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#
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#BispecificTcellEngagers
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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
1 month ago
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A modular albumin-based #BispecificTcellEngagers platform uses SpyCatcher/SpyTag for rapid tumor targeting, extended half-life, dose-dependent cytotoxicity, and stronger suppression than #Cetuximab in #BreastCancerModels.

#OpenAccess in #STTT: doi.org/10.1038/s413...

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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
3 months ago
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Researchers identify #hypoxia-driven #VEGF secretion & EMT as key resistance mechanisms to MUC16-targeted #BispecificTcellEngagers in #OvarianCancer, with VEGF inhibition restoring T-cell cytotoxicity and immunotherapy response. @harvardmed.bsky.social

#STTT: doi.org/10.1038/s413...

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