.

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In a recent study published in Nature, Natarajan et al. uncover a metabolic–epigenetic circuit in which glutamine-derived itaconate functions as an #oncometabolite to sustain oncogenic ZFTA–RELA expression in #ependymoma.
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Cancer Causing Bacteria Research shows gut microbiota is associated with various types of cancer. One example of cancer causing bacteria is Fusobacterium Nacleatum.

"Cancer causing Bacteria"

Please read this important article.

www.linkedin.com/pulse/cancer...

#research #science #cancer #bacteria #fusobacterium #promotion #nationalgeographic #oncometabolite #colorectalcancer #colorectal #gut #mit #ucla #patients #formate #metabolism #signal #metastasis

New alleles of D-2-hydroxyglutarate dehydrogenase enable studies of oncometabolite function in Drosophila melanogaster Abstract. D-2-hydroxyglutarate (D-2HG) is a potent oncometabolite capable of disrupting chromatin architecture, altering metabolism, and promoting cellular

Check out our work in @genetics-gsa.bsky.social #G3journal on new #Drosophila tools for studying D-2HG #oncometabolite in a context dependent manner during development and disease.
#devbio #genetics #metabolism

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@superflymr.bsky.social
@iubiology.bsky.social