Elevated S100A9 in #HFpEF hearts drives oxidative stress and mitochondrial dysfunction; its deficiency restores #SIRT3 signaling, improves diastolic function, and reduces #hypertrophy and #fibrosis, supporting S100A9 as a therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...
🫀 Just published online in JPS❣️
“SIRT3-dependent enhancement of apelinergic signaling mediates the cardioprotective effects of late-life high-intensity interval training”
— Qiaowei Li et al.
🔗 doi.org/10.1016/j.jp...
#CardiacPhysiology #ExerciseTraining #SIRT3 #Apelin #NowOnline #JPhysiolSci
This letter reports that #AAV‑mediated #SIRT3 upregulation in nigral #dopamine #neurons preserves mitochondrial function, sustains DA activity, and prevents age‑related #motordecline and muscle loss, highlighting SIRT3 as a therapeutic strategy.
#STTT: doi.org/10.1038/s413...
This research letter discusses how #SIRT3 upregulation in nigral #dopamine #neurons preserves mitochondrial function, protects the #nigrostriatal pathway, and prevents #agerelated motor decline and muscle loss. #aging #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
🌿 A recent review in The FASEB Journal spotlights honokiol as a powerful SIRT3 activator, enhancing mitochondrial function, reducing inflammation, and offering therapeutic promise across age-related and chronic diseases.
🔗 buff.ly/No4D2ct
#SIRT3 #Mitochondria #Honokiol #FASEBJournal
CCM Biosciences Pioneers New Therapeutics for Longevity Using Innovative Enzyme Activation Approaches #USA #Mount_Laurel #Longevity #CCM_Biosciences #SIRT3
The semester flew by!
TOMORROW @ 4:00PM, please join us for our final #GIresearch seminar 😥 before we break for winter holidays ❄️
Closing us out is Dr. Qiang Tong, who will share his lab's findings of #SIRT2 and #SIRT3 regulation in #metabolism and #aging.
See you there! #GIsky #Liversky
