Circular RNA circHomer1 mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs | Science Advances www.science.org/doi/10.1126/...
#circRNAs #circHomer1 #plasticity #neuroscience #RNAgranules #synaptic #mRNA #circularRNA
This review highlights coding #circRNAs in human #cancer, detailing IRES‑ and m6A‑mediated translation, circRNA‑encoded proteins regulating #tumor growth, #DrugResistance, and #metastasis, and their therapeutic potential with future challenges.
#OpenAccess: doi.org/10.1016/j.ge...
New year and new opportunities! There is an open call for a PhD student to join our lab.
#RNA biology #circRNAs #miRNAs #neuroscience #neuroedocrinology
Please share with potential candidates 🙏🫶.
A link to the call & more details here: www.phdscanner.com/opportunitie...
Direct circRNA-mRNA Binding Controls mRNA Fate "...novel & potentially transform. mech. of action: the direct interaction of #circRNAs w/mRNAs to regulate their fate. ...can influence mRNA stability & translation, ...new layer of post-transcriptional gene regulation." #circRNA
www.mdpi.com/3408568
An overview on the pathophysiological role of #circRNAs in #HBV-induced #HCC, their potential therapeutic applications, with insights into the challenges that limit their applications in HBV-induced HCC. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
"Results of the study, published in the journal npj Viruses, marks the first experimental evidence of HIV-1 generating #circRNAs produced from an integrated retroviral genome, offering a new perspective on HIV biology."
#aging #cancer #retroviruses #viruses
www.sciencedaily.com/releases/202...
"Emerging evidence indicates that circRNAs play pivotal regulatory roles in the aging process."
CircAge encompasses 803 aging-related samples from 7 species and 24 tissue types.
CircAge is publicly available at circage.kiz.ac.cn.
#aging #circRNAs
academic.oup.com/gpb/advance-...
📚 New Review to start the week!
The role of circular RNAs in regulating cytokine signaling in cancer
🔓 buff.ly/qTn5kDl
#circRNAs #Cytokines #CancerResearch
Expanded insights into the mechanisms of RNA-binding protein regulation of circRNA generation and function in cancer biology and therapy
A review of the role of RBPs in the synthesis & function of #circRNAs, the biological significance & regulation of circRNA-RBP interactions, their role in #tumorigenesis, and the potential of RBPs & circRNAs as therapeutic targets in #cancer treatment. #medsky
#OpenAccess: buff.ly/Q7uXsgS
Want to find out the full sequence of your #circRNAs to understand their function and variants? Check out our protocol to sequence entire circRNAs using ONT. Great coop. with C. Bessière, C. Gaspin, F. Meggetto, funded by @dfg.de, INCA, Assoc. Eva pour la vie.
link.springer.com/protocol/10....
Diagram comparing WT and OE-circZmMED16 mutant corn and Arabidopsis plants to illustrate how CircZmMED16, a circular RNA derived from the maize Pol II mediator complex 16 transcript, binds to the mRNA encoding a subunit of ADP-glucose pyrophosphorylase, resulting in reduced enzyme activity and impaired conversion of sucrose to starch, thereby delaying flowering time.
The functional and regulatory roles of #circRNAs in #PlantDevelopment are poorly understood. In a new JIPB article, Tang et al. reveal a novel regulatory mechanism involved in controlling #flowering time in #maize 🌽 .
doi.org/10.1111/jipb...
#PlantScience
