This review summarizes #VEGF signaling in #VascularDevelopment and disease, highlighting progress in VEGF-targeted therapies, resistance mechanisms, and emerging strategies such as combination and smart delivery approaches. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Advert for an IDRM Seminar Series talk. On the left hand side of the poster is the logistical information which includes the following: 3-4pm, Wednesday 12th February 2025, IDRM Seminar Rooms 1 and 2. Title reads Mapping vascular developmental pathways with in viv perturb-seq. Hosted by Dr Oliver Stone. A small circular photo of Dr Stone is shown next to his name. On the upper half of the right hand side of the poster is a large circular headshot of the speaker. Below is her name, Dr Kristy Red-Horse, and her current place of work, Department of Biology and Institute for Stem Cell Biology and Regenerative Medicine, Standford University. At the lower right hand side of the poster are 4 logos representing from left to right the Institute of Developmental and Regenerative Medicine, the University of Oxford, the Department of Paediatrics and the Department of Physiology, Anatomy and Genetics.

Our February IDRM Seminar Series guest speaker is Kristy Red-Horse. We're looking forward to learning more about her research in the field of cardiovascular biology when she joins us on Wednesday.

#RegenerativeMedicine #VascularDevelopment

Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution | Circulation Research BACKGROUND: Mature endothelial cells (ECs) are heterogeneous, with subtypes defined by tissue origin and position within the vascular bed (ie, artery, capillary, vein, and lymphatic). How this heterog...

🚀 New Insights into Endothelial Cell Development! 🧬

Thanks to #MERFISH spatial transcriptomics a team uncovered how tissue origin and vascular positioning shape blood vessel formation.

#SpatialTranscriptomics #MERFISH #SingleCell #VascularDevelopment #CRISPR

www.ahajournals.org/doi/10.1161/...