A randomized #ClinicalTrial shows that #Allogeneic dental pulp stem cell injections enhance periodontal regeneration and improve clinical outcomes, thereby supporting a safe, minimally invasive stem-cell therapy for #Periodontitis. @pku1898.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

A phase 1b/2 trial shows that #allogeneic #NKcell therapy plus #chemotherapy is safe in #AdvancedPancreaticCancer, with 31.6% response; #MultiomicProfiling reveals NK/T‑cell subsets linked to outcomes, offering novel immune insights.

#OpenAccess in STTT: doi.org/10.1038/s413...

Per-Ola Carlsson

Sonja Schrepfer

Drs. Per-Ola Carlsson, Sonja Schrepfer, & a team at Sana Biotechnology transplanted genetically modified #allogeneic donor #islets into a man with long-standing #Type1Diabetes.

Read the results in @nejm.org: bit.ly/4lmcajr
Listen to the discussion: bit.ly/4ooU5Ut

A diagram illustrates the concept of allogeneic transplants, featuring a woman with an arrow pointing to a blood bag, followed by another arrow pointing to a group of people, representing the donation of cells or tissues from a genetically different individual of the same species.

Welcome to Wednesday Words, where I will define one word used in biotechnology or biopharma each Wednesday morning!

If you want to learn more, check out: sbee.link/9nwfx3q7ph
#wednesdaywords #biotechnology #biopharma #Allogeneic #MedicalScience #science

Safety and activity of CTX130, a CD70-targeted allogeneic CRISPR-Cas9-engineered CAR T-cell therapy, in patients with relapsed or refractory T-cell malignancies (COBALT-LYM): a single-arm, open-label,... In patients with heavily pretreated T-cell lymphoma, CTX130 showed manageable safety and a promising objective response rate. This study shows that allogeneic, readily available CAR T cells can be saf...

www.thelancet.com/journals/lan...

#CARTherapy #TcellLymphoma #ClinicalResearch #MedicalAdvances #celltherapy #immunotherapy #IO #genetherapy #allogeneic 📚

$PSTX platform includes non-viral capabilities to design, develop and manufacture #allogeneic, T stem cell memory-rich #CART therapies. The acquisition will establish a new capability for Roche in allogeneic #celltherapy, with CAR-T programs in hemato malignancies, solid tumors & autoimmune diseases