🟢Today, members of the APPEAL consortium presented recent project outcomes at the 7th Central German Meeting on Bioinformatics (“Mittelerde Meeting 2026”) in Halle, Germany.
#Bioinfomatics #HorizonEU #AntiviralResearch #PandemicPreparedness

A first step toward collaboration: at the 23 March 2026 meeting, APPEAL and NoVir explored potential synergies and future cooperation. NoVir was presented by A. Pichlmaier (TUM), followed by a fruitful exchange.
#HorizonEU #EUProjects #ResearchCollaboration #Innovation #AntiviralResearch

Aromatic π-Stacking Stabilizes an α-Helical SARS-CoV-2 MPER Peptide that Mimics the Post-Fusion Spike and Enables Potent Antiviral Activity | ChemRxiv Membrane fusion between SARS-CoV-2 and host cells is mediated by the spike protein and involves the membrane-proximal external region (MPER), a tryptophan-rich sequence implicated in viral entry. Here, we investigated the feasibility of MPER-derived ...

Excited to share a new preprint from our group @chemunicologne.bsky.social @unicologne.bsky.social!

chemrxiv.org/doi/full/10....

Big thanks to our collaborators at University of Florence!

#NMR #StructuralBiology #AntiviralResearch #Peptides #SARSCoV2 #DrugDesign #Biophysics #Collaboration

📣APPEAL outcomes will be presented at 7th Central German Meeting on Bioinformatics (Mittelerde Meeting, 26–27 March, Halle, Germany) in 1 talk and 4 posters. Don’t miss Alicia Hiemisch’s talk from Jena University Hospital on 27 March at 15:50.
#Bioinfomatics #HorizonEU #AntiviralResearch

📣APPEAL consortium members are presenting recent project results at #GfV26 in Heidelberg.
Meet us at the poster session: P161, P381, P386, P393 and P492.
#HorizonEU #AntiviralResearch #PandemicPreparedness

Rehwinkel Group: Nucleic Acid Sensing

🔗 Rehwinkel Group lab page:
www.rdm.ox.ac.uk/about/our-di...

#WIMMSpotlight #WIMMCommunity #Immunology #InnateImmunity #AntiviralResearch #Interferon #PhDStudent #MRCWIMM

Oral 4′-fluorouridine rescues nonhuman primates from advanced Lassa fever - Nature Treatment with 4′-fluorouridine (also known as EIDD-2749) in an African green monkey (Chlorocebus aethiops) model of Lassa disease resulted in complete clearance of infectious virus in a high proportion of cases and prolonged survival to the pre-determined study end-point in all cases.

Emerging infectious diseases

New in Nature: the oral antiviral 4′-fluorouridine protected non-human primates from lethal Lassa fever when administered at an advanced stage of infection.

Read more: https://www.nature.com/articles/s41586-025-09906-y

#HighConsequencePathogens #AntiviralResearch

Viruses, cancer, and a protein called p53: #AntiviralResearch #AnticancerResearch #HealthScience
But, the list of viruses is growing. According to one paper, the list includes smallpox, HIV, and influenza viruses to name a few. This is exciting - better understanding can lead to better treatments.

Viruses, cancer, and a protein called p53: #AntiviralResearch #AnticancerResearch #HealthScience
The role of p53 in cancer has been known for some time, but its role in viral replication (where viruses produce many more viruses that then infect more cells) is less well understood.

Viruses, cancer, and a protein called p53: #AntiviralResearch #AnticancerResearch #HealthScience
Did you know that there is a common gene/protein/network with roles in both cancer and viral infections? Yes, this network has as a central regulator the p53 gene and protein.

Newsletter - AVITHRAPID project Sign up Sign up and stay informed about the progress and developments of the AVITHRAPID project. You can unsubscribe at any time by clicking the link in the footer of the newsletter E-mails. We use Mailchimp as our marketing platform. By clicking below to subscribe, you acknowledge that your information will be transferred to Mailchimp for processing. Learn more about Mailchimp’s privacy practices. Newsletter Archive Newsletter 3 November 2025 Newsletter 16 June 2025 Newsletter 10 March 2025 Newsletter 4 November 2024

Targeting the virus is not enough.
AVITHRAPID explores host-directed antivirals, reducing resistance and enabling broad-spectrum preparedness.
Innovation for future pandemics.

🔗 avithrapid.eu/newsle...

#AVITHRAPID #AntiviralResearch

🌐 AVITHRAPID Project Portal - your gateway to antiviral R&D and pandemic preparedness.

🔗 Discover more: avithrapid.eu/projec...

#AVITHRAPID #InnovationGateway #AntiviralResearch #Preparedness"

10 genes > entire antiviral arsenal? 🤯
Columbia researchers found a cocktail of ISG genes that fights viruses WITHOUT the inflammatory chaos. Inspired by patients who are naturally resistant to viruses. Science is wild!
Full story: buff.ly/TXO360x
#AntiviralResearch #ISG15 #ScienceIsWild

Huge congrats to Dr. Adriana Forero! 🎉
Just landed a $505K Burroughs Wellcome Fund award for her work showing that immune readiness isn't random - it's actually encoded in how our cells are built. Pretty mind-blowing stuff about antiviral immunity!
#CytokineSociety #BWFAward #AntiviralResearch

Cidara Therapeutics ($CDTX) is gearing up for Phase 2b results of its flu antiviral, CD388, this month. Analysts are bullish, with price targets up to $50. Stock up 4.6% post-earnings.

Read more: www.valuethemarkets.com/analysis/cid...

#CDTX #BiotechStocks #AntiviralResearch #ValueTheMarkets

AI Accelerates Antiviral Discovery with Limited Data A groundbreaking AI method developed by University of Pennsylvania researchers accelerates the discovery of antiviral compounds, even with limited data—offering a promising tool in the fight against viral diseases.

New AI technique from UPenn identifies potent antivirals with minimal data, revolutionizing drug discovery. #AIinMedicine #AntiviralResearch #UPennInnovation

Human Structural Homologues of SARS-CoV-2 PL pro as Anti-Targets: A Strategic Panel Analysis COVID-19 is caused by SARS-CoV-2, a highly transmissible and pathogenic RNA betacoronavirus. Developing small-molecule antiviral inhibitors of the SARS-CoV-2 papain-like protease (PL pro ) is advantag...

🔬 New insights into SARS-CoV-2 drug development – @wsuapplebaum researchers identify human PLpro homologues, advancing antiviral therapies.

🔗 Read the study: pmc.ncbi.nlm.nih.gov/articles/PMC...

#WayneState #SARSCoV2 #AntiviralResearch #DrugDevelopment

Triple Drug Combo Halts Enterovirus Infections This orally available antiviral cocktail ‘protected human pancreatic, eye, lung, heart, and brain organoids from enterovirus-mediated death’—a promising leap toward treating diseases from hand-foot-an...

A three-drug oral combo showed in vitro protection of human organoids—including pancreatic, cardiac, and neural tissue—from enteroviruses.
The findings support further investigation into broad-spectrum antiviral strategies.
#AntiviralResearch #MedSky

Frontiers | FDA-approved drug repurposing screen identifies inhibitors of SARS-CoV-2 pseudovirus entry

🧪 Drug repurposing using pseudotyped virus
A recent study used a SARS-CoV-2 pseudotyped virus system to screen drugs for potential inhibitors of viral entry. frontiersin.org/journals/pha...
#PseudotypedVirus #SARSCoV2 #Virology #AntiviralResearch #COVID19 #VirusEntry #Pseudotyping

Recombinant protein HR212 targeting heptad repeat 2 domain in spike protein S2 subunit elicits broad‐spectrum neutralizing antibodies against SARS‐CoV‐2 and its variants 1. HR212 assembles to be a trimer with three HR2s exposed. 2. The nAbs induced by HR212 showed inhibition of HR1 binding with HR212 and the nAbs induced by HR212 would block the S2 conformational rea....

Targeting SARS-CoV-2 spike HR2: Researchers designed HR212, a recombinant protein that inhibits viral infection across 28 pseudotyped variants. This highlights its potential as a broad-spectrum antiviral. #COVID19 #virology #pseudotyping #antiviralresearch onlinelibrary.wiley.com/doi/10.1002/...

Advances in Mini Gut Organoid Models Reveal Key Insights into Norovirus Replication Sasirekha Ramani, PhD on creating a broad-spectrum antiviral that could be effective in various clinical settings, especially given the emergence of new and more dominant strains.

Part 2 of our interview with Dr. Sasirekha Ramani, discusses how 2′-fucosyllactose (2′FL) could be key to blocking norovirus replication. #Norovirus #AntiviralResearch #GutHealth #IDsky #MEDsky

Listen here: www.contagionlive.com/view/advance...

🦠 Which virus could cause next pandemic? What worries you most?

🔹 New coronaviruses (zoonotic spillover)
🔹 Re-emerging viruses (i.e. Zika, Dengue)
🔹 Antiviral resistance (mutation risks)
🔹 Disease X (unknown future pathogen)

🗳 Let's discuss

#FuturePandemics #OneHealth #AntiviralResearch

🔬 #Postdoc Opportunity in #AntiviralResearch! Join our team to explore broad-spectrum antiviral compounds to combat viruses like DENV, Influenza A, RSV, and SARS-CoV-2. Perfect for a driven scientist with a passion for #virology and #drugdevelopment.