Meet A-Evolve: The PyTorch Moment For Agentic AI Systems Replacing Manual Tuning With Automated State Mutation And Self-Correction A team of researchers associated with Amazon has released A-Evolve, a universal infrastructure designed to automate the development of autonomous AI agents. The framework aims to replace the ‘manual harness engineering’ that currently defines agent development with a systematic, automated evolution process. The project is being described as a potential ‘PyTorch moment’ for agentic AI. Just as PyTorch moved deep learning away from manual gradient calculations, A-Evolve seeks to move agent design away from hand-tuned prompts and toward a scalable framework where agents improve their own code and logic through iterative cycles. The Problem: The Manual Tuning Bottleneck In current workflows, software and AI engineers building autonomous agents often find themselves in a loop of manual trial and error. When an agent fails a task—such as resolving a GitHub issue on SWE-bench—the developer must manually inspect logs, identify the logic failure, and then rewrite the prompt or add a new tool. A-Evolve is built to automate this loop. The framework’s core premise is that an agent can be treated as a collection of mutable artifacts that evolve based on structured feedback from their environment. This can transform a basic ‘seed’ agent into a high-performing one with ‘zero human intervention,‘ a...

Meet A-Evolve: The PyTorch Moment For Agentic AI Systems Replacing Manual Tuning With Automated State Mutation And Self-Correction
->MarkTechPost | More on "Automated AI agent development framework" at BigEarthData.ai | #Mutation #BirdFlu #AI

New COVID Strain With 75 Mutations Triggers Panic After 22 Countries Report Sudden Surge
->YouTube | More on "New COVID strain global spread" at BigEarthData.ai | #Covid #Mutation #BirdFlu

Mapping cis -regulatory mutations at scale in sorghum enables modulation of gene expression To understand how to improve photosynthetic gene expression using precise, small CRISPR-type edits (Fig. 1a), we developed an MPRA in sorghum protoplasts to identify hypermorphic and hypomorphic mutations within crDNA (Fig. 1b). Briefly, tens of millions of healthy mesophyll protoplasts were isolated from partially etiolated Sorghum bicolor cv. RTx430 seedlings (Extended Data Fig. 1 and Methods) and transfected with plasmid libraries containing crDNA variants. After an 18-h incubation in darkness, cells were exposed to 4 h of light to stimulate photosynthetic gene expression. Next, barcoded mRNA was harvested, next-generation sequencing was used to quantify barcodes in the input DNA and output RNA and linear regression was performed to infer individual variant effects, Emut (Methods and Extended Data Fig. 2). In contrast to prior work15,16,17, we focused our efforts on the natural, 2-kb 5′ promoter and the 5′ UTR in the context of the full gene content, to account for possible dependencies of mutation effects on the intron and 3′ UTR sequences (Fig. 1c). Each crDNA library was expressed on a plasmid upstream of the relevant gene sequence with all introns followed by 1 kb of genomic sequence downstream of the stop codon. For each library, a 15-bp DNA barcode was...

Mapping cis -regulatory mutations at scale in sorghum enables modulation of gene expression
->Nature | More on "Sorghum gene expression cis-regulatory mapping" at BigEarthData.ai | #BirdFlu #Mutation

Two models for the nature of pleiotropy in adaptation. Left: Schematic of the environmental structure in this study. Environments can be mapped onto a multidimensional environment space characterized by chemical and physical compositions. The large green circle represents an environment where adaptive mutants evolved, and the large pink circle is a distant environment. Around each base, a set of identical environmental perturbations (arrows) is applied, generating clusters of similar environments around distinct base environments. Top right: Schematic of fitnotype map for adaptive mutants near their home base environment. By measuring fitness in each of the green environments, one can infer how many fitnotypes matter for this set of mutants in their home environment. Here, only four of the possible 8 fitnotypes matter. Bottom right: When the mutants are moved to the distant base environment, and their fitness is measured in all pink environments (base and perturbations), there are two possibilities. Either more fitnotypes become important and the space appears higher-dimensional (left, pleiotropic expansion), or the set of fitnotypes that matters remains low-dimensional, but shifts (right, pleiotropic shift).

Predicting the effect of a #mutation on #fitness is hard. @oliviamghosh.bsky.social @petrovadmitri.bsky.social &co use fitness effects of adaptive yeast mutants to show that underlying genotype-phenotype-fitness maps are low-dimensional but context-dependent @plosbiology.org 🧪 plos.io/4dLy2Ez

Two models for the nature of pleiotropy in adaptation. Left: Schematic of the environmental structure in this study. Environments can be mapped onto a multidimensional environment space characterized by chemical and physical compositions. The large green circle represents an environment where adaptive mutants evolved, and the large pink circle is a distant environment. Around each base, a set of identical environmental perturbations (arrows) is applied, generating clusters of similar environments around distinct base environments. Top right: Schematic of fitnotype map for adaptive mutants near their home base environment. By measuring fitness in each of the green environments, one can infer how many fitnotypes matter for this set of mutants in their home environment. Here, only four of the possible 8 fitnotypes matter. Bottom right: When the mutants are moved to the distant base environment, and their fitness is measured in all pink environments (base and perturbations), there are two possibilities. Either more fitnotypes become important and the space appears higher-dimensional (left, pleiotropic expansion), or the set of fitnotypes that matters remains low-dimensional, but shifts (right, pleiotropic shift).

Predicting the effect of a #mutation on #fitness is hard. @oliviamghosh.bsky.social @petrovadmitri.bsky.social &co use fitness effects of adaptive yeast mutants to show that underlying genotype-phenotype-fitness maps are low-dimensional but context-dependent @plosbiology.org 🧪 plos.io/4dLy2Ez

Two models for the nature of pleiotropy in adaptation. Left: Schematic of the environmental structure in this study. Environments can be mapped onto a multidimensional environment space characterized by chemical and physical compositions. The large green circle represents an environment where adaptive mutants evolved, and the large pink circle is a distant environment. Around each base, a set of identical environmental perturbations (arrows) is applied, generating clusters of similar environments around distinct base environments. Top right: Schematic of fitnotype map for adaptive mutants near their home base environment. By measuring fitness in each of the green environments, one can infer how many fitnotypes matter for this set of mutants in their home environment. Here, only four of the possible 8 fitnotypes matter. Bottom right: When the mutants are moved to the distant base environment, and their fitness is measured in all pink environments (base and perturbations), there are two possibilities. Either more fitnotypes become important and the space appears higher-dimensional (left, pleiotropic expansion), or the set of fitnotypes that matters remains low-dimensional, but shifts (right, pleiotropic shift).

Predicting the effect of a #mutation on #fitness is hard. @oliviamghosh.bsky.social @petrovadmitri.bsky.social &co use fitness effects of adaptive yeast mutants to show that underlying genotype-phenotype-fitness maps are low-dimensional but context-dependent @plosbiology.org 🧪 plos.io/4dLy2Ez

Mountain Mutation Could Unlock a Natural Treatment for Nerve Damage A high-altitude survival gene may point to a new, naturally driven way to repair nerve damage. A genetic adaptation that helps animals thrive in extreme mountain environments may also reveal a new way to repair the human nervous system. Researchers have identified a mutation linked to life at high altitudes that appears to protect and even rebuild damaged nerve tissue, raising new possibilities for treating conditions such as cerebral paralysis and multiple sclerosis (MS). The study, published March 13 in Neuron, points to a built-in biological repair system that relies on compounds the body already produces. Instead of introducing foreign drugs, this approach could amplify natural processes that support nerve recovery. “Evolution is a great gift from nature, providing a rich diversity of genes that help organisms adapt to different environments,” says corresponding author Liang Zhang of Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. “There is still so much to learn from naturally occurring genetic adaptations.” The Role of Myelin in Brain Health Myelin is a protective coating that surrounds nerve fibers in the brain and spinal cord, helping signals travel quickly and efficiently. When oxygen levels are too low during early brain development, this layer...

Mountain Mutation Could Unlock a Natural Treatment for Nerve Damage
->SciTechDaily | More on "Nerve repair mountain gene mutation" at BigEarthData.ai | #BirdFlu #Mutation

ive been enjoying fallout 76 for about a week now, and naturally i made a fallout sona and of COURSE he gets mutated because im normal
#tf #transformation #mutant #mutation #fallout

Screenshot from .hack//Mutation

I seem overly critical, but I do think some of the “fresh” novelty from the first game isn't here to cover up the same problems the games had in Infection.

#dothack
#Mutation

The Genetic Foundations Of Blue Eye And Hair Colour Variability in Africa's #Rendille Tribe.
A Case study of the Biological Origin And #Genetic Basis of #BlueEyes and #BlondHair Genetic #Mutation in Human Populations
theorionblogown.blogspot.com/2024/09/the-...

#Science #Physics #Chemistry #Biology

Mutation des enseignants ? 

⚠️perdu dans les demandes de voeux ?⚠️

La CFDT vous accompagne via nos syndicats locaux 👇
lien vers tous nos syndicats en commentaire.

#education #professeur #professeurdesecoles #mutation

#Mutation of #Antisemitism.
Return & rise of antisemitism around the world.

How has antisemitism mutated over time?

Why does its return today present a #danger not just for #Jews,
but for all who #care about our #common #humanity?

Rabbi Jonathan Sacks

🔗 Mutation Logic Across All Domains Power adapts itself to maintain control even as old forms become unacceptable. Throughout history, when domination faces legal or societal backlash, it evolves into new methods that serve the same underlying functions—such as mass incarceration replacing slavery or surveillance superseding reproductive control—emphasizing a continuous cycle of mutation in systems of oppression.

#Mutation #domain

🔗 Combined Structural Diagram: The content examines how post-abolition captivity, modern war, and reproductive control share a mutation logic. Each system evolves after losing its previous form of domination, maintaining underlying functions while avoiding accountability. This continuity reveals a pattern whereby methods adapt but core functions, such as control and hierarchy, remain intact.

#captivity #mutation #war

2nd degré : Mouvement intra académique 2026 en Lorraine : certifiés, agrégés, PLP, CPE, Psy-En EDO EDA - SGEN-CFDT Education Formation Recherche Publiques Lorraine Qu’est-ce que le mouvement intra 2026 ? Le mouvement intra-académique 2026 dans l’académie de Nancy-Metz permet aux personnels d’enseignement, d’éducation et d’orientation du 2nd degré d’obtenir un nouveau poste ou une mutation pour la prochaine rentrée scolaire, selon les règles définies par l’académie, sous la responsabilité du Recteur. Les guides rectoraux donnent toutes les règles […]

Les pages de nos syndicats locaux : 
Versailles : https://f.mtr.cool/ovszguvwoi
Lorraine : https://f.mtr.cool/hujnfzivww

#mutation #mutation2026 #mutations2026
Suivez toutes les mutations avec le hashtag : #AGIRaveclaCFDTpourMUTATION

Mutation intra second degré : la CFDT vous accompagne - Fédération CFDT Éducation Formation Recherche Publiques Affecté dans une nouvelle académie à la rentrée 2026 ? Comment être aidé par les militants CFDT pour votre mutation intra second degré ?

Le calendrier de toutes les autres académies : https://f.mtr.cool/fgjmmlmqso

#mutation #mutation2026 #mutations2026
Suivez toutes les mutations avec le hashtag : #AGIRaveclaCFDTpourMUTATION

Viruses That Jump to Humans Don't Need Special Mutations, Study Finds - Science Alert When a virus jumps to humans from another species, it can seem like a supervillain bent on world domination – especially if it goes on to ignite a pandemic, as many zoonotic viruses have done in recent decades. And yet, despite the genuine danger zoonotic pathogens pose to human civilization, they're often just capitalizing on conditions we created, like our proximity to livestock, our degradation and invasion of wildlife habitats, and our trading of captive wildlife. In fact, according to a new study, most of the zoonotic viruses behind recent epidemics or pandemics were surprisingly unremarkable before they jumped to humans, with no clear evidence of prior adaptive changes predisposing them for such a leap. This challenges a common assumption about spillover events, which have long been seen as breakthroughs in which viruses leverage a novel adaptation. Instead, the new findings suggest our spillover risk may be even greater than we thought. If spillover depends less on sudden pathogen mutations than on our encountering existing ones, we're sitting ducks. The study also reinforces evidence that the outbreaks examined are consistent with viruses that jumped to us from other animal hosts rather than laboratory escapes. "This work has direct relevance to...

Viruses That Jump to Humans Don't Need Special Mutations, Study Finds - Science Alert
->ScienceAlert | More on "Zoonotic viruses jumping to humans" at BigEarthData.ai | #BirdFlu #Mutation #Science

#Hypertrophy #IronParadise #ClassicPhysique
#IFBBPro #BodybuildingMotivation #GymTok #FitFam #Mutation #MuscleComparison

The 20-Generation Ghost: How One Toxin Echoes Through Time In today's episode we're exploring a groundbreaking study that reveals how a single exposure to a common agricultural fungicide can impact health for twenty generations. We look at vinclozolin, a chemical once used on fruits and vegetables, and how it creates "epimutations" that worsen over time rather than fading away. From kidney disease to severe birth complications, the research shows these inherited risks accumulate, effectively echoing through centuries in human terms. We'll discuss why this challenges current safety regulations and what it means for our understanding of chronic disease,. References: - https://www.google.com/url?sa=E&q=https%3A%2F%2Fusrtk.org%2Fhealthwire%2Fone-exposure-twenty-generations-later-the-damage-is-unfolding%2F - https://www.google.com/url?sa=E&q=https%3A%2F%2Fwww.pnas.org%2Fdoi%2F10.1073%2Fpnas.2523071123 Support our work. Make a small donation. This removes any advertisements and help us continue bringing more interesting topics and confronting mainstream narrative on health. Click the Link to support us: https://www.spreaker.com/podcast/foodnourish-deep-dives--6602003/support

📣 New Podcast! "The 20-Generation Ghost: How One Toxin Echoes Through Time" on @Spreaker #biomarkers #chronic #disease #dna #environment #epigenetics #fertility #fungicide #generations #health #inheritance #mutation #pesticides #pregnancy #reproduction #research #science #toxicology #toxins

Mutation intra second degré : la CFDT vous accompagne - Fédération CFDT Éducation Formation Recherche Publiques Affecté dans une nouvelle académie à la rentrée 2026 ? Comment être aidé par les militants CFDT pour votre mutation intra second degré ?

Le calendrier de toutes les autres académies : https://f.mtr.cool/uopqglysoj

#mutation #mutation2026 #mutations2026
Suivez toutes les mutations avec le hashtag : #AGIRaveclaCFDTpourMUTATION

Tribe in Kenya Evolved Genetic Mutation That Lets Them Survive with Almost No Water For thousands of years, the nomadic Turkana people have lived across the sun-baked expanses of northwestern Kenya, subsisting almost entirely on the milk, meat, and blood of their livestock. In an arid region where temperatures regularly reach a sweltering 122 degrees Fahrenheit (50 degrees Celsius) and water is perilously scarce, they have thrived on a high-protein diet that would probably make other humans sick with metabolic diseases. Now, an international team of scientists has uncovered the secret to their extraordinary resilience. They sequenced the genomes of 367 Turkana individuals and discovered unique evolutionary adaptations that allow their kidneys to aggressively conserve water and safely process heavy loads of animal protein. But the same genetic edge that made these people so successful in the African outback is also a liability in the modern age. As climate change and economic shifts drive more Turkana into urban centers, these ancient genetic advantages are clashing with sedentary city lifestyles and the novel diets that come with them. This rapid transition leaves them highly vulnerable to chronic conditions like diabetes, hypertension, and kidney dysfunction. “The Turkana have maintained their traditional way of life for thousands of years, providing us with an extraordinary window into human...

Tribe in Kenya Evolved Genetic Mutation That Lets Them Survive with Almost No Water
->ZME Science | More on "Turkana genetic water conservation adaptation" at BigEarthData.ai | #Water #BirdFlu #Mutation #Indigenous

INTRA 2026 Le SNES-FSU vous accompagne ! Le calendrier – Du 20 mars au 6 avril 2026 midi : ouverture du serveur SIAM pour permettre la saisie de vos vœux (sous réserve de modification par le rectorat). – Le mercredi 18 mars, en visio, de 17h...

Plus de 150 collègues hier à la visio proposée par le @snes-fsu-toulouse.bsky.social pour préparer leur #mutation #Intra2026 !

Les adhérent-es peuvent maintenant disposer de #RendezVous individuels, en plus des informations génerales de notre site :

➡️ www.toulouse.snes.edu/spip.php?pag...

Precise, minimally evolved adenine base editors generated through mutation reversion analysis Activity of ABE7.10 single-residue reversion variants at episomal reporter and endogenous sites identifies both essential and dispensable mutations We previously reported that reversion of the single D108N mutation in ABE7.10 (to produce the editor that we call ABE7.10-N108D) resulted in an average 146-fold decrease in editing activity, as measured across 6 endogenous genomic sites in mammalian cells19. This suggests that the D108N mutation introduced in the first round of directed evolution of ABE7.10 was critical for both enhancing DNA editing activity by TadA and maintaining this activity even in the context of the 13 other acquired mutations. To investigate how the additional mutations in ABE7.10 impact base editing activity, we generated all 14 single-residue ABE7.10 reversion editors and evaluated their activities using a previously reported set of 8 episomal, highly sensitive, fluorescence turn-on reporters (Fig. 2a and Supplementary Discussion 1)12. We performed our reversion analyses using monomeric forms of ABE (TadA*-nCas9, where TadA* indicates a mutated TadA variant). While wild-type TadA is known to act as a dimer on its native tRNAArg substrate in E. coli11,20, and the crystal structure of ABE8e captures TadA* in a homodimeric form15, many researchers have found no significant difference in editing activity when delivering...

Precise, minimally evolved adenine base editors generated through mutation reversion analysis
->Nature | More on "Adenine base editor mutation analysis" at BigEarthData.ai | #BirdFlu #Mutation

Mutation intra second degré : la CFDT vous accompagne - Fédération CFDT Éducation Formation Recherche Publiques Affecté dans une nouvelle académie à la rentrée 2026 ? Comment être aidé par les militants CFDT pour votre mutation intra second degré ?

Le calendrier de toutes les autres académies : https://f.mtr.cool/baejoizxhy

#mutation #mutation2026 #mutations2026
Suivez toutes les mutations avec le hashtag : #AGIRaveclaCFDTpourMUTATION

Enseignant ? Envie de bouger de poste ? 

Les serveurs de mutation vont ouvrir les uns après les autres ces prochains jours.
Aujourd'hui : Rennes / Lille / Clermont-Ferrand / Bordeaux

#mutation #mutation2026 #mutations2026
Suivez toutes les mutations avec le hashtag : #AGIRaveclaCFDTpourMUTATION

Scientist with long black hair in lab coat with head phones around neck, and green hat wearing green beads bracelets, between a female and male radio host.

Join Dr Rina, Bec & Asa on Drive on Wednesday 18th March, on 98.5 Sonshine FM - #Science (Wed) 🍀
Tune in or listen online: www.sonshine.com.au/player/sonsh...
Missed it? Segment is available on Sonshine's website (up to one week).

#scicomm #radio #rinawong #rinafu #DrRina #mutation

Release 1.0.12 · rife2/bld-pitest Summary Support PIT version 1.23.0 Support for new configDir option What's Changed in 1.0.12 Add configDir option in aee8579 Bump Extensions Tools to version 0.9.1-SNAPSHOT in 17a1616 Bump PIT t...

I've just released version 1.0.12 of the PIT Mutation Testing Extension for bld

#bld #buildsystem #buildtool #github #java #mutation #pit #pitest #testing

github.com/rife2/bld-pi...

Transmission héréditaire : pourquoi certaines maladies sautent-elles des générations ? Certaines maladies génétiques semblent disparaître pendant une génération avant de réapparaître chez des descendants. Ce phénomène intrigue souvent les familles concernées. Il s’explique par les mé...

🧬 Pourquoi certaines #maladies #génétiques semblent-elles "sauter" une génération ?
👉Parfois, une #mutation est présente sans provoquer de symptômes chez les parents, puis la maladie apparaît chez les enfants ou petits-enfants.

www.futura-sciences.com/sante/questi...

Mouvement/mutations intra 2nd degré dans l'académie de Strasbourg : où ? quand ? comment ? - Éducation Formation Recherche Publiques Alsace Mutations intra académiques dans l'académie de Strasbourg : la CFDT vous conseille pour réussir votre mouvement intra

Les pages de nos syndicats locaux : 
Normandie : https://f.mtr.cool/bvhszwqtpr
Strasbourg : https://f.mtr.cool/xhcbeygrbg

#mutation #mutation2026 #mutations2026

In a dark, Umbrella laboratory corridor, a torch/flashlight beam illuminates a monster, whose glowing yellow eyes stare back at you with lethal hunger. Its mandibles are spread wide, with drool dripping from its monstrous fangs. It stands on all fours, claws scraping on the floors, whole dark, shaggy fur covers its back. Its large, bat-like ears could definitely hear your fearful breath.

Artfight 2025
ProjectMayhem's OC Silas

#artfight #artfight2025 #crystals2025 #artfightcrystals #artfightattack #art #digitalart #monsterart #monster #residentevil #biohazard #fantasy #fantasyart #oc #originalcharacter #monsteroc #bioweapon #tvirus #umbrella #umbrellacorp #hybrid #mutation #horror