Epstein-Barr virus infection is causally associated with idiopathic pulmonary fibrosis: a bidirectional Mendelian randomization study Introduction: Previous studies suggest an association between herpes virus infections and idiopathic pulmonary fibrosis (IPF), but the causal relationship remains largely unclear. We used bidirection...

#antibody #idiopathicpulmonaryfibrosis #Mendelianrandomization #herpesvirus #infection

www.archivesofmedicalscience.com/Epstein-Barr...

In @jem.org, Klepper et al. show that patients with #autoimmune #hepatitis have a unique autoantibody signature, incl. evidence for cross-reactivity with a common #herpesvirus & antibodies targeting the antifibrotic relaxin receptor with potential to promote #fibrosis rupress.org/jem/article/...

Klepper, Tana, DeRisi et al. show that patients with #autoimmune #hepatitis have a unique autoantibody signature, incl. evidence for cross-reactivity with a common #herpesvirus & antibodies targeting the antifibrotic relaxin receptor with potential to promote #fibrosis rupress.org/jem/article/...

Release of herpes virus into waterways to fight carp delayed Release of a virus to control carp in Australian waterways has been delayed until 2028, a decade after it was initially slated for release.

Release of herpes virus into waterways to fight carp delayed #carp #nationalcarpcontrolplan #herpesvirus

🚨 New Issue Alert! 🚨

We're delighted to share that the fourth issue of The FEBS Journal is now online.

Discover our latest Issue, here ➡️ buff.ly/5wZasfQ

#macrophage #ferroptosis #machinelearning #herpesvirus #platelet

Extended poly(A) tails are a shared feature of herpesvirus mRNAs Poly(A) tails are present on most cellular and viral mRNAs, providing a platform for poly(A)-binding proteins that stimulate translation and regulate the deadenylation and stability of transcripts in the cytoplasm. Here we leverage nanopore direct RNA sequencing to analyse the distribution of poly(A) tail lengths on cellular and viral mRNAs across Herpesviridae and other DNA and RNA virus infections. We find that herpesvirus mRNA poly(A) tails are consistently longer than those on cellular and other viral transcripts, presenting a previously unrecognized yet widespread mechanism to advantage herpesviral gene expression. This contrasts with the templated poly(A) tails on coronavirus RNAs and those on cytoplasmically transcribed poxviral mRNAs, which are more similar in length to those on host mRNAs. Herpesviral noncoding RNAs display differential poly(A) tailing patterns which do not correlate with nuclear localisation while individual herpesviral mRNAs also show variation in the extent to which their poly(A) tail lengths change during the virus lifecycle, suggestive of additional uncharacterised layers of poly(A) tail length regulation. Importantly, while we detect non-adenosine nucleotides within herpesviral poly(A) tails, which are known to oppose deadenylase activity, this “mixed tailing” is not at sufficient frequency to explain the widespread extended tails of herpesvirus mRNAs. ### Competing Interest Statement The authors have declared no competing interest.

New preprint finds extended poly(A) tails are a shared feature of #herpesvirus mRNAs, suggesting conserved post-transcriptional regulation across herpesviruses and potential impacts on translation and stability. 🧬📄 #Virology
📄 https://doi.org/10.64898/2025.12.15.694445
👤 EVBC member: Daniel Depledge

A mother in the United Kingdom said doctors first thought her 16-month-old son, Juwon, had a simple eye infection when his symptoms began in August 2024.

#HealthNews #UKNews #ChildHealth #MedicalAwareness #EyeHealth #HerpesVirus

First ancient human herpesvirus genomes document their deep history with humans For the first time, scientists have reconstructed ancient genomes of Human betaherpesvirus 6A and 6B (HHV-6A/B) from archaeological human remains more than two millennia old. The study, led by the…

First ancient human #herpesvirus #genomes document their deep #history with #humans ...

| #Archaeology | #virus | #DNA | By @univie.ac.at via eurekalert .org

Mechanisms of HSV-1 Helicase-Primase Inhibition  Highlights • Structures of HSV-1 helicase-primase and replication fork complexes determined • Inhibitors cause the helicase-primase complex to pause on DNA • Conserved polymerase FYNPYL motif interacts with viral helicase • Structures inform mechanisms of drug selectivity and targeting   Summary Herpesviruses are widespread double-stranded DNA viruses that establish lifelong latency and cause various diseases. Although DNA-polymerase-targeting antivirals are effective, increasing drug resistance underscores the need for alternatives. Helicase-primase inhibitors (HPIs) are promising antivirals, but their mechanisms of action are poorly defined. Furthermore, how the helicase-primase (H/P) complex and DNA polymerase coordinate genome replication is not well understood for herpesviruses. Here, we report cryo-electron microscopy (cryo-EM) structures of the herpes simplex virus 1 H/P complex bound to HPIs, showing that these lock the H/P complex in an inactive state. Single-molecule assays reveal that HPIs cause H/P complexes to pause in unwinding activity on DNA. The structure of an HPI-bound replication fork complex, comprising the H/P complex (UL5, UL52, and UL8) and the polymerase holoenzyme (UL30 and UL42), reveals a previously uncharacterized interface bridging these complexes. These findings provide a structural framework for understanding herpesvirus replisome assembly and advancing inhibitor development.   Published in Cell (December): https://www.cell.com/cell/fulltext/S0092-8674(25)01376-5   

A new study published in Cell describes with precise detail the mode of action of helicase-primase inhibitors (HPIs) targeting HSV-1 #HSV #herpesvirus

I'm a complete layman when it comes to scientific matters, but that's why I'm allowed to say the following:

I believe we will be reading much more about these viruses in the future (cause and/or trigger for "unexplained" diseases?).
#HHV6 Humanes #Herpesvirus 6

New Paper ⬇️

How is herpes simplex virus type 2 transmitted?

In sixth place - Herpes simplex virus type 2
Herpes simplex virus type 2 is transmitted almost exclusively through intimate relations. Is responsible for genital herpes.

#herpessimplex #herpesvirus #Herpessimplex2 #genitalherpes

Epstein-Barr virus (EBV) is a common human #herpesvirus that typically spreads through saliva and is known for causing infectious mononucleosis (i.e., “mono”). There is an established causal link between infection with EBV and the development of multiple sclerosis. 2/

What is cytomegalovirus?

On the 8th place - Cytomegalovirus
Cytomegalovirus is also a member of the Herpesviridae family.
It is also called human herpesvirus type 5.

#cytomegalovirus #herpesvirus #Cytomegalovirusherpesvirus #Cytomegalovirusinfection

Last week, Gregory lab #PhD student Emma Hatchell attended @sfn.org #Sfn2025 in beautiful San Diego and presented a poster!

"Spatial Profiling of #Herpesvirus Transcripts in #MultipleSclerosis Spinal Cord Lesions Using #Xenium In Situ Analysis" 🧬

Equine Herpesvirus shuts down Bastrop rodeo arena The City of Bastrop announced that the Mayfest Park Rodeo Arena would be closed until further notice after the Equine Disease Communication Center recommended the closure due to Equine Herpesvirus …

#Equine #Herpesvirus shuts down #rodeo arena ...

| #Myeloencephalopathy | #virus | #outbreak | #horses | Via @kxan.com

Equine Herpesvirus outbreak alert issued to Texas horsemen after event in Central Texas Commissioner Miller says he is urging all horse owners, trainers, and venue operators in the area to act swiftly

#Equine #Herpesvirus outbreak alert issued to #Texas horsemen after event in #CentralTexas share.google/h7INSvDmEQ7D...

New Herpesvirus Treatment For Cats?!
🎥Watch the full video here 👉https://youtu.be/yNAGdlACZSY
#cat #cats #catsofinstagram #meow #animal #animals #pet #pets #petsofinstagram #petcare #petlovers #petlife #herpesvirus

Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.

We're only beginning to understand the relationship between the immune system and lifelong infection w/ #herpesvirus #EBV
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...

Don't miss out on todays talk at the virtual Herpes-V 2025 conference. Irene is talking about the HCMV genetic diversity in vivo and in vitro. You can still register!

#HerpesV2025 #herpesvirus #humancytomegalovirus #conference

New study from Werner, Mogensen et al. @au.dk this study identifies genetically heterozygous but transcriptionally homozygous IRF7 deficiency as #InbornErrorsOfImmunity underlying #herpesvirus central nervous system infection. rupress.org/jem/article/...

#HumanDiseaseGenetics #Immunodeficiency

#Medsky🧪 #IDsky #immunosky #publichealth This study identifies genetically heterozygous but transcriptionally homozygous IRF7 deficiency as an IEI underlying #herpesvirus - CNS infection.

www.researchgate.net/publication/...

omim.org/entry/605047....

www.pnas.org/doi/10.1073/...

Werner, Mogensen et al. @au.dk identify genetically heterozygous and transcriptionally homozygous deficiency of IRF7 as an inborn error of interferon immunity underlying #herpesvirus CNS infection. rupress.org/jem/article/...

#HumanDiseaseGenetics #Immunodeficiency #InfectiousDisease #HostDefense

In @jem.org, Werner, Mogensen et al. @au.dk identify genetically heterozygous and transcriptionally homozygous deficiency of IRF7 as an inborn error of interferon immunity underlying #herpesvirus CNS infection. rupress.org/jem/article/...

#HumanDiseaseGenetics #Immunodeficiency #InfectiousDisease

#ExM #3DSTED for #fluorescencefriday:
#herpesvirus particles 4-5x expanded. Viral glycoprotein (🟨STAR RED) and tegument protein (🟦STAR 580) stained.
Don’t just expand your sample, expand your options with abberior dyes and STED!
Sample courtesy: Jannik Jensen & @bosse-lab.bsky.social
#virology

Understanding How a Common Virus Manipulates Host DNA - News Center Northwestern Medicine scientists have discovered how a common virus linked to birth defects and chronic illness manipulates host DNA, according to a new study published in Nature Communications.

Understanding how a common virus manipulates its host's DNA

(Human #cytomegalovirus #HCMV is known to be linked to birth defects and chronic illness)

#virology #herpesvirus #chromatin

Breakthrough results from elephant herpesvirus trial find vaccine to be safe | University of Surrey

Results from elephant herpesvirus trial find vaccine to be safe

"The world’s first vaccine trial against elephant endotheliotropic #herpesvirus (EEHV) – a leading cause of death in young Asian #elephants – is safe & triggers a strong virus-fighting immune response"

www.surrey.ac.uk/news/breakth...

Understanding How a Common Virus Manipulates Host DNA - News Center Northwestern Medicine scientists have discovered how a common virus linked to birth defects and chronic illness manipulates host DNA, according to a new study published in Nature Communications.

Understanding how a common virus manipulates its host's DNA

(Human #cytomegalovirus #HCMV is known to be linked to birth defects and chronic illness)

#virology #herpesvirus #chromatin

Rapid glycoprotein evolution enables variant interactions in herpes simplex virus type 1 Abstract. Glycoproteins cover the surface of enveloped viruses such as herpes simplex virus 1 (HSV-1). Whilst essential for cellular attachment and entry,

New paper alert 🚨
Check out our latest article about #social interactions in #herpesvirus populations via #glycoprotein variants, now in @Virus_Evolution. Thanks to everyone involved, also to the very supportive reviewers who definitely improved the manuscript!
academic.oup.com/ve/article/1...

Breakthrough results from elephant herpesvirus trial find vaccine to be safe The world’s first vaccine trial against elephant endotheliotropic herpesvirus (EEHV) – a leading cause of death in young Asian elephants – is safe and triggers a strong virus-fighting immune response, according to an international team led by the University of Surrey, Chester Zoo and the Animal and Plant Health Agency.

3-Oct-2025
Breakthrough results from #elephant #herpesvirus trial find #vaccine to be safe

https://www.eurekalert.org/news-releases/1100443

#science #animals #veterinarian

“Bench to Barn” Effort Protects Baby Elephants from a Deadly Virus Learn about the innovative mRNA vaccine against elephant endotheliotropic herpesvirus, aiming to save vulnerable baby elephants.

“Bench to Barn” effort protects baby #elephants from a deadly #virus ...

| #zoo | #vaccine | #herpesvirus | #infection | #EEHV | #hemorrhagic | Via the-scientist .com