Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2–Fibronectin 1–Integrin signaling axis as a prognostic determinant in colorectal cancer - Molecular Biomedicine Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with its heterogeneous molecular profiles complicating prognosis prediction. Multi-omics profiling of clinical CR...

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Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2–Fibronectin 1–Integrin signaling axis as a prognostic determinant in #ColorectalCancer doi.org/10.1186/s435...

#Myofibroblasts #ExtracellularMatrix #TNS1 #FERMT2

The transcriptomic architecture of common cancers reflects synthetic lethal interactions - Nature Genetics Tumor cells upregulate compensatory buffering genes following tumor suppressor loss. These genes may represent new synthetic lethal partners that could be harnessed therapeutically.

Uncovering synthetic lethal vulnerabilities across cancers. Upregulation of #TWIST1/2, #VIM, and integrin components ( #ITGB5, #ITGAV, #FERMT2 ) constitutes a synthetic lethal buffering mechanism that preserves tumor fitness despite #CDH1 #Ecadherin loss #lobular #DGC
www.nature.com/articles/s41...