From diet to defence: ingestion, sequestration, biotransformation, and therapeutic potential of natural products in nudibranch predator–prey interactions Covering: 1975 up to September 2025 Nudibranchs have attracted significant interest from natural product researchers due to their intriguing predator–prey interactions and numerous bioactive met...

Check out this review by Lauren Gris & Michèle R. Prinsep @waikatouniversity.bsky.social in our latest issue focused on the nudibranch predator–prey natural products chemoecological interactions #natprod #chemicalecology

Read it in full below👇
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⏳There's less than two weeks until the poster abstract deadline for Directing Biosynthesis VIII #secmet #natprod

❗Don't miss your chance to present your latest research at the conference!🔽

Discovery, engineering, and applications of amino acid and peptide prenyltransferases Covering: up to 2025 Amino acid and peptide prenylation leads to a large variety of natural products, including neurotoxins, alkaloids and (non-)ribosomal peptides, with potent bioactivities. The key…

🔓Be sure to read this #OpenAccess Highlight by Florian Hubrich @hubrichlab.bsky.social @helmholtzhips.bsky.social discussing the discovery, engineering and applications of amino acid & peptide prenyltransferases #natprod #secmet

Find it in full on our website🔽

Don't miss the review behind the inside front cover of our latest issue by Hidayat Hussain et al. @ljmuofficial.bsky.social @czechacademy.bsky.social & @cam.ac.uk looking at the structural diversity, biosynthesis & synthesis of trimeric natural products #natprod #secmet

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📢Our latest issue is now online!

Check out the review behind the cover by Hongzhi Tang, Linquan Bai, Sang Yup Lee, Yaojun Tong & co. at Shanghai Jiao Tong University summarising recent progress in the discovery & applications of halogenases and dehalogenases #natprod

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Hot off the Press A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as candindole A from Aspergillus…

🔥Check out the first Hot off the Press article of 2026 by Robert Hill & @andysuth14.bsky.social at @uofgchem.bsky.social on their selection of 32 recent papers covering the latest research in bioorganic chemistry & novel natural products #naturalproducts #natprod

Synthetic biology for heterologous expression and engineering of fungal polyketide synthases Covering: up to 2025Polyketide synthases (PKSs) are essential enzymatic systems that produce a wide range of natural products. Their biosynthetic features offer significant opportunities to create a…

🔓Take a look at this #OpenAccess Highlight article from Pablo Cruz-Morales & co. @wemakemolecules.bsky.social discussing synthetic biology for heterologous expression and engineering of fungal polyketide synthases #secmet #natprod

📍 @dtu.dk

Streptomyces as a versatile host platform for heterologous production of microbial natural products Focus on 2004 to 2024 The rediscovery of natural products (NPs) as a critical source of new therapeutics has been greatly advanced by the development of heterologous expression platforms for…

🔓Be sure to read in our latest issue this #OpenAccess review by Andriy Luzhetskyy & co. @uni-saarland.de examining the use of Streptomyces as a versatile host platform for heterologous production of microbial natural products #secmet #natprod

Find the full article here🔽

Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we…

🔓Don't miss this #OpenAccess Viewpoint by @philmuslab.bsky.social & co. discussing the challenges & solutions to unlocking the potential of cyanobacteria in drug discovery #secmet #natprod

Check it out in full below👇

Accelerating enzyme discovery and engineering with high-throughput screening Covering: up to August 2024 Enzymes play an essential role in synthesizing value-added chemicals with high specificity and selectivity. Since enzymes utilize substrates derived from renewable…

🔓Check out the #OpenAccess review by @pabnik.bsky.social & co. @labnikel.bsky.social in our latest issue exploring emergent strategies and methods for isolating, creating & characterizing enzymes optimized for bioproduction #natprod

Read in full on our website🔽

🎉We are delighted to announce that the 2026 Natural Product Reports Emerging Investigator Lectureship has been awarded to Jakob Franke (@unihannover.bsky.social)

Please join us in congratulating him! #chemsky #natprod #secmet

Read more about Jakob and his research🔽
blogs.rsc.org/np/2026/03/1...

Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we…

🔓Take a look in our latest issue at this #OpenAccess review by Stephanie Heard & Alessandra Eustaquio @eustaquiolab.bsky.social looking at the development of Burkholderia bacteria as heterologous hosts #natprod #secmet

📍 @uofilsystem.bsky.social
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Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering Covering: up to 2025. Non-ribosomal peptide synthetases and polyketide synthases are modular biosynthetic systems that produce structurally diverse and pharmacologically potent natural products,…

Be sure to read this review by Kenan Bozhüyük & co. @helmholtzhips.bsky.social highlighting the tools and strategies for NRPS and PKS pathway exploration and engineering in our latest issue #natprod #secmet

Find the full article below👇

🔓Don't miss the #OpenAccess Highlight behind the cover of our latest issue by Francesco Del Carratore & Rainer Breitling @liverpooluni.bsky.social & @manchester.ac.uk on how microbiomes can be engineered for natural product discovery and production #secmet #natprod

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Editorial: Microbial host and metabolic engineering for natural product discovery and production Alessandra Eustaquio, Eriko Takano and Tobias Gulder introduce the Natural Product Reports themed issue on microbial host and metabolic engineering for natural product discovery and production.

Check out the Editorial from guest editors Alessandra Eustaquio @eustaquiolab.bsky.social, Eriko Takano & Tobias Gulder @togulab.bsky.social on how the articles in the issue cover various topics enabling microbial natural product discovery, supply and engineering

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📢Our latest issue is now online!

This month's issue is a special themed collection on Microbial Host & Metabolic Engineering for Natural Product Discovery & Production #secmet #natprod #chemsky

Read the articles in the collection on our website here🔽
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Engineering class I terpene synthases for skeletal diversity: strategies and applications Covering: up to August 2025 Terpenoids constitute nature's largest and most structurally diverse class of natural products, with extensive applications in medicine, agriculture, and fragrance…

Don't miss a review by Liao-Bin Dong & co. at the China Pharmaceutical University in our latest issue examining the strategies and applications for engineering class I terpene synthases for skeletal diversity #natprod #secmet

Check out the full article on our website🔽

Glycosylated mycotoxins: a hidden enemy Covering: 2010 up to 2025 (May) Mycotoxins, secondary metabolites produced by filamentous fungi, are highly toxic contaminants of food crops. These contaminated plants pose a significant health risk…

🔓Check out this #OpenAccess review in our latest issue by Vladimír Křen & co. @vschtpraha.bsky.social & @mbuavcr.bsky.social summarising the formation and occurrence of glycosylated mycotoxins and their transformations in the food chain #natprod

Read it in full here👇

Cardiac glycosides: structural diversity, chemical ecology, bioactivity, and artificial synthesis Covering: up to 2025 Cardiac glycosides (CGs), a class of metabolites found in nature, comprise sugar residues, unsaturated lactone rings, and steroidal cores. As renowned phytotoxins, they play…

Take a look at a review by Shuang Liu, Ping Su, Luqi Huang & co. in our latest issue providing an overview of the structural diversity, chemical ecology, bioactivity & artificial synthesis of cardiac glycosides #natprod #secmet

📍China Academy of Chinese Medical Sciences

Progress, challenges, and opportunities in the field of biosynthetic reactions involving ambimodal transition states Covering: up to June 2025 High selectivity is generally observed in the biosynthesis of complex natural molecules. Evolution usually leads to enzymes that favor the formation of a particular isomer…

Be sure to read this Highlight from Hidayat Hussain & co. at @uclacb.bsky.social & @ljmuofficial.bsky.social discussing the progress, challenges & opportunities in the field of biosynthetic reactions involving ambimodal transition states #natprod

Find in full here🔽

Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis Covering: 1948 to 2025 Ryanodane diterpenes (RDs) are a unique class of plant-derived natural products characterized by their complex, polyoxygenated pentacyclic frameworks. They have been primarily…

Don't miss this review in our latest issue by Yu Zhang et al. from the Kunming Institute of Botany looking at the occurrence, structural diversity, bioactivities and synthesis of ryanodane diterpenes #natprod #secmet

Check out the full article below👇

📢Our annual Marine Natural Reports review is in our latest issue and #OpenAccess! #chemsky #natprod #secmet

A big thank you to the authors:
Tony Carroll, Brent Copp, Tanja Grkovic, Robert Keyzers & Michèle Prinsep

Read their coverage of the 2024 MNP literature here🔽
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🎉We are delighted to welcome @kelloggnpgroup.bsky.social, @kateduncan.bsky.social & Yihua Chen to the @natprodreports.rsc.org Editorial Board! #natprod #secmet

Learn more about our new Editorial Board members here🔽
blogs.rsc.org/np/2026/01/3...

📢Our first issue of 2026 is now online!

Check out the review behind the cover by Mark Butler, Robert Capon & co. at the University of Queensland covering natural product-derived compounds in clinical trials & drug approvals from 2014-2024 #natprod #secmet #medchem

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Rotenoid diversity, distribution and evolution in plant lineages Covering upto 2025 Rotenoids are angular hybrid isoflavonoids mainly characterized by an additional six-membered ring between the B and C rings of flavonoids. The extra ring introduces further…

Read this Highlight in our latest issue by Vaderament-A. Nchiozem-Ngnitedem, Gabin Thierry M. Bitchagno et al. from @unipotsdam.bsky.social & @rbgkew.bsky.social discussing Rotenoid diversity, distribution and evolution in plant lineages #natprod

Find in full here👇

Don't miss your chance to present your research at Directing Biosynthesis VIII!

⏳Time is running out until the oral abstract deadline on the 2nd of February▶️ rsc.li/dbviii

Be sure to join us and the rest of the #Biosynthesis community in Manchester this summer

#natprod #secmet #DBVIII

Discovery, biosynthesis, and bioactivities of peptidic natural products from marine sponges and sponge-associated bacteria Covering 2010 to 2025 Sponges are benthic, sessile invertebrate metazoans that are some of the most prolific sources of natural products in the marine environment. Sponge-derived natural products are…

🔓Don't miss this #OpenAccess review by Eric W. Schmidt, Vinayak Agarwal & co. at @utah.edu & @gtsciences.bsky.social looking at peptidic natural products isolated from the sponge hosts and the associated microbiome #natprod #secmet

Check it out in full on our website🔽

Structures, biosynthetic pathways, and biological significance of bacterial aryl-heterocycle metallophores with emphasis on yersiniabactin-type derivatives Covering: up to 2025 Metallophores are metal-chelating natural products produced by microorganisms to scavenge essential metal ions in nutrient-limited environments. Among them, yersiniabactin-type…

Check out this review by Christine Beemelmanns & co. at @cbeemelmanns.bsky.social & @helmholtzhips.bsky.social in our latest issue focused on the structural, biosynthetic, and genomic features of yersiniabactin-type metallophores #natprod #secmet

Read in full below👇

Hot off the Press A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as humulupone A from Humulus lupulus.

🔥Take a look at the last Hot off the Press article of 2025 by Robert Hill & @andysuth14.bsky.social on their selection of 32 recent papers covering the latest research in bioorganic chemistry & novel natural products #naturalproducts #natprod

📍 @uofgchem.bsky.social

The oxidative rearrangements in bacterial aromatic polyketide biosynthesis Covering: up to April 2025 Bacterial aromatic polyketides represent a notable class of natural products that have found extensive applications in clinical treatments. In their biosynthesis, oxid...

Be sure to read in our latest issue this review by Hongzhi Qiao, Ruihua Jiao et al. from Nanjing University of Chinese Medicine discussing how redox chemistry is used by enzymes in bacterial aromatic polyketide biosynthesis #natprod #secmet

Find in full here🔽
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