Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...

#WeekendRead! #DendriticCellPower! @reisesousalab.bsky.social @drjonlim.bsky.social &co show @natimmunol.nature.com that cDC1s exploit DNGR1 to crosspresent #tumor #neoantigens derived from F-actin binding proteins protecting against tumorigenesis but favoring cancer immunoediting!

STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity - Nature Immune checkpoint blockade activates T cell immunity by reprogramming the STAT3 and STAT5 transcriptional pathways in dendritic cells, and STAT3 degradation is effective for treating tumours...

#WeekendRead! #DendriticCellPower #FirstLove! Wang Zou &co show @nature.com that #NotAllSTATsAreEqual & STAT3 restrains anti-tumor DC functions driven by STAT5. STAT3 degraders protect against advanced, metastatic, & immunecheckpoint blockade-resistant cancers! www.nature.com/articles/s41...

Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens Deleting a regulatory element in the Rorc gene depletes RORγt+ dendritic cells from the intestine in mice, leading to a reduction of regulatory T cells and impaired oral tolerance to antigens. This wo...

#FirstLove #DendriticCellPower! Fernandes Rodrigues, Wu, Colonna &co show @CellCellPress that Rorgt DCs, not ILC3s, are fundamental to maintain gut Tregs, preventing Th2 cell expansion & #food #allergy! www.cell.com/cell/fulltex...