Graphical abstract of the original paper, source: orig. paper

🧬 The group of Dr. Vaněk have, for the first time, mapped all the sugar structures (#glycans) on #NKp46, a key #immune receptor. Both N- and O-glycans are crucial for recognizing a #yeast called Candida glabrata, which can cause serious infections in vulnerable patients. 🔽

🔗 buff.ly/UZjgq2g
(MK)

Representative CD20 staining of spleen and mandibular lymph node sections from animals treated with vehicle or CD20-NKCE-IL2v (0.5 mg/kg). Scale bars: 3 mm

This week in #ScienceImmunology: Olivier Demaria, Eric Vivier, & al. use tetraspecific #NKCell engager (comprising an anti- #NKp46 Ab fragment + #IgG1 #Fc fragment + #IL2 variant + anti- #CD20 Ab) to target #BCell -specific #NonHodgkin #lymphoma (B-NHL) in mouse & NHP models!

bit.ly/SI_adp3720