STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity - Nature Immune checkpoint blockade activates T cell immunity by reprogramming the STAT3 and STAT5 transcriptional pathways in dendritic cells, and STAT3 degradation is effective for treating tumours...

#WeekendRead! #DendriticCellPower #FirstLove! Wang Zou &co show @nature.com that #NotAllSTATsAreEqual & STAT3 restrains anti-tumor DC functions driven by STAT5. STAT3 degraders protect against advanced, metastatic, & immunecheckpoint blockade-resistant cancers! www.nature.com/articles/s41...