Kaplan-Meier curves illustrate RBM20 truncating variant penetrance. Graphs A & B show survival free from Arrhythmogenic DCM & AF diagnosis for RBM20sv, RBM20tv, and TTNtv variants. C & D show survival free from MHFVA & MHF composite for P/LP, Truncating, and VUS variants.

RBM20 truncating variants were associated with reduced lifetime penetrance and milder disease in #DilatedCardiomyopathy compared to pathogenic RBM20 or titin variants, suggesting a low-effect role in arrhythmogenic cardiomyopathy. ja.ma/4ttY8ki

Qiliqiangxin Alleviates Imbalance of Inflammatory Cytokines in Patients with Dilated Cardiomyopathy: A Randomized Controlled Trial

This study demonstrates that #Qiliqiangxin may rebalance #Inflammatory #Cytokines in patients with #DilatedCardiomyopathy, and that combining it with standard anti-#HeartFailure medications could further improve #CardiacFunction. #medsky

To read: doi.org/10.1007/s115...

Partial restoration of mitochondrial dysfunction by AAV-Ant1 protects from dilated cardiomyopathy in Ant1-/- plus mtDNA mutant mice - Nature Communications Patients with primary mitochondrial disease manifesting cardiomyopathy are twice as likely to die compared to those without cardiomyopathy. Here, the authors show that a modest increase in cardiac mit...

#TargetedGeneTherapy for partial restoration of #MitochondrialFunction and protection against #DilatedCardiomyopathy www.nature.com/articles/s41... #MitochondrialCardiomyopathy #CardiacFunction #PGC1α #TranslationalScience

A patient-specific engineered tissue model of BAG3-mediated cardiomyopathy
Journal of Tissue Engineering
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#cardiactissueengineering #dilatedcardiomyopathy #iPSCmodels #precisioncardiology #openaccess

Divergent TPM1 mutants in #HypertrophicCardiomyopathy (E62Q) vs #DilatedCardiomyopathy (E54K)

#hiPSC #Cardiomyocyte
Engineered heart tissue
Twitch kinetics
Diastolic stiffness
RNAseq/Proteomics

E62Q⬇️effective stiffness
E54K⬆️Tropomyosin–troponin I interaction

#JCI 2024
www.jci.org/articles/vie...

Biventricular Thrombi in a Patient With Dilated Cardiomyopathy In patients with dilated cardiomyopathy, it is important to thoroughly examine the right ventricle for the presence of a thrombus during transthoracic echocardiography, in addition to the left ventri....

Biventricular thrombi can complicate #DilatedCardiomyopathy. Careful #RightVentricular assessment on #echocardiography is essential when #LeftVentricular #thrombus is detected. onlinelibrary.wiley.com/doi/10.1002/...

Sex-specific genetic differences identified in dilated cardiomyopathy | Imperial News | Imperial College London Researchers from Imperial have uncovered key genetic differences in how dilated cardiomyopathy (DCM) affects men and women.

Research from @imperialnhli.bsky.social has uncovered key genetic differences in how #DilatedCardiomyopathy (DCM) affects men and women.

The study, led by Dr Upasana Tayal, helps explain why men are twice as likely to develop DCM, even in genetic forms.👇
www.imperial.ac.uk/news/266793/...

Comparing fully automated 3DE quantification and cardiac magnetic resonance imaging for left ventricular volume and function evaluation in patients with dilated cardiomyopathy AbstractBackground. Integration of artificial intelligence enhances precision, yielding dependable evaluations of left ventricular volumes and ejection fra

AI-powered fully automated #3DEchocardiography shows strong correlation with cardiac #MRI for left ventricular volumes in dilated cardiomyopathy, offering a fast, reliable alternative. Contour editing may improve accuracy in some cases. #CMR #DilatedCardiomyopathy academic.oup.com/ehjcimaging/...

Chest xray of a dog that has dilated cardiomyopathy

This is an x-ray of the heart/chest of a canine with DCM (Dilated Cardiomyopathy) that is showing NO symptoms but needs treatment based on echocardiogram (heart ultrasound). #notaboutthemoney #dcm #dilatedcardiomyopathy #aryaanimalacupuncture #dogmom #dogs #cvt #vetmed #vettech #veterinarian

2X #DilatedCardiomyopathy GWAS MATG #NatGenet 2024 reveal novel genes/cellular players

PROX1 - #LymphaticEndothelialCell
ERG - #EndothelialCell
DGKG - #SmoothMuscleCell
MAPT/Tau validated in both studies

>9k case
www.nature.com/articles/s41...

>14k case
www.nature.com/articles/s41...

Myocardial Tauopathy in #AlzheimersDisease or idiopathic #DilatedCardiomyopathy

HMw (100~110, not 55 kD) Tau in🫀

In iDCM🫀
⏫pSer396/404 (not total) Tau
⏫Toxic Tau oligomer

3-to 12-mo hTau🐭➡️#DiastolicDysfunction

Relationship with #CadiacAmyloidosis?😁
#EHJ 2023
academic.oup.com/eurheartj/ar...

Case 131: When the Dilatation is Mechanical
44-years old with dilated cardiomyopathy
www.mricardiac.com/case131/
#cmrsimplified #cmr #cardiacmri #aorticregurgitation #dilatedcardiomyopathy #DCM