#TFE3 overexpression protects against #Parkinsons by enhancing #αsynuclein degradation, inhibiting its propagation, restoring #autophagy and #MitochondrialBiogenesis, and improving motor function—highlighting TFE3 as a therapeutic target.

#OpenAccess: doi.org/10.1016/j.ge...

Online now - the Spotlight "Balancing act: lipid-to-protein ratios steer the aggregation fate of #αsynuclein" from Christian Blum and Mireille Claessens.

#LipidMembranes #ProteinAggregation #Amyloid

authors.elsevier.com/a/1kgCK3S6Gf...

🧠 #rPeptide Preformed fibrils' (PFFs') effectively seed the aggregation of endogenous proteins within cells, simulating the spread and progression of #neurodegenerative diseases like #Parkinson's or #Alzheimer's diseases
🔗https://tinyurl.com/32vx9vm9
#αsynuclein #Amyloid #Tau441