Talked a bit at #SCHD26 abt how I came to @fredhutch.org & got involved in #cancer #research & learned abt #healthdisparities by first being diagnosed w/ #nolump #lobular #breastcancer. Funny how life works out. TY @binaytara.bsky.social @lobularbca.bsky.social #CanSky @enddisparities.bsky.social

A pleasure having Professor Steffi Oesterreich @upmchillmancc.bsky.social @upmc.com @mageewomens.bsky.social visit us at @wchospital.bsky.social today and discussing #research collaborations in #lobular #breastcancer #bcsm
@lobularbca.bsky.social

The surprising way breast cancer screenings could reveal heart disease A new study finds AI can potentially detect artery calcification in routine mammograms, helping identify women at risk of heart disease, the leading cause of death.

" ... when ppl see a visualization of what’s going on in their arteries, something clicks & they get motivated.'" 2/2 #CanSky

Just a reminder that mammograms aren't that good at detecting #lobular #breastcancer yet, esp w/ #densebreasts. Let's fix that, too!

www.washingtonpost.com/health/2026/...

10 Years NED: A Survivor’s Journey I’m ending this year officially 10 years NED — No Evidence of Disease. Some people call it remission. I like to say I’m in a long-term relationship with NED.

I can’t believe I’m ending the year 10 years NED. I was dx with invasive #lobular in my 30’s. My feelings are complex, so here’s a short blog post about it. #breastcancer #survivorship #blogger

Pic credit: @breastcancerorg.bsky.social

warriormegsie.com/2025/12/27/1...

Homepage - San Antonio Breast Cancer Symposium

Really great session on #lobular #breastcancer at #SABCS25. TY Steffi Oesterreich, Otto Metzger, Anne Vincent Salomon, Flora Migyanka, etc. 4 sharing key insights N2 our oddball #breastcancer subtype. Gr8 2 know there are more #clinicaltrials coming! @elbcc-2018.bsky.social @lobularbca.bsky.social

This Giving Tuesday, stand with LBCA in support of the lobular breast cancer community. Donate today to fuel ILC research, awareness, education, and advocacy: lobularbreastcanceralliance-bloom.kindful.com #GivingTuesday #LBCA #lobular #ILC #invasivelobularcarcinoma #breastcancer

Radiation therapy for lobular breast cancer: opportunities and challenges for leveraging radiosensitivity - PubMed Invasive lobular carcinoma (ILC) is the most common special histological subtype of breast cancer, accounting for 15% of cases. ILC has unique clinical and molecular characteristics yet is treated largely agnostic of subtype. We explore challenges and opportunities in treating ILC, focusing on the u …

Always happy 2C more focused research on #lobular #breastcancer! TY @mjsikora.bsky.social 🙏

Conclusion: #ILC presents unique clinical challenges among #breastcancers, from its subtle manifestation making early detection difficult, 2 resistance 2 convent'al txs like chemo & ..." 1/2 #CanSky #Bcsm

Additional information can be found at lobularbreastcancer.org @lobularbca.bsky.social

I did not find a lump as was stated in the story. Please report any changes to your doctor. Lobular has a different presentation that other breast cancers. A lump is not typically formed. #lobular

#LOBSTER trial #GBG118 for pts with #lobular #breastcancer: It investigates whether the combination of #capivasertib + #fulvestrant can achieve a stronger therapeutic effect than fulvestrant alone – aiming to reduce #recurrence risk and improve quality of life.
👉 www.gbg.de/en/trials/lo...

What you need to know about lobular breast cancer Dr. Cassann Blake, a breast surgical oncologist at the Cleveland Clinic, on lobular breast cancer.

Great 2C #lobular #breastcancer coverd by @cbsnews.com but it wld have been helpful 2 mention:

*Lobular #BC dsn't usually make lumps
*So it's often not felt or seen on mamms
*Esp in dense breast tissue
*It's abt changes, not lumps!
*More info @lobularbca.bsky.social
#CanSky #MedSky #CancerBS #bcsm

Coming right up Wed Oct 15! 👀

Join me & other #lobmob members 4 #ILC insights from @fredhutch.org #lobular #breastcancer experts Chris Li, Hannah Linden & Diana Lam. #CanSky @elbcc-2018.bsky.social 👇
Spotlight on lobular #BC: What pts, PCPs & oncologists need to know
share.google/Lx4Fcu6Ar7mu...

Spotlight on lobular breast cancer: What patients, PCPs & oncs need to know Hear from Fred Hutch experts about lobular breast cancer's history, screening & surveillance challenges, new findings & clinical trials.

Very pleased to see this report from @americancancersoc.bsky.social on #lobular #breastcancer acsjournals.onlinelibrary.wiley.com/doi/10.1002/...

Learn more abt #lumpless #lobular at this FREE special spotlight presentation @fredhutch.org Oct 15, 3-5pm. Read more and register here. 👇

"Conclusion: ILC (invasive #lobular #breastcancer) has distinctive characteristics that can contribute 2 delayed detection, resistance 2 therapy & poorer prognosis 4 adv disease. Differentiating ILC from ductal #BC in research & clinical trials could help identify risk factors ..." 1/2 #CanSky #bcsm

Spotlight on lobular breast cancer: What patients, PCPs & oncologists need to know Hear from Fred Hutch experts about lobular breast cancer’s history, screening and surveillance challenges, new findings and clinical trials.

Curious abt #lumpless #lobular #breastcancer? I'm hosting this event on Wed, Oct 15, 3-5 pm at #FredHutch @fredhutch.org in #Seattle w/Drs. Chris Li, Hannah Linden & Diana Lam. Learn abt #lobularBC history #imaging issues, new research & #CTs! #lobmob #CanSky @thankscancer.bsky.social #bcsm #lbca

Ep #17: Dr. Matt Sikora on breast cancer research with patients at the center

I had the amazing opportunity to chat w @projbridgeco.bsky.social to talk about the lab, my career, studying #lobular breast cancer, and working w patient advocates. Loved talking re where I've been & talk about what's important to me as a PI and mentor!

Spotify: open.spotify.com/episode/0NBd...

Really nice to see #lobular #breastcancer get its own session at the recent Canadian Breast Cancer Symposium #CBCS25, with @lobularbca.bsky.social board members in attendance!

Invasive Lobular Breast Cancer: 'Moon Shot Project' Dr Susan Michaelis initiated the 'Lobular Moonshot Project' in 2023 to raise funding specifically for research into lobular breast cancer. #LobularMoonShotProject #LobularBreastCancer

15% of all breast cancers are Lobular, 2000 per day. It's hard to detect, with little knowledge of its biology, so no specific treatments. The Lobular Moon Shot project is tirelessly pursuing support for ambitious, life changing research #LivedExperience #Lobular #BreastCancer #LobularMoonShot

Clinical challenges and proposed solutions for patients with invasive lobular breast cancer Invasive lobular carcinoma (ILC) is the second most common type of breast cancer and is increasingly recognized as a separate entity from invasive breast cancer of no-special type. Here, we present th...

I enjoyed reading this well-thought-out review on clinical challenges and proposed solutions for patients with invasive #lobular #breastcancer Oncologywww.annalsofoncology.org/article/S0923-7534%2825%...

Radiation therapy for lobular breast cancer: opportunities and challenges for leveraging radiosensitivity - npj Breast Cancer npj Breast Cancer - Radiation therapy for lobular breast cancer: opportunities and challenges for leveraging radiosensitivity

New review from us on radiation in #lobular breast cancer!
www.nature.com/articles/s41...

Lots of anecdote that ILC is highly responsive to XRT (despite ~chemoresistance), but do we have the data?

led by Dr. Michael Boysen (now resident at Trinity Health Ann Arbor), w Dr. Corey Speers @ UAB. 🧵1/n

We did a thing w @jostrander.bsky.social!
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n

Congrats to Dr. Maggie Musick on her 1st lead-author study in the lab! This #lobular project with @jostrander.bsky.social has been so much fun over the last few years.

Blue-torial soon, after a grant gets out the door this week 🫠

Cool stuff 🎉👏 @mjsikora.bsky.social
@jostrander.bsky.social #bcsm #lobular 🧪🧬

May the Fourth be with you.

Carved in my memory and on my chest, it's my seventh mastectoversary.

A tough old road, but still here.
#ThanksCancer #BreastCancer #LobMob #Lobular #ILC #CanSky

Histology DOES matter in breast cancer biology! Really excited for #lobular to be featured at #AACR25 and to share the stage with Drs. Steffi Oesterreich and Christina Curtis.

Matt in front of the cover slide reading 'Social determinants of health and cancer outcomes: from the sidewalk to the bench and back again".

Made it to AACR! This is my 20 year anniv of membership, w/ my first meeting in 2005 as an undergrad Bardos Scholar.

On Monday I'll be speaking in #lobular breast cancer session -
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Kicking off #AACR25 on the cancer disparities track!

@theaacr.bsky.social

The transcriptomic architecture of common cancers reflects synthetic lethal interactions - Nature Genetics Tumor cells upregulate compensatory buffering genes following tumor suppressor loss. These genes may represent new synthetic lethal partners that could be harnessed therapeutically.

Uncovering synthetic lethal vulnerabilities across cancers. Upregulation of #TWIST1/2, #VIM, and integrin components ( #ITGB5, #ITGAV, #FERMT2 ) constitutes a synthetic lethal buffering mechanism that preserves tumor fitness despite #CDH1 #Ecadherin loss #lobular #DGC
www.nature.com/articles/s41...

Micro-Grant Program – Breast Cancer Care & Research Fund

The Sikora Lab & @cucancercenter.bsky.social rcvd a 2025 microgrant from the Breast Cancer Care & Research Fund to support our #lobular breast cancer outreach with @charlevo.bsky.social and Front Range ILC! BCCRF helped get FRILC off the ground in '22 and we're grateful for their ongoing support.

Enjoyed speaking on #lobular #breastcancer at the 2025 updates in #generalsurgery conference. @uoftsurgery.bsky.social

Looking forward to speaking about #TNBC at the lunchtime symposium .

Wonderful presentations from a truly inspiring #Lobular Breast Cancer Symposium 2024 in Leuven!
Happy viewing! #CDH1 #ILC #TME #ImmunoILC #LOXL1 @elbcc-2018.bsky.social
www.youtube.com/watch?v=g7IN...
www.youtube.com/watch?v=g7IN...
www.youtube.com/watch?v=P56x...
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