Machine learning helps to strongly reduce future warming uncertainty - Nature Communications This study presents a machine learning-based emergent constraint that reduces uncertainty in future warming projections by ~70% by identifying land and ocean areas that are the most informative of fut...

New study presents a #MachineLearning -based emergent constraint that reduces uncertainty in future #climate #warming projections by ~70%. The constraint projections show that an earlier than anticipated exceedance of 2°C warming is more likely. www.nature.com/articles/s41...

Climate models exaggerate greenhouse gas impact on recent interhemispheric temperature patterns and tropical climate - Nature Communications Climate models overestimate greenhouse gas effects on the temperature difference between Earth’s hemispheres, with this bias strongest in high climate sensitivity models, suggesting future tropical rainfall shifts may be less severe than projected.

New study by @atmos-dynamics.bsky.social and colleagues shows that #ClimateModels overestimate greenhouse gas effects on the interhemispheric #temperature difference, suggesting future #tropical #rainfall shifts may be less severe than projected. www.nature.com/articles/s41...

🔬🤖 How can we explore chemical reactions without guessing the pathway first?

Zhang & Piccini introduce Loxodynamics: a deep‑learning approach that uses the skewness of molecular motion to automatically find reaction pathways.

www.nature.com/articles/s41...

#ScienceSky #CompChem #MachineLearning

New study shows that declining anthropogenic #aerosols can amplify the weakening of the Northern Hemisphere #HadleyCirculation, highlighting the critical role of aerosol reductions in driving #TropicalCirculation changes in the 21st century. www.nature.com/articles/s41...

New study shows that a transition of the #stratospheric polar vortex morphology is an effective precursor of the phase reversal of the “warm Arctic-cold Eurasia” pattern in winter and that #CMIP6 models with complete stratospheric processes can capture this link. www.nature.com/articles/s41...

Chromosome-specific telomere lengths measured in >2,500 All of Us participants reveal arm‑level variation, strong individual differences, and age‑related shortening. #LongReadSequencing enables refined disease‑association analyses. #NatureCommunications #Genetics
Read more below 🔗

Ecological partitioning enables phage–antibiotic cooperation in a human Pseudomonas infection - Nature Communications This case report presents a multi-omics case analysis of intravenous phage-antibiotic co-therapy in a patient with cystic fibrosis during an acute-on-chronic pulmonary exacerbation caused by multidrug-resistant Pseudomonas aeruginosa.

Ecological partitioning enables phage–antibiotic cooperation in a human Pseudomonas infection

#Antibiotics & #PhageTherapy coordinate through ecological & immunologic complementarity rather than direct pharmacologic synergy

@scientiff.bsky.social

Acinetobacter baumannii’s lifestyle includes soil-dwelling colonization of decaying plant material and airborne spread - Nature Communications Little is known about the ecology and evolution of the nosocomial pathogen Acinetobacter baumannii outside the hospital. Here, Wilharm et al. show that the lifestyle of A. baumannii includes soil-dwelling and airborne dissemination, which helps to explain its adaptability and predisposition to establish within hospitals.

Ecology and evolution of the nosocomial pathogen Acinetobacter baumannii outside hospital settings:

- soil-dwelling colonization of decaying plant material

- airborne dissemination

@rki.de #Acinetobacter #infection #MicrobialEcology

Pathogenic variants in the cohesin loader subunit MAU2 underlie a distinct Cornelia de Lange Syndrome subtype - Nature Communications MAU2’s role in Cornelia de Lange syndrome was unclear. Here, the authors identify pathogenic MAU2 variants that disrupt NIPBL–MAU2 function, define MAU2‑specific episignatures, and show variable CdLS‑related phenotypes, supported by a Mau2 knockout mouse model.

MAU2 variants define a distinct CdLS subtype 🧬 In 18 individuals, 15 heterozygous variants disrupt MAU2–NIPBL function, show MAU2‑specific episignatures, and are validated in a Mau2 knockout mouse model 🐁 Read more:

Amazon deforestation weakens Atlantic Niño variability - Nature Communications This study shows that extensive deforestation in the Amazon Basin has contributed substantially to the observed weakening of the Atlantic Niño variability since 1970, by strengthening the cross-equato...

New study shows that #deforestation in the #Amazon Basin has contributed substantially to the observed weakening of the #Atlantic Niño variability since 1970. www.nature.com/articles/s41...

Dolutegravir restores gut microbiota in late-stage HIV-1 unlike darunavir: an open-label, randomized clinical trial - Nature Communications Advanced HIV-1 infection is associated with gut dysbiosis, and it’s not known whether this is reversed with antiviral therapy. The ADVANZ-4 MISTRAL trial shows that dolutegravir restores gut microbiota in late-stage HIV1 patients better than darunavir, and that recovery is linked to improved immune reconstitution.

Clinical trial: dolutegravir restores gut microbiota in late-stage HIV-1 patients better than darunavir, linked to improved immune reconstitution

@rutgerwalls.bsky.social @fcatalamoll.bsky.social @irsicaixa.es @hospitalclinic.bsky.social

Acinetobacter baumannii’s lifestyle includes soil-dwelling colonization of decaying plant material and airborne spread - Nature Communications Little is known about the ecology and evolution of the nosocomial pathogen Acinetobacter baumannii outside the hospital. Here, Wilharm et al. show that the lifestyle of A. baumannii includes soil-dwelling and airborne dissemination, which helps to explain its adaptability and predisposition to establish within hospitals.

Ecology and evolution of the nosocomial pathogen Acinetobacter baumannii outside hospital settings:

- soil-dwelling colonization of decaying plant material

- airborne dissemination

@rki.de #Acinetobacter #infection #MicrobialEcology

Tropical volcanism triggers pan-Asian monsoon droughts via circumglobal teleconnection - Nature Communications This study shows that explosive tropical volcanic eruptions can trigger pan-Asian monsoon droughts by initiating a circumglobal teleconnection, providing evidence of how volcanic forcing can affect hy...

New study shows that explosive tropical #volcanic #eruptions can trigger pan-Asian #monsoon #droughts by initiating a circumglobal teleconnection, providing evidence of how volcanic forcing can affect #hydroclimate across #Asia. www.nature.com/articles/s41...

FOXA1 loss in mice shown to drive basal-squamous de-differentiation and to remodel the tumor microenvironment in prostate cancer doi.org/10.1038/s414...

Dolutegravir restores gut microbiota in late-stage HIV-1 unlike darunavir: an open-label, randomized clinical trial - Nature Communications Advanced HIV-1 infection is associated with gut dysbiosis, and it’s not known whether this is reversed with antiviral therapy. The ADVANZ-4 MISTRAL trial shows that dolutegravir restores gut microbiota in late-stage HIV1 patients better than darunavir, and that recovery is linked to improved immune reconstitution.

Clinical trial: dolutegravir restores gut microbiota in late-stage HIV-1 patients better than darunavir, linked to improved immune reconstitution

@rutgerwalls.bsky.social @fcatalamoll.bsky.social @irsicaixa.es @hospitalclinic.bsky.social

Gaps and ways forward in atmospheric blocking and extreme weather research - Nature Communications Atmospheric blocking often causes weather extremes in the mid- to high latitudes, yet the physical processes underlying blocks are not well understood. This article provides an overview, identifies cu...

New perspective piece by Lei Wang (@leiwqg.bsky.social) and colleagues discusses current knowledge gaps and challenges in #atmospheric #blocking and extreme #weather research, offering recommendations on potential ways forward. @usclivar.bsky.social www.nature.com/articles/s41...

Ecological partitioning enables phage–antibiotic cooperation in a human Pseudomonas infection - Nature Communications This case report presents a multi-omics case analysis of intravenous phage-antibiotic co-therapy in a patient with cystic fibrosis during an acute-on-chronic pulmonary exacerbation caused by multidrug-resistant Pseudomonas aeruginosa.

Ecological partitioning enables phage–antibiotic cooperation in a human Pseudomonas infection

#Antibiotics & #PhageTherapy coordinate through ecological & immunologic complementarity rather than direct pharmacologic synergy

@scientiff.bsky.social

Snow or rain? hybrid AI deciphers surface precipitation phase from satellite observations - Nature Communications Distinguishing surface rain from snow in real time is crucial for winter storm warnings. This study presents “RePPIC-Net”, a hybrid AI model that fuses satellite data with AI weather forecasts to deci...

New study presents “RePPIC-Net”, a hybrid #AI model that fuses #satellite data with AI #weather forecasts to decipher #snow from #rain with rapid speed and accuracy, paving the way for improved global #hazard alerts. www.nature.com/articles/s41...

Researchers Uncover Hidden Genetic World in Antarctic Waters The discovery of vast numbers of previously unknown microbial genes in Antarctic waters could improve understanding of how the ocean shapes Earth’s climate.

Researchers Uncover Hidden Genetic World in Antarctic Waters

"at least a third of the genes identified are missing from existing marine gene catalogs"

@loimai.bsky.social #microbiome #oceans

Convergent extreme reductive evolution in ancient planthopper symbioses - Nature Communications Symbiotic bacteria can have exceedingly small genomes. This study finds that ancient bacterial symbionts of planthoppers have repeatedly evolved the smallest known genomes, losing most biosynthetic fu...

Our paper is now out in its final form in @natcomms.nature.com ! We show that ancient insect symbionts can undergo extreme, convergent genome reduction to as little as ~50 kb - driven by ecological shifts and symbiont replacement.

🔗 www.nature.com/articles/s41...

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Logo for Nature Progress Oncology

Announcing Nature Progress Oncology! An open-access journal in the new Nature Progress series, publishing significant advances in cancer research, from cell biology and immunology, therapeutics, clinical research, and epidemiology

nature.com/natprogoncology

Silencing bacteria can worsen heart infections: Study Is blocking bacterial communication always beneficial? A team from the University of Geneva (UNIGE) and Nanyang Technological University, Singapore (NTU Singapore) challenges a widely held assumption in infectious disease research.

Silencing bacteria can worsen heart infections

In infectious disease research, disrupting bacterial communication is widely considered beneficial. A study by UNIGE & NTU Singapore shows this is not always true

Prenatal Zika virus exposure disrupts social-emotional development and cortical visual function in infant macaques - Nature Communications Prenatal Zika virus (ZIKV) exposure can lead to a spectrum of developmental issues, but the mechanisms remain unclear. Here the authors show that prenatal ZIKV exposure in macaques disrupts neurodevelopment, causing prolonged maternal attachment and visual deficits at 3 months that normalize by 12 months, independent of sensory function.

#Virology

Prenatal exposure to #Zika virus disrupts social-emotional development and cortical visual function in infant macaques

@mohrlab.bsky.social

Loss of Fsr quorum sensing promotes biofilm formation and worsens outcomes in enterococcal infective endocarditis - Nature Communications Infective endocarditis (IE) is an understudied biofilm-associated infection. Here, analyses of preclinical and clinical data reveal that the Fsr quorum sensing (QS) system of Enterococcus faecalis is a negative regulator of IE pathogenesis.

#Microbiology

Loss of Fsr quorum sensing *promotes* biofilm formation and worsens outcomes in enterococcal infective endocarditis

@kimingeneva.bsky.social @harisantypas.bsky.social @scelse.bsky.social

#biofilms #bacteria

Logo for Nature Progress Brain Health

Announcing Nature Progress Brain Health! A new open-access journal bringing together timely research across the full landscape of brain health, including preclinical and translational neuroscience, neurology, and neuropsychiatry

nature.com/natprogbrainhealth

New study shows that #ENSO phase transition enhances the #predictability of the winter North Atlantic Oscillation ( #NAO) one year ahead through atmospheric angular momentum dynamics, improving long-range #climate forecasts. www.nature.com/articles/s41...

CO2 radiative forcing induces summer cooling over India - Nature Communications Rising atmospheric CO2 concentrations can paradoxically induce summer surface cooling over India. This is happening via an atmospheric dynamical pathway, wherein enhanced Eurasian warming increases cl...

New study sheds light on the drivers of summer #cooling ( #WarmingHole) over #India under greenhouse gas warming. Via an #atmospheric pathway, enhanced Eurasian warming increases #cloud cover and reduces solar radiation, leading to this regional cooling. www.nature.com/articles/s41...

Associations of #sleep characteristics with lifestyle factors and gut #microbiome composition in a cohort of over 6,900 participants

Contrary effects of soil moisture-atmosphere feedback on dry and humid heatwaves - Nature Communications This study shows that soil moisture–atmosphere feedback (SAF) amplifies dry heatwaves but reduces the duration and severity of humid ones in low-to-mid latitudes. This contrast arises from the competi...

New study shows that #SoilMoisture – #atmosphere feedback (SAF) amplifies dry #heatwaves but reduces the duration and severity of humid ones in low-to-mid latitudes. This contrast arises from the competition between SAF-induced #warming and #moisture depletion. www.nature.com/articles/s41...

Record-breaking emergence of upstream-downstream zonal-consistent variation in the Eurasian jet axis - Nature Communications This study finds a record-breaking upstream-downstream zonal-consistent variation in the Eurasian jet axis since 1999, which is enhanced with global warming, and induces a circumglobal Silk Road telec...

New study reports a record-breaking variation in the Eurasian #JetStream axis since 1999, which is enhanced with #GlobalWarming, and induces a circumglobal Silk Road teleconnection, linking #climate extremes across the Northern Hemisphere. www.nature.com/articles/s41...