#TFE3 overexpression protects against #Parkinsons by enhancing #αsynuclein degradation, inhibiting its propagation, restoring #autophagy and #MitochondrialBiogenesis, and improving motor function—highlighting TFE3 as a therapeutic target.

#OpenAccess: doi.org/10.1016/j.ge...

Harnessing mitochondrial biogenesis to combat acute kidney injury: Current insights and future directions

This review analyzes and describes the general processes and regulatory mechanisms of #MitochondrialBiogenesis (MB) and its association with #AcuteKidneyInjury (AKI) and discusses compounds targeting MB, highlighting its potential to treat AKI. #medsky

#OpenAccess: buff.ly/Ngc5O95

🫵In case you missed our webinar

🗣️Mitochondrial biogenesis: dive into the beating heart of the eukaryotic cell

🎦You can now watch it on-demand
🖥️https://buff.ly/cwiIPCw

#Mitochondria #MitochondrialBiogenesis #MembraneProteins @Herrmann_lab

TFE3-mediated neuroprotection: Clearance of aggregated α-synuclein and accumulated mitochondria in the AAV-α-synuclein model of Parkinson's disease

TFE3 alleviates loss of dopaminergic neurons, promotes #autophagy of accumulated α-Syn and mitochondria, and enhances #MitochondrialBiogenesis in an AAV-α-Syn model, thus highlighting its role as a potential therapeutic target for #ParkinsonsDisease. #medsky

#OpenAccess: www.sciencedirect.co...