New insights into how the immunological synapse organizes signaling, controls immune activation, and shapes therapeutic strategies across disease contexts.
#ImmunologicalSynapse #TCells #ImmuneSignaling #MolecularMechanisms #Immunotherapy
www.nature.com/articles/s41...

This review summarizes recent advances in the #ImmunologicalSynapse, detailing its structure, #SignalingPathways and highlights how its dysregulation drives disease while revealing #TherapeuticTargets for immune modulation. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Xing et al develop a way to combine oncolytic virus & CAR-T therapy by specifically loading VSV onto the surface of CAR-T cells. This can directly pre-activate CAR-T cells via cross-connection btwn viral particles & CAR moieties & induce #ImmunologicalSynapse formation rupress.org/jem/article/...

Xing et al develop a way to combine oncolytic virus & CAR-T therapy by specifically loading VSV onto the surface of CAR-T cells. This can directly pre-activate CAR-T cells via cross-connection btwn viral particles & CAR moieties & induce #ImmunologicalSynapse formation rupress.org/jem/article/...

ALK2/3 recruitment to the #ImmunologicalSynapse is required for T cell activation and death, say Jun-Ge Shi, Hong-Bing Shu, Shu Li et al.
rupress.org/jem/article/...

#LymphocyteBiology