Bitter Reception Gentiana lutea

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#Plant #secmet #natprod #ChemSky

📢Our latest issue is now online!

Check out the review behind the cover by Hongzhi Tang, Linquan Bai, Sang Yup Lee, Yaojun Tong & co. at Shanghai Jiao Tong University summarising recent progress in the discovery & applications of halogenases and dehalogenases #natprod

pubs.rsc.org/en/content/a...

Hot off the Press A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as candindole A from Aspergillus…

🔥Check out the first Hot off the Press article of 2026 by Robert Hill & @andysuth14.bsky.social at @uofgchem.bsky.social on their selection of 32 recent papers covering the latest research in bioorganic chemistry & novel natural products #naturalproducts #natprod

Synthetic biology for heterologous expression and engineering of fungal polyketide synthases Covering: up to 2025Polyketide synthases (PKSs) are essential enzymatic systems that produce a wide range of natural products. Their biosynthetic features offer significant opportunities to create a…

🔓Take a look at this #OpenAccess Highlight article from Pablo Cruz-Morales & co. @wemakemolecules.bsky.social discussing synthetic biology for heterologous expression and engineering of fungal polyketide synthases #secmet #natprod

📍 @dtu.dk

Is Glycyrrhizin a Prodrug Therapeutic Activity of Licorice (Glycyrrhiza glabra) Root

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#Plant #secmet #natprod #ChemSky

Streptomyces as a versatile host platform for heterologous production of microbial natural products Focus on 2004 to 2024 The rediscovery of natural products (NPs) as a critical source of new therapeutics has been greatly advanced by the development of heterologous expression platforms for…

🔓Be sure to read in our latest issue this #OpenAccess review by Andriy Luzhetskyy & co. @uni-saarland.de examining the use of Streptomyces as a versatile host platform for heterologous production of microbial natural products #secmet #natprod

Find the full article here🔽

Enantioselective synthesis of antibiotic inducing gamma-butenolides from Streptomyces rochei and derivatives Given the challenges of discovering new natural products, further investigations into the regulatory systems that control their production are needed. Herein, we describe an enantioselective,…

🔓Read #OpenAccess research by Elizabeth Parkinson et al. at @purduechemistry.bsky.social in our latest issue describing the enantioselective synthesis of antibiotic inducing gamma-butenolides from Streptomyces rochei #orgchem #natprod

Find their full report here🔽

Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we…

🔓Don't miss this #OpenAccess Viewpoint by @philmuslab.bsky.social & co. discussing the challenges & solutions to unlocking the potential of cyanobacteria in drug discovery #secmet #natprod

Check it out in full below👇

Inhibitory effects of 1−18 on FN levels in TGF-β1-stimulated LX-2 HSCs.

🧪 New anti-liver fibrosis leads from Euphorbia wallichii.

A CJNM study reports 12 diterpenoids (Euphorwallnoids A–L), including a rare 5/7/6/5 tetracyclic scaffold. Compound 1 suppresses fibronectin, α-SMA, and collagen I in LX-2 cells.

Full read: doi.org/10.1016/S187...

#Fibrosis #NatProd #CJNM

Effective Phytochemical Variance Ratio Structure and Clinical Endpoints

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#Plant #secmet #natprod #ChemSky

Accelerating enzyme discovery and engineering with high-throughput screening Covering: up to August 2024 Enzymes play an essential role in synthesizing value-added chemicals with high specificity and selectivity. Since enzymes utilize substrates derived from renewable…

🔓Check out the #OpenAccess review by @pabnik.bsky.social & co. @labnikel.bsky.social in our latest issue exploring emergent strategies and methods for isolating, creating & characterizing enzymes optimized for bioproduction #natprod

Read in full on our website🔽

Enhanced Absorption and Product Labeling A Student Assignment

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#Plant #secmet #natprod #ChemSky

The Ugi–Joullié three-component reaction (UJ-3CR) and related reactions: recent developments, mechanistic aspects and synthesis of natural products and bioactive compounds The Ugi–Joullié three-component reaction evolved from the classic Ugi four-component reaction and enables the facile and efficient formation of polysubstituted nitrogen heterocycles from cyclic…

Don't miss this review in our latest issue by Teodoro Kaufman et al. from Universidad Nacional de Rosario looking at recent developments and mechanistic insights of the Ugi–Joullié three-component reaction #orgchem #natprod

Check it out in full here🔽

📢Our latest issue is now online!

Check out the paper behind the cover from Guidong Lu, Minshou Wang, Shizhi Jiang & co. at Dali University describing the synthesis of a series of novel meroterpenoid natural products #orgchem #natprod

pubs.rsc.org/en/content/a...

🎉We are delighted to announce that the 2026 Natural Product Reports Emerging Investigator Lectureship has been awarded to Jakob Franke (@unihannover.bsky.social)

Please join us in congratulating him! #chemsky #natprod #secmet

Read more about Jakob and his research🔽
blogs.rsc.org/np/2026/03/1...

Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we…

🔓Take a look in our latest issue at this #OpenAccess review by Stephanie Heard & Alessandra Eustaquio @eustaquiolab.bsky.social looking at the development of Burkholderia bacteria as heterologous hosts #natprod #secmet

📍 @uofilsystem.bsky.social
pubs.rsc.org/en/content/a...

Ashwagandha Dosing, Part II: Rethinking Dose

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#Plant #secmet #natprod #ChemSky

Ashwagandha Dosing, Part I Is the evidence insufficient?

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#Plant #secmet #natprod #ChemSky

Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering Covering: up to 2025. Non-ribosomal peptide synthetases and polyketide synthases are modular biosynthetic systems that produce structurally diverse and pharmacologically potent natural products,…

Be sure to read this review by Kenan Bozhüyük & co. @helmholtzhips.bsky.social highlighting the tools and strategies for NRPS and PKS pathway exploration and engineering in our latest issue #natprod #secmet

Find the full article below👇

🔓Don't miss the #OpenAccess Highlight behind the cover of our latest issue by Francesco Del Carratore & Rainer Breitling @liverpooluni.bsky.social & @manchester.ac.uk on how microbiomes can be engineered for natural product discovery and production #secmet #natprod

pubs.rsc.org/en/content/a...

Fermentation as an Extraction Method Recovering Traditional Techniques for Today's Herbal Product Needs

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#Plant #secmet #natprod #ChemSky

Does Changing Form Alter the Clinical Uses of Medicinal Plants Red Clover Extraction, Stability, Absorption, and Clinical Endpoint

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#Plant #secmet #natprod #ChemSky

📢Our latest issue is now online!

This month's issue is a special themed collection on Microbial Host & Metabolic Engineering for Natural Product Discovery & Production #secmet #natprod #chemsky

Read the articles in the collection on our website here🔽
pubs.rsc.org/en/journals/...

Overview of the paper in cartoon form

We are delighted to share our vision in #RSCChemBioy of how to incorporate natural product discovery (and any drug discovery) into the framework of personalized medicine - drug discovery using patients, but not in patients! #natprod #secmet pubs.rsc.org/en/content/a...

Engineering class I terpene synthases for skeletal diversity: strategies and applications Covering: up to August 2025 Terpenoids constitute nature's largest and most structurally diverse class of natural products, with extensive applications in medicine, agriculture, and fragrance…

Don't miss a review by Liao-Bin Dong & co. at the China Pharmaceutical University in our latest issue examining the strategies and applications for engineering class I terpene synthases for skeletal diversity #natprod #secmet

Check out the full article on our website🔽

An integrative chemical and genomic similarity approach linking fungal secondary metabolites and biosynthetic gene clusters Fungi are well known to biosynthesize structurally complex secondary metabolites (SMs) with diverse bioactivities. These fungal SMs are frequently produced by biosynthetic gene clusters (BGCs).…

Read in our latest issue a paper by @rokaslab.bsky.social & co. from @vanderbilt.edu & @uncg.edu describing an integrative chemical & genomic similarity approach to link fungal secondary metabolites & biosynthetic gene clusters #natprod #secmet

Find it in full here🔽

Glycosylated mycotoxins: a hidden enemy Covering: 2010 up to 2025 (May) Mycotoxins, secondary metabolites produced by filamentous fungi, are highly toxic contaminants of food crops. These contaminated plants pose a significant health risk…

🔓Check out this #OpenAccess review in our latest issue by Vladimír Křen & co. @vschtpraha.bsky.social & @mbuavcr.bsky.social summarising the formation and occurrence of glycosylated mycotoxins and their transformations in the food chain #natprod

Read it in full here👇

#natprod

Cardiac glycosides: structural diversity, chemical ecology, bioactivity, and artificial synthesis Covering: up to 2025 Cardiac glycosides (CGs), a class of metabolites found in nature, comprise sugar residues, unsaturated lactone rings, and steroidal cores. As renowned phytotoxins, they play…

Take a look at a review by Shuang Liu, Ping Su, Luqi Huang & co. in our latest issue providing an overview of the structural diversity, chemical ecology, bioactivity & artificial synthesis of cardiac glycosides #natprod #secmet

📍China Academy of Chinese Medical Sciences

Progress, challenges, and opportunities in the field of biosynthetic reactions involving ambimodal transition states Covering: up to June 2025 High selectivity is generally observed in the biosynthesis of complex natural molecules. Evolution usually leads to enzymes that favor the formation of a particular isomer…

Be sure to read this Highlight from Hidayat Hussain & co. at @uclacb.bsky.social & @ljmuofficial.bsky.social discussing the progress, challenges & opportunities in the field of biosynthetic reactions involving ambimodal transition states #natprod

Find in full here🔽