Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2–Fibronectin 1–Integrin signaling axis as a prognostic determinant in colorectal cancer - Molecular Biomedicine Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with its heterogeneous molecular profiles complicating prognosis prediction. Multi-omics profiling of clinical CR...

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Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2–Fibronectin 1–Integrin signaling axis as a prognostic determinant in #ColorectalCancer doi.org/10.1186/s435...

#Myofibroblasts #ExtracellularMatrix #TNS1 #FERMT2

Endoglin mediates the tumor- and metastasis-promoting traits of stromal myofibroblasts in human breast carcinomas

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#Endoglin #BCSM #Myofibroblasts

Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease - Nature Reviews Nephrology Kidney fibrosis is a key pathological process in chronic kidney disease. Here, the authors examine how the metabolic reprogramming of kidney immune and non-immune cells in response to injury can promo...

CKD affects >10% globally, marked by fibrosis from ECM buildup. #Myofibroblasts drive this via tubule-immune crosstalk. Understanding this pathway is crucial. #CKD #Health #Fibrosis PMID:39289568, Nat Rev Nephrol 2024, @NatRevNeph doi.org/10.1038/s415...