#TFE3 overexpression protects against #Parkinsons by enhancing #αsynuclein degradation, inhibiting its propagation, restoring #autophagy and #MitochondrialBiogenesis, and improving motor function—highlighting TFE3 as a therapeutic target.

#OpenAccess: doi.org/10.1016/j.ge...

This study shows that #TFE3 regulates #Mitochondrial metabolism in #DopaminergicNeurons by up-regulating Parkin to promote #Autophagy & elevating #PGC1α and TFAM to enhance mitochondrial biogenesis in #ParkinsonsDisease. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Congrats to Gurpreet Kaur, on a successful MSc. defence. Incredibly proud of Gurpreet for a thesis well done, examining the role of #TFE3 in #cardiomyocyte #metabolism and function. Thanks to the examining and supervisory research committee for their feedback @dalhousieu.bsky.social