Discovery of a potent anti-#zika virus benzamide series targeting the viral protein NS4B by Donghoon Chung, Yuka Otsuka, Eunjung Kim, Sultan Ullah, Nicole M. Kennedy, Khac Huy Ngo, Jinjoo Kang, Reece Tomlinson, Brian Alejandro, Koji Barnaby, Jeffrey Miller, Justin Shumate, Chwee Fang Teo, Yaw Bia Tan, Che Shin Chew, CongBao Kang, Dahai Luo, Louis Scampavia, Timothy P. Spicer, Thomas D. Bannister Zika virus (ZIKV), a member of the Flaviviridae family, causes significant public health concerns through congenital Zika syndrome and Guillain-Barré syndrome, yet no effective anti-ZIKV drugs or vaccines are available. To address this critical need, we conducted phenotypic, cytopathic effect-based high-throughput screening followed by medicinal chemistry optimization and discovered novel benzamide anti-ZIKV leads. Current best compounds demonstrated superior potency (EC50 values 40–400 nM, CC50 > 50 µM) compared to NITD-008, the most potent known anti-ZIKV agent. Time-of-addition assays, resistant virus selection studies, and biophysical binding experiments confirmed that NS4B interference constitutes the primary antiviral mechanism. Notably, resistance mutations mapped to the C-terminus of NS4B, distinct from other flavivirus NS4B inhibitors targeting dengue or yellow fever viruses, revealing novel insights into a critical function of the region. These findings establish NS4B as an Achilles’ heel for flaviviruses and support the development of pan-flavivirus therapeutics targeting this essential viral protein.

Discovery of a potent anti-#zika virus benzamide series targeting the viral protein NS4B PLOSPathogens

🦟 Pourquoi les #moustiques transmettent-ils davantage le virus #Zika africain que le Zika asiatique ?

https://ow.ly/2M3K50YBBzY

Immune mechanisms of congenital Zika syndrome This Review discusses both fetal and maternal immune responses that influence the development of congenital Zika syndrome.

🧪 Immune mechanisms of congenital #Zika syndrome | Science Immunology www.science.org/doi/10.1126/...

Prenatal Zika virus exposure disrupts social-emotional development and cortical visual function in infant macaques - Nature Communications Prenatal Zika virus (ZIKV) exposure can lead to a spectrum of developmental issues, but the mechanisms remain unclear. Here the authors show that prenatal ZIKV exposure in macaques disrupts neurodevelopment, causing prolonged maternal attachment and visual deficits at 3 months that normalize by 12 months, independent of sensory function.

#Virology

Prenatal exposure to #Zika virus disrupts social-emotional development and cortical visual function in infant macaques

@mohrlab.bsky.social

Researchers reveal m6A epigenetic modification controls arbovirus infection and transmission between vertebrates and mosquitoes A research team led by Prof. ZHENG Aihua from the Institute of Zoology of the Chinese Academy of Sciences revealed that N6-methyladenosine (m6A) epigenetic modifications in mosquito-borne…

#m6A #epigenetic modification controls #arbovirus #infection and transmission between #vertebrates and #mosquitoes ...

| #Arthropod | #arboviruses | #dengue | #pathogen | #Zika | #MicroSky | Via eurekalert .org

Prenatal Zika virus exposure disrupts social-emotional development and cortical visual function in infant macaques - Nature Communications Prenatal Zika virus (ZIKV) exposure can lead to a spectrum of developmental issues, but the mechanisms remain unclear. Here the authors show that prenatal ZIKV exposure in macaques disrupts neurodevelopment, causing prolonged maternal attachment and visual deficits at 3 months that normalize by 12 months, independent of sensory function.

#Virology

Prenatal exposure to #Zika virus disrupts social-emotional development and cortical visual function in infant macaques

@mohrlab.bsky.social

#News: #Deforestation is making mosquitoes bite humans more! 🧐🦟 As #forests disappear, #mosquitoes lose their natural prey and target us instead, spreading diseases like #Zika and #dengue fever. 🌴☠️🚫 #BoycottPalmOil #Boycott4Wildlife @palmoildetect.bsky.social www.sciencedaily.com/releases/202...

¿Cómo atacan los mosquitos? La ciencia revela su patrón Un estudio detalla cómo decide atacar un mosquito, por qué unas personas reciben más picaduras y qué cambia con su avance en España. Los mosquitos no atacan al azar. Esa es la noticia de fondo, la que...

¿Cómo atacan los mosquitos? La ciencia revela su patrón #Mosquitos #MosquitoTigre #Dengue #SaludPublica #Ciencia #Investigacion #MIT #GeorgiaTech #VirusDelNilo #Zika #Chikunguña #Aedes #felizmiercoles #18demarzo donporque.com/como-atacan-...

🦟 🦠 Notre équipe et celle de @simonlorierelab.bsky.social
au sein du laboratoire "Génomique Évolutive, Modélisation et Santé" (GEMS) @cnrsecologie.bsky.social @pasteur.fr
avons élucidé les déterminants génétiques viraux de la transmissibilité du #virus #Zika par le #moustique Aedes aegypti

Hoffentlich wird das nicht hier übertragen,in 🇧🇷wird geimpft und trotzdem gibt's unzählige Fälle.
Das Problem der Tiger Mücke, sie überträgt noch andere Krankheiten #Zika und #Chikunguya und da gibt's keine Impfung.

Remember Zika? It didn't vanish. It's still affecting lives in Africa, So, we're demanding it get the attention it deserves. Join our #ZikaStillLivesHere campaign. Let's break the silence and make a difference. #Zika #GlobalHealth #WHO #MicrocephalyInAfrica

Forest loss is driving mosquitoes’ thirst for human blood In the rapidly disappearing Atlantic Forest, mosquitoes are adapting to a human-dominated landscape. Scientists found that many species now prefer feeding on people rather than the forest’s diverse wildlife. This behavior dramatically raises the risk of spreading dangerous viruses such as dengue and Zika. The findings reveal how deforestation can quietly reshape disease dynamics.

#News: #Deforestation is making mosquitoes bite humans more! 🧐🦟 As #forests disappear, #mosquitoes lose their natural prey and target us instead, spreading diseases like #Zika and #dengue fever. 🌴☠️🚫 #BoycottPalmOil #Boycott4Wildlife @palmoildetect.bsky.social www.sciencedaily.com/releases/202...

For senior neuroscience major Clara Abdelmalek, a scholarship enabled her to focus on her research studying prenatal #Zika infection.

#GivingDayUMD is your chance to support #ScienceTerps like Clara. Pick a fund close to your ❤️ and give what you can—no gift is too small ➡️ go.umd.edu/givetocmns

Resultaat bekend van onderzoek naar overhevelen taak @nvwa.bsky.social naar @vngemeenten.bsky.social , wat betreft vangst en bestrijding exotische muggen zoals #tijgermug #dengue #chikungunya #zika
vng.nl/kennisbank-i...

Chikungunya: schon über 400 lokale Ansteckungen rund um die Schweiz Die Tigermücke ist weiter auf dem Vormarsch. Experten warnen vor einer wachsenden Infektionsgefahr – auch hierzulande.

Nur eine Frage der Zeit bis auch in der Schweiz lokale Übertragungen.
#Chikungunya #Dengue #Zika

www.srf.ch/wissen/gesun...

Excruciating tropical disease can now be transmitted in most of Europe, study finds ‘Shocking’ data shows the climate crisis and invasive mosquitos mean chikungunya could spread in 29 countries

If it's there it won't be long before it's here. It's just a matter of hitching a ride on an international flight.
#Chikungunya #Dengue #Zika #TropicalDisease

Amplo estudo sobre os impactos da zika Um grupo de pesquisadores brasileiros caracterizou a frequência e a gravidade das manifestações associadas à síndrome congênita do zika (SCZ), com base em informações sobre 843 crianças. “Até o moment...

A maioria dos bebês afetados pelo zika desenvolve microcefalia e alterações graves no cérebro bit.ly/4kwQgLA

#imunologia #saúdepública #microcefalia #zika

📢 European Commission @ec.europa.eu @euclimateaction.bsky.social: " #Paris, #Vienna, #Zagreb and other European cities will be at more risk of #dengue, #Zika and #chikungunya #outbreaks as #ClimateChange expands #mosquito range 🦟"
environment.ec.europa.eu/news/paris-v...

#Wilderei #Epidemie #Pandemie #Fleisch #Gesundheit #Umwelt #Natur #Schuppentier #Kultur #gefährdeteArten #Umweltschutz #Tierschutz #Naturschutz #Ebola #Zika #Hühnergrippe #Schweinegrippe #Borreliose #Affenpocken #Fleischverzehr #WetMarkets #Wildtier #GoVegan #epidemie #Virusinfektion #teamVorsicht
_

🦟 10 years ago, WHO declared Zika a global health emergency. Thousands of babies in Brazil were born with microcephaly.
A decade later: are we truly better prepared—or just better at renaming cars? 💔 #Zika #PublicHealth

A new study suggests #habitatloss is driving #mosquitoes in Brazil’s Atlantic Forest to feed more on humans, raising concerns about #vectorborne #diseases like #dengue, #Zika, and #yellowfever.

scitechdaily.com/scientists-w...

📢 @who.int EPI-WIN #webinar:
#Zika: ten years after the public health emergency 🦟

Date: 2 February 2026 13:00 – 14:30 CET (Virtual meeting)

www.who.int/news-room/ev...

Reisen und Mücken: So schützen Sie sich vor Krankheiten Bei Reisen vor allem in tropische und subtropische Regionen besteht die Gefahr, sich mit mückenübertragenen Krankheiten wie Chikungunya, Dengue, Zika und Malaria zu infizieren. Daher ist es wichtig, s...

"(...)Die Asiatische Tigermücke, die sich auch in der Schweiz gerade ausbreitet, kann etwa 20 verschiedene Krankheitserreger weitergeben. "
#Dengue
#Malaria
#Zika
#Chikungunya
#Yelllowfever
#WestNilefever

www.bag.admin.ch/de/reisen-un...

Lixo acumulado e chuva multiplicam risco de dengue e outras doenças em BH Infectologista cita possibilidade de aumento dos focos do Aedes, cita risco da leptospirose e de acidentes com escorpião

Infectologista cita possibilidade de aumento dos focos do Aedes, cita risco da leptospirose e de acidentes com escorpião

#saúdeebemestar #greve #garis #lixoacumulado #slu #chuvas #risco #aedesaegypti #dengue #chikungunya #zika #saúdepública #jornalhojeemdia

#Zika was first identified in Uganda in 1947 in monkeys and was later identified in humans in 1952. The 2015 Zika epidemic was a reminder of how quickly flaviviruses can become significant public health threats.

How well do you know flaviviruses? #MappingTheRisk
flavivaccine.eu/flavivirus/

Original post on mastodon.online

#Steady-#Klimacrew

Ein Forscherteam hat mithilfe von Künstlicher Intelligenz die #Proteinstrukturen der #Flaviviridae-#Virenfamilie untersucht, zu der u.a. #HepatitisC, #Zika und #Dengue gehören.

Dabei haben sie Entdeckungen gemacht, die die Entwicklung von #Impfstoffe​n erleichtern könnten […]

¿Por qué los mosquitos nos pican más? Cae la biodiversidad La pérdida de biodiversidad cambia el comportamiento de los mosquitos y aumenta su contacto con humanos, elevando el riesgo de transmisión de virus. La idea suena casi a chiste malo hasta que la pones...

¿Por qué los mosquitos nos pican más? Cae la biodiversidad #mosquitos #biodiversidad #saludpublica #dengue #zika #chikunguña #medioambiente #ciencia #deforestacion #riesgosanitario #ecologia #15deenero #felizjueves donporque.com/los-mosquito...

DOH IDENTIFIES SEPARATE TRAVEL-RELATED CASES OF ZIKA AND DENGUE VIRUS ON OʻAHU HONOLULU — The Hawai‘i Department of Health (DOH) has identified a travel-related case of Zika virus and a separate travel-related case of dengue virus. Although both are on Oʻahu, these are unrelated...

The #Hawai‘i Department of Health (DOH) has identified a #travel-related case of #Zika virus and a separate travel-related case of #dengue virus. Although both are on Oʻahu, these are unrelated cases. More: health.hawaii.gov/news/newsroo...